(a.) To lower or depress; to throw or cast down; as, to abase the eye.
(a.) To cast down or reduce low or lower, as in rank, office, condition in life, or estimation of worthiness; to depress; to humble; to degrade.
Example Sentences:
(1) And then, proving that in the celebrity world of self-abasement there really is no such thing as "bottoming out", Shane started tweeting Ping Pong, otherwise known as Elizabeth Hurley's parrot Why has Australia not staged an intervention?
(2) These studies establish that the exocyclic ring of the 1,N2-propanodeoxyguanosine adduct fits into the cavity generated by the abasic site.
(3) Covalently closed circular DNA containing a synthetic analog of an abasic site at a unique position was used as a substrate to study DNA repair.
(4) In this study, we present structural and dynamic properties of duplex oligodeoxynucleotides containing G, C and T opposite a model abasic site studied by one and two-dimensional nuclear magnetic resonance spectroscopy.
(5) By this assay, we first identified the formation of C-4'-hydroxy abasic sites in calf thymus DNA by neocarzinostatin.
(6) Abasic lesions in the template had relatively little effect on the polymerase incorporation reaction at sites proximal to the lesion.
(7) Facebook Twitter Pinterest A composite handout of CCTV pictures from the Metropolitan police showing British teenagers (L-R) Kadiza Sultana, Amira Abase and Shamima Begum passing through security barriers at Gatwick Airport en route to Syria.
(8) Proton and phosphorus NMR studies are reported for two complementary nonanucleotide duplexes containing acyclic abasic sites.
(9) Shamima Begum, 15, Amira Abase, 15, and Kadiza Sultana, 16, left their homes in east London last month to join the extremist group.
(10) However, incorporation opposite an abasic site was undetectable relative to that which occurred opposite a normal template nucleotide.
(11) But with the People's Daily writing that progress had only been possible because of David Cameron's admission that he had mishandled Tibet (where, since 2009, 100 monks and nuns have set fire to themselves in protest against Chinese rule), Britain's abasement was complete.
(12) Shamima Begum, 15, Kadiza Sultana, 16, and Amira Abase, 15, fled in February from Britain after deceiving their parents and siblings.
(13) The long pilgrimage of pregnancy with its wonders and abasements, the apotheosis of childbirth, the sacking and slow rebuilding of every last corner of my private world that motherhood has entailed – all unmentioned, wilfully or casually forgotten as time has passed.
(14) Before and after training they were low in need for order, endurance, abasement, and deference and high in need for autonomy and aggression.
(15) All the sequenced mutants correspond to single base-pair substitutions targeted at the abasic site.
(16) These results indicate that dTMP, and not dAMP, was mainly incorporated into the sites opposite to the abasic site analogue, and that incorrect deoxynucleotides were incorporated in the position adjacent to the abasic site analogue.
(17) Our results in human cells contrast markedly with those published previously for the mutational specificity of AP sites in Escherichia coli, in which a large majority of the mutants resulted from insertion of an A opposite the abasic site.
(18) The repair-related DNA synthesis was localized within 3 or 4 nucleotides surrounding the abasic site.
(19) The enzyme is able to incorporate nucleotides efficiently opposite the abasic template lesion and to continue DNA synthesis.
(20) The Met statement did appear to show some contrition stating: “With the benefit of hindsight, we acknowledge that the letters could have been delivered direct to the parents.” The disappearance of the 15-year-old girl in December led to a counter-terrorism investigation that saw Begum, Sultana and Abase identified as friends of the missing girl and being spoken to by detectives.
Lower
Definition:
(a.) Compar. of Low, a.
(a.) To let descend by its own weight, as something suspended; to let down; as, to lower a bucket into a well; to lower a sail or a boat; sometimes, to pull down; as, to lower a flag.
(a.) To reduce the height of; as, to lower a fence or wall; to lower a chimney or turret.
