(n.) The act of abasing, humbling, or bringing low; the state of being abased or humbled; humiliation.
Example Sentences:
(1) And then, proving that in the celebrity world of self-abasement there really is no such thing as "bottoming out", Shane started tweeting Ping Pong, otherwise known as Elizabeth Hurley's parrot Why has Australia not staged an intervention?
(2) These studies establish that the exocyclic ring of the 1,N2-propanodeoxyguanosine adduct fits into the cavity generated by the abasic site.
(3) Covalently closed circular DNA containing a synthetic analog of an abasic site at a unique position was used as a substrate to study DNA repair.
(4) In this study, we present structural and dynamic properties of duplex oligodeoxynucleotides containing G, C and T opposite a model abasic site studied by one and two-dimensional nuclear magnetic resonance spectroscopy.
(5) By this assay, we first identified the formation of C-4'-hydroxy abasic sites in calf thymus DNA by neocarzinostatin.
(6) Abasic lesions in the template had relatively little effect on the polymerase incorporation reaction at sites proximal to the lesion.
(7) Facebook Twitter Pinterest A composite handout of CCTV pictures from the Metropolitan police showing British teenagers (L-R) Kadiza Sultana, Amira Abase and Shamima Begum passing through security barriers at Gatwick Airport en route to Syria.
(8) Proton and phosphorus NMR studies are reported for two complementary nonanucleotide duplexes containing acyclic abasic sites.
(9) Shamima Begum, 15, Amira Abase, 15, and Kadiza Sultana, 16, left their homes in east London last month to join the extremist group.
(10) However, incorporation opposite an abasic site was undetectable relative to that which occurred opposite a normal template nucleotide.
(11) But with the People's Daily writing that progress had only been possible because of David Cameron's admission that he had mishandled Tibet (where, since 2009, 100 monks and nuns have set fire to themselves in protest against Chinese rule), Britain's abasement was complete.
(12) Shamima Begum, 15, Kadiza Sultana, 16, and Amira Abase, 15, fled in February from Britain after deceiving their parents and siblings.
(13) The long pilgrimage of pregnancy with its wonders and abasements, the apotheosis of childbirth, the sacking and slow rebuilding of every last corner of my private world that motherhood has entailed – all unmentioned, wilfully or casually forgotten as time has passed.
(14) Before and after training they were low in need for order, endurance, abasement, and deference and high in need for autonomy and aggression.
(15) All the sequenced mutants correspond to single base-pair substitutions targeted at the abasic site.
(16) These results indicate that dTMP, and not dAMP, was mainly incorporated into the sites opposite to the abasic site analogue, and that incorrect deoxynucleotides were incorporated in the position adjacent to the abasic site analogue.
(17) Our results in human cells contrast markedly with those published previously for the mutational specificity of AP sites in Escherichia coli, in which a large majority of the mutants resulted from insertion of an A opposite the abasic site.
(18) The repair-related DNA synthesis was localized within 3 or 4 nucleotides surrounding the abasic site.
(19) The enzyme is able to incorporate nucleotides efficiently opposite the abasic template lesion and to continue DNA synthesis.
(20) The Met statement did appear to show some contrition stating: “With the benefit of hindsight, we acknowledge that the letters could have been delivered direct to the parents.” The disappearance of the 15-year-old girl in December led to a counter-terrorism investigation that saw Begum, Sultana and Abase identified as friends of the missing girl and being spoken to by detectives.
Degradation
Definition:
(n.) The act of reducing in rank, character, or reputation, or of abasing; a lowering from one's standing or rank in office or society; diminution; as, the degradation of a peer, a knight, a general, or a bishop.
(n.) The state of being reduced in rank, character, or reputation; baseness; moral, physical, or intellectual degeneracy; disgrace; abasement; debasement.
(n.) Diminution or reduction of strength, efficacy, or value; degeneration; deterioration.
(n.) A gradual wearing down or wasting, as of rocks and banks, by the action of water, frost etc.
(n.) The state or condition of a species or group which exhibits degraded forms; degeneration.
(n.) Arrest of development, or degeneration of any organ, or of the body as a whole.
Example Sentences:
(1) This bone could not be degraded by human monocytes in vitro as well as control bone (only 54% of control; P less than 0.003).
(2) Lp(a) also complexes to plasmin-fibrinogen digests, and binding increases in proportion to the time of plasmin-induced fibrinogen degradation.
(3) The rate of accumulation of degraded LDL products was lower in collagen gel cultures, but the final levels achieved were the same in the two substrata.
(4) At the highest dose of chloroquine tested (500 microM), a slightly greater increase in insulin binding and a decrease in insulin degradation were observed in fetal cells as compared with adult cells.
(5) Addition of extracellular mevalonate led to a concentration-dependent fall in both processes, although a higher concentration was required to produce the same effect on LDL degradation as on HMG-CoA reductase activity.
(6) Radioiodinated a-factor was used to identify the a-factor-degrading activity, which is cell associated, endoproteolytic, and not required for response to pheromone.
(7) Densitometric analysis of myofibrillar proteins separated with sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that troponin I and troponin T were degraded during 60 minutes of CGI.
(8) In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant.
(9) Degradation of both viral and host DNA with micrococcal nuclease and spleen phosphodiesterase indicated that CdG was incorporated primarily into internal positions in both DNAs.
(10) In vitro studies showed that BOF-A2 was rapidly degraded to EM-FU and CNDP in homogenates of the liver and small intestine of mice and rats, and in sera of mice, rats and human, and the conversion of EM-FU to 5-FU occurred only in the microsomal fraction of rat liver in the presence of NADPH.
(11) Only PPACK completely inhibited changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin.
(12) On the other hand, if we correct for the population of HMM with degraded light chain 2, the difference in the binding constants in the presence and absence of Ca2+ may be as great as 5-fold.
(13) When cultures were pulse labeled for 15 min and then incubated under chase conditions for 105 min, the amount of degraded collagen attained a value equal to approximately 20% of the amount synthesized during the labeling period; the data were fit with a simple exponential function that had a 40-min rise time and a 12-min lag time.
(14) The mode of ribosome degradation under this condition is discussed in terms of differential appearance of these intermediate particles.
(15) Degraded visual acuity had a significant effect on cadence, foot placement, and foot clearance, but visual surround conditions did not.
(16) The resistance of GSA 65 to proteolytic degradation, together with previous immunofluorescence data that indicate the antigen is an integral part of the G. lamblia cyst wall, suggests that this molecule may play a role in maintaining the integrity of the cyst in vivo.
(17) 5% of the degradation resulted from enzymatic activity in the culture medium, presumably due to secretion of proteolytic enzymes by the cells.
(18) At 37 degrees C, 125I-labeled TNF-alpha was rapidly internalized and degraded in L-929, U-937 and LAK cells.
(19) Recovery after EEDQ administration showed that both receptor production rate and degradation rate constants of anterior pituitary D2 and striatal D1 receptors were slowed after chronic estradiol treatment, whereas recovery rates for striatal D2 dopamine receptors were unaffected.
(20) The specific rates of degradation of L-arginine-AMC, gly-proline-AMC, N-alpha-benzoyl-L-arginine-AMC and N-[p-toluene-sulphonyl]gly-pro-arginine-AMC were significantly greater in that group, indicating that the composition of their gingival crevicular fluid was different from that of the gingivitis group.