(n.) The act of abasing, humbling, or bringing low; the state of being abased or humbled; humiliation.
Example Sentences:
(1) And then, proving that in the celebrity world of self-abasement there really is no such thing as "bottoming out", Shane started tweeting Ping Pong, otherwise known as Elizabeth Hurley's parrot Why has Australia not staged an intervention?
(2) These studies establish that the exocyclic ring of the 1,N2-propanodeoxyguanosine adduct fits into the cavity generated by the abasic site.
(3) Covalently closed circular DNA containing a synthetic analog of an abasic site at a unique position was used as a substrate to study DNA repair.
(4) In this study, we present structural and dynamic properties of duplex oligodeoxynucleotides containing G, C and T opposite a model abasic site studied by one and two-dimensional nuclear magnetic resonance spectroscopy.
(5) By this assay, we first identified the formation of C-4'-hydroxy abasic sites in calf thymus DNA by neocarzinostatin.
(6) Abasic lesions in the template had relatively little effect on the polymerase incorporation reaction at sites proximal to the lesion.
(7) Facebook Twitter Pinterest A composite handout of CCTV pictures from the Metropolitan police showing British teenagers (L-R) Kadiza Sultana, Amira Abase and Shamima Begum passing through security barriers at Gatwick Airport en route to Syria.
(8) Proton and phosphorus NMR studies are reported for two complementary nonanucleotide duplexes containing acyclic abasic sites.
(9) Shamima Begum, 15, Amira Abase, 15, and Kadiza Sultana, 16, left their homes in east London last month to join the extremist group.
(10) However, incorporation opposite an abasic site was undetectable relative to that which occurred opposite a normal template nucleotide.
(11) But with the People's Daily writing that progress had only been possible because of David Cameron's admission that he had mishandled Tibet (where, since 2009, 100 monks and nuns have set fire to themselves in protest against Chinese rule), Britain's abasement was complete.
(12) Shamima Begum, 15, Kadiza Sultana, 16, and Amira Abase, 15, fled in February from Britain after deceiving their parents and siblings.
(13) The long pilgrimage of pregnancy with its wonders and abasements, the apotheosis of childbirth, the sacking and slow rebuilding of every last corner of my private world that motherhood has entailed – all unmentioned, wilfully or casually forgotten as time has passed.
(14) Before and after training they were low in need for order, endurance, abasement, and deference and high in need for autonomy and aggression.
(15) All the sequenced mutants correspond to single base-pair substitutions targeted at the abasic site.
(16) These results indicate that dTMP, and not dAMP, was mainly incorporated into the sites opposite to the abasic site analogue, and that incorrect deoxynucleotides were incorporated in the position adjacent to the abasic site analogue.
(17) Our results in human cells contrast markedly with those published previously for the mutational specificity of AP sites in Escherichia coli, in which a large majority of the mutants resulted from insertion of an A opposite the abasic site.
(18) The repair-related DNA synthesis was localized within 3 or 4 nucleotides surrounding the abasic site.
(19) The enzyme is able to incorporate nucleotides efficiently opposite the abasic template lesion and to continue DNA synthesis.
(20) The Met statement did appear to show some contrition stating: “With the benefit of hindsight, we acknowledge that the letters could have been delivered direct to the parents.” The disappearance of the 15-year-old girl in December led to a counter-terrorism investigation that saw Begum, Sultana and Abase identified as friends of the missing girl and being spoken to by detectives.
Basement
Definition:
(a.) The outer wall of the ground story of a building, or of a part of that story, when treated as a distinct substructure. ( See Base, n., 3 (a).) Hence: The rooms of a ground floor, collectively.
Example Sentences:
(1) Administration of aminonucleoside and daunomycin produced proteinuria but did not cause a decrease in lipid P. Anticollagen and anti-lymphocyte sera that attached to the basement membrane but failed to produce proteinuria, also failed to affect the phospholipid content.
(2) The present results suggest that in addition to sulfated glycosaminoglycan some nonsulfated glycosaminoglycan (hyaluronic acid) may also be present in the glomerular basement membrane.
(3) They had no endocrine-like granules and were not associated with nerves or basement membranes.
(4) However, when beta-xyloside-treated cultures were supplied with exogenous basement membrane, Schwann cells produced numerous myelin segments.
(5) The diffuse reaction product seen in basement membranes of ganglion and nerve may also be artifact.
(6) As an extension of the previous study which indicated that mesoglea is a primitive basement membrane which has retained some characteristics of interstitial extracellular matrix, the present study was undertaken to analyze the role of mesoglea components during head regeneration in Hydra vulgaris.
(7) Electron microscopic examination of all leptomeningeal and meningioma cultures revealed desmosomes and dense tonofilament formation; in addition, granular, filamentous basement membrane-like material was abundant in the extracellular spaces of all cultures.
(8) LV force production is dependent on the coupling of myocytes to the extracellular matrix, which is mediated through the basement membrane.
(9) The authors conclude that certain basement membrane components actively promote fetal intestinal epithelial cell differentiation.
(10) Laminin is a constituent of the basement membrane in both chicken and quail blastoderms.
(11) That these antilaminin antibodies were, at least in part, responsible for the toxicity was indicated 1) by reduced cultured embryo toxicity for six of seven serum samples after pre-absorption with purified laminin, 2) by demonstrating a relationship between the amount of affinity-purified antilaminin IgG added to control serum for culture and the severity of embryo abnormalities seen at the end of culture, and 3) by the sera's failing to react with other basement membrane proteins, including type IV collagen, fibronectin, osteonectin, and heparan sulfate proteoglycan.
(12) To study the role of the serum complement system in the early necrosis of acinar cells an acute pancreatitis was produced by injection of basement membrane antibodies into the pancreatic duct of mice and rats.
(13) This enhancement of laminin synthesis corresponds to the mesangial expansion and to the development of laminin-containing spike formations of the glomerular basement membrane at week 8.
(14) In autumn, leaf-heaps composted themselves on sunken patios, and were shovelled up by irritated owners of basement flats.
(15) Pathological consequences of these events include inflammatory neutrophil infiltration, damage to the collagen and mucosal basement membrane, increased capillary permeability, edema, cell degeneration and necrosis.
(16) Ultrastructural examination of a tumor with a typical cribriform pattern showed spaces of two types; the more frequent type was bounded by cells with straight plasma membranes and contained filamentous and basement-membrane-like material, and the less frequent type was surrounded by cells with numerous microvilli and contained nonfilamentous homogeneous material.
(17) Laminin, a major component of basement membranes, is known to be present in the internal limiting membrane, and might be involved in the growth of ganglion cell axons.
(18) A case of bullous disease in a child with linear IgA immune deposits at the basement membrane zone and with some clinical, histological, and electron microscopic characteristics both of dermatitis herpetiformis and bullous pemphigoid, is described.
(19) This agrees with previous ultrastructural observations that, in small mammals, neither basement membranes nor large connective tissue spaces are found inside enteric ganglia.
(20) We tested for the distribution of basement membrane (BM) components collagen IV, laminin, heparan sulphate proteoglycan, fibronectin, for S100 protein and for the presence of interstitial collagens III and V. Laminin was generally noted in association with Schwann cells, but collagen IV occurred with perineural cells.