(a.) To depress as to direction; as, to lower the aim of a gun; to make less elevated as to object; as, to lower one's ambition, aspirations, or hopes.
(a.) To reduce the degree, intensity, strength, etc., of; as, to lower the temperature of anything; to lower one's vitality; to lower distilled liquors.
(a.) To bring down; to humble; as, to lower one's pride.
(a.) To reduce in value, amount, etc. ; as, to lower the price of goods, the rate of interest, etc.
(v. i.) To fall; to sink; to grow less; to diminish; to decrease; as, the river lowered as rapidly as it rose.
(v. i.) To be dark, gloomy, and threatening, as clouds; to be covered with dark and threatening clouds, as the sky; to show threatening signs of approach, as a tempest.
(v. i.) To frown; to look sullen.
(n.) Cloudiness; gloominess.
(n.) A frowning; sullenness.
Example Sentences:
(1) These factors might account for the lower systemic bioavailability of these compounds.
(2) Patients with papillary carcinoma with a good cell-mediated immune response occurred with much lower infiltration of the tumor boundary with lymphocyte whereas the follicular carcinoma less cell-mediated immunity was associated with dense lymphocytic infiltration, suggesting the biological relevance of lymphocytic infiltration may be different for the two histologic variants.
(3) In this study of ten consecutive patients sustaining molten metal injuries to the lower extremity who were treated with excision and grafting, treatment with compression Unna paste boot was compared with that with conventional dressing.
(4) Propranolol resulted in a significantly lower mean hourly, mean 24 h and minimum heart rate.
(5) Homozygotes have sparse greasy fur and lower viability and fertility than normal littermates.
(6) LHRH therapy leads to higher plasma LH levels and a lower FSH in response to an intravenous LHRH test.
(7) On the other hand, the LAP level, identical in preterms and SDB, is lower than in full-term infants but higher than in adults.
(8) It is suggested that the Japanese may have lower trabecular bone mineral density than Caucasians but may also have a lower threshold for fracture of the vertebrae.
(9) Spontaneous locomotor activity was lower in naloxone-infused rats on day 3 only.
(10) After 55 days of unrestricted food availability the body weight of the neonatally deprived rats was approximately 15% lower than that of the controls.
(11) There is no evidence that health-maintenance organizations reduce admissions in discretionary or "unnecessary" categories; instead, the data suggest lower admission rates across the board.
(12) The rate of accumulation of degraded LDL products was lower in collagen gel cultures, but the final levels achieved were the same in the two substrata.
(13) [Ca2+]i exhibited a sigmoidal dependence on [Na+]o. Mg2+, a competitive inhibitor of Na2+-Ca2+ antiport in these cells, antagonized the increase in [Ca2+]i produced by lowering [Na+]o.
(14) Side effect incidence in patients treated with the paracetamol-sobrerol combination (3.7%) was significantly lower than that observed in subjects treated with paracetamol (6.1% - P less than 0.01), salicylics (25.1% - P less than 0.001), pyrazolics (12.6% - P less than 0.001), propionics (20.3%, P less than 0.001) or other antipyretics (17.9% - P less than 0.001).
(15) These findings suggest that clonidine transdermal disks lower blood pressure in hypertensive patients, but produce local skin lesions and general side effects.
(16) Diltiazem monotherapy effectively lowered blood pressure in 60% of patients at 8 weeks.
(17) Thus, our study confirmed that male subjects with a history of testicular maldescent have an increased risk for testis cancer, although the magnitude of this risk was lower than suggested previously.
(18) Anesthetized sheep (n = 6) previously prepared with a lung lymph fistula underwent 2 hr of tourniquet ischemia of both lower limbs.
(19) Nicardipine lowered systolic and diastolic blood pressure to normal, plasma aldosterone was reduced and serum potassium levels were increased.
(20) The overall recoveries of activated ER following chromatography on DEAE-cellulose were significantly lower than the recoveries of the nonactivated ER, 71 and 85%, respectively.