What's the difference between abnormal and reeler?
Abnormal
Definition:
(a.) Not conformed to rule or system; deviating from the type; anomalous; irregular.
Example Sentences:
(1) Cancer patients showed abnormally high plasma free tryptophan levels.
(2) Among the pathological or abnormal ECGs (25.6%) prevailed the vegetative-functional heart diseases with 92%.
(3) Clonal abnormalities involving chromosomes 3 and 21 were noted in two patients.
(4) Clinical signs of disease developed as early as 15 days after transition to the experimental diets and included impaired vision, decreased response to external stimuli, and abnormal gait.
(5) Among a family of 8 children, 4 presented typical clinical and biological abnormalities related to mannosidosis.
(6) Also we found that the lipid deposition in the glomeruli of patients with Alagille syndrome is related to an abnormal lipid metabolism, which is the consequence of severe cholestasis.
(7) The secondary leukemia that occurred in these patients could be distinguished from the secondary leukemia that occurs after treatment with alkylating agents by the following: a shorter latency period; a predominance of monocytic or myelomonocytic features; and frequent cytogenetic abnormalities involving 11q23.
(8) Immediate postexercise two-dimensional echocardiography demonstrated exercise-induced changes in 8 (47%) patients (2 with normal and 6 with abnormal results from rest studies).
(9) The psychiatric experts classified 11 of the perpetrators as "normal," 3 as abnormal, and 2 as psychotic.
(10) Erythrocyte membrane choline transport is abnormally high in chronic renal failure.
(11) Although the longest period required for resolving weakness was three days, the MRI, the CT and the electroencephalogram revealed no significant abnormality.
(12) Aside from these characteristic findings of HCC, it was important to reveal the following features for the diagnosis of well differentiated type of small HCC: variable thickening or distortion of trabecular structure in association with nuclear crowding, acinar formation, selective cytoplasmic accumulation of Mallory bodies, nuclear abnormalities consisting of thickening of nucleolus, hepatic cords in close contact with bile ducts or blood vessels, and hepatocytes growing in a fibrous environment.
(13) Muscle wasting in MYD may be explained by these abnormalities as well.
(14) Associated renal and other abnormalities were common.
(15) Once the normal variations are mastered, appreciation of retinal, choroidal, optic nerve, and vitreal abnormalities is possible.
(16) Eight other children (20%) had normal or borderline elevation of CPK-MB fraction and EKG abnormalities combined with abnormal echocardiograms or radionuclide angiograms, and were considered to have sustained cardiac concussion.
(17) Several investigators have attempted to correlate chromosomal abnormalities with Cornelia de Lange Syndrome (CLS), but none of them have been conclusive.
(18) It is possible that the IgE that linked abnormally with the propofol had specific binding sites for the phenyl nucleus and the isopropyl groups, which are present in propofol and many other drugs.
(19) Of 185 with readable histology, 14.6% were clinically and histologically abnormal; 19.5% were clinically abnormal but histologically normal; and 15.7% were clinically normal and histologically abnormal.
(20) Mice also had a decreased ability to develop delayed-type hypersensitivity reactions while being given cadmium; this abnormality also returned toward normal after withdrawal of cadmium.
Reeler
Definition:
(n.) One who reels.
(n.) The grasshopper warbler; -- so called from its note.
Example Sentences:
(1) Although the reeler, an autosomal recessive mutant mouse with the abnormality of lamination in the central nervous system, died about 3 weeks of age when fed ordinary laboratory chow, this mouse could grow up normally and prolong its destined, short lifespan to 50 weeks and more when given assistance in taking paste food and water from the weaning period.
(2) The metabolism of 5-hydroxytryptamine (5-HT) in the CNS was investigated in four kinds of morphologically different ataxic mice; reeler, staggerer, weaver and Purkinje cell degeneration mutants, and in hypocerebellar mice experimentally produced by injection of cytosine arabinoside.
(4) Reeler is an autosomal recessive mutation of mice that alters neuronal migration during development, yielding a general inversion of the laminae in the neocortex.
(5) Unlike dissociated hippocampal pyramidal cells, which frequently resemble their in vivo morphology, dissociated dentate granule cells bear little resemblance to their normal in vivo counterparts, but are very similar in appearance to the ectopic granule cells seen in the reeler mouse.
(6) Although we cannot determine whether the Purkinje cell loss in reeler is a primary or secondary gene effect, the possibility that the reeler gene has its effect on migration through a primary effect on neurogenesis or cell survival should be considered.
(7) The reeler cerebellum, which possesses an abnormal cytoarchitecture with numerous ectopically located Purkinje cells, was stained histochemically for the presence of 5'-nucleotidase.
(8) The distribution of the perikarya of astrocytes and other glial cells in the molecular layer of the dentate gyrus has been studied in gold chloride-sublimate preparations of rats and of normal and reeler mice, and in plastic embedded material from young adult rats.
(9) Nevertheless, while SS fibers in the normal cortex are most dense in layers I and V-VI, the reeler cortex exhibits little laminar heterogeneity in the distribution of these fibers.
(10) These comparative observations in normal and reeler mutant mice lend support to previous suggestions that L1, together with N-CAM, may play a role in the aggregation of neuronal cell bodies after migration and in the fasciculation of developing fiber bundles.
(11) This suggests that cell differentiation and the tangenital organization of reeler neocortex are normal despite cell malposition in the mutant.
(12) The specific content of P400 protein decreases in the cerebella from homozygous nervous and Purkinje cell degeneration mutant mice, where the total number of Purkinje cells is markedly reduced, and increases in those of the reeler and weaver mice where a deficit of the granule cells exists.
(13) Bergmann fibers and the distribution of Golgi epithelial cells were significantly altered in staggerer, reeler and double mutant (affected by both staggerer and reeler conditions).
(14) On the other hand, anomalies of Purkinje cells and Bergmann fibers, which are also present both in staggerer and reeler, did not follow the same additive change.
(15) However, in the reeler dentate gyrus, most postnatal cell proliferation occurs ectopically and in the hippocampus the normal "inside-out" sequence of neurogenesis is reversed, the earliest pyramidal cells generated coming to lie superficially within the stratum pyramidale and the later formed cells being added at progressively deeper levels.
(16) We performed a descriptive analysis on the arborization of dendritic processes of large pyramidal neurons in the motor cortex (hindlimb area) of normal and reeler mice, as seen in the Golgi preparations.
(17) In reeler, by contrast, fascicles of retinotectal axons are distributed through the entire thickness of SGS as well as through SO.
(18) It is evident from both cell-and fiber-stained sections that despite the obvious defect in the positioning of the hippocampal pyramidal and dentate granule cells in the reeler mouse within the radial dimension, the hippocampal formation as a whole shows a normal and consistent progression of cytoarchitectonic fields along its transverse axis, and a normal and consistent progression of changes in the structure of the hippocampus and dentate gyrus along their longitudinal axes.
(19) The characterization and thus the cloning of the reeler gene is therefore important for our understanding of brain development.
(20) The apical dendrites of the CC neurons in all layers of the cortex of the reeler mouse are randomly oriented; no direct relationship between the intracortical position of the soma and orientation of the apical dendrite was found.