(v. t.) To annul by an authoritative act; to abolish by the authority of the maker or his successor; to repeal; -- applied to the repeal of laws, decrees, ordinances, the abolition of customs, etc.
(v. t.) To put an end to; to do away with.
Example Sentences:
(1) Although Jeggo's Chinese hamster ovary cells were more responsive to mAMSA, novo still abrogated mAMSA toxicity in the mutant cells as well as in the parental Chinese hamster ovary cells 2,4-Dinitrophenol acted similarly to novo with respect to mAMSA killing, but neither compound reduced the ATP content of V79 cells.
(2) LPS also abrogated the ability of recombinant interferon-gamma (r.IFN-gamma) to enhance macrophage larvicidal activity.
(3) Release of 51Cr was apparently a function of immune thymus-derived lymphocytes (T cells) because it was abrogated by prior incubation of spleen cells with anti-thymus antiserum and complement but was undiminished by passage of spleen cells through nylon-wool columns.
(4) In contrast, insertion of a pre-S(1) sequence between HBcAg residues 75 and 83 abrogated recognition of HBcAg by 5 of 6 anti-HBc monoclonal antibodies and diminished recognition by human polyclonal anti-HBc.
(5) Furthermore, exogenous IL-1, IL-2, IL-4, interferon-gamma, or a rat Con A supernatant failed to abrogate DFMO inhibition.
(6) A T cell was responsible for the suppressive effects on LAK generation because suppression was abrogated by treatment of alloimmune cells with anti-T serum plus complement.
(7) Inhibitors of DC clustering, including trypsin, paraformaldehyde, and tunicamycin, abrogated the ability of DC to support antigen presentation and lectin-mediated proliferation.
(8) Bound fluorescyl ligand, increased ionic strength (0.5 M NaCl) or basic pH (greater than 8.0) abrogated cryoprecipitation.
(9) One of the renal antigens recognized by 2B4.14.1 was identified as Tamm-Horsfall glycoprotein (THGP), based on the ability of the antibody to recognize THGP in western immunoblots and the abrogation of immunohistologic reactivity of the antibody by preincubation with purified THGP.
(10) Furthermore, treatment of AC with lysosomotropic agents abrogated thymocyte proliferation induced by PE but not SEB.
(11) Pretreatment with OKT3, together with a monoclonal anti-DR antibody and complement, did not abrogate the T-colony forming capacity.
(12) Resistance of the rat induced by C. liquefaciens to tumor cells was also abrogated by Trypan Blue treatment just 1 day before tumor cell inoculation.
(13) Serum SIRS-inducing activity was abrogated by treatment with proteinase K or boiling, but was not affected by dialysis, acidification to pH 2, or heating to 56 degrees C. This serum factor could be distinguished functionally and antigenically from SIRS and from interferon (IFN) alpha or IFN gamma.
(14) It is shown that while not affecting other mononuclear cells viability, this IT is capable of selectively destroying human monocytes after 24 h exposure thus resulting in the abrogation of monocyte support for PHA reactivity in mononuclear cell preparations.
(15) Tetrodotoxin or nifedipine abrogated the effects of IC, C-Ch and PE but did not influence the effect of gamma-interferon on C2 synthesis.
(16) Preincubation of rIL-1 with a specific antibody abrogated and heat-inactivation destroyed this activity.
(17) This IFN-gamma-mediated suppression was monocyte dependent because it was completely abrogated by monocyte, but not T cell depletion.
(18) In contrast, these responses were both abrogated by hyperpolarization with the K+ ionophore valinomycin.
(19) Dilution of the latter detergent lysate with phosphate buffered saline exhibited no effect on the detection of the two additional components, while further treatment of the lysate with NP-40 buffer abrogated them to be detected.
(20) Release was abrogated by omission of myeloperoxidase or H2O2, heating of MPO, or addition of azide, cyanide, or catalase.
Authoritative
Definition:
(a.) Having, or proceeding from, due authority; entitled to obedience, credit, or acceptance; determinate; commanding.
(a.) Having an air of authority; positive; dictatorial; peremptory; as, an authoritative tone.
Example Sentences:
(1) Alongside that we want authoritative figures for the future."
(2) Authoritative guidelines are needed to guide clinical practice and to evaluate research.
(3) magazine is planning, for the first time in its 54-year history, an authoritative guide to British universities.
(4) Given the pressure on MP’s time, they tend to specialise on one or two countries if they pay any great attention to foreign affairs – only a very few, like the excellent Mike Gapes, can talk authoritatively about foreign policy across the piece.
(5) "I believe Australians have a right to know, a right to authoritative, independent and accurate information on climate change," Flannery told a press conference in Melbourne.
(6) The most authoritative account of Mitchell's side of his confrontation with the police was published by the Sunday Telegraph .
(7) The government wanted unclassified but authoritative intelligence material to advance its position.
(8) These people would make the US government’s authoritative count of people killed by police.
(9) As these are now being finalized and not yet approved for release, INR can only highlight the contents of this concise, authoritative document, which should become an indispensable handbook on AIDS for nurses and other health personnel when available.
(10) Liberal Democrat MP Andrew George, on the health select committee, told the BBC: "Most of the informed and authoritative commentators on this all agree this might result in a race to the bottom, and it certainly will.
(11) Human Rights Watch argued that “this authoritative report rightly condemns the horrific patterns of torture, arbitrary detention, and indefinite conscription that are prompting so many Eritreans to flee their country”.
(12) Nice describes itself as follows: “We provide independent, authoritative and evidence-based guidance on the most effective ways to prevent, diagnose and treat disease and ill health …” The medical profession should thus expect Nice to base its findings on full data disclosure and independently evaluated cost-benefit of statins.
(13) Neumann, the author of an authoritative study comparing prison regimes for terrorist prisoners in 15 countries, said there was a trade-off involved but he thought the current British dispersal system was probably the best way of tackling the issue.
(14) Led by Commander Steve Rodhouse, Operation Connect is trawling the Scotland Yard intelligence bank, and information from local authorities, schools and health authorites, to produce a centralised database of the most harmful gang members.
(15) There is no authoritative way to assess a government's record and, I guess, more time needs to pass for me fully to digest the history of the Labour years.
(16) This is the first of five reports on the nature and uses of PET that have been prepared for the American Medical Association's Council on Scientific Affairs by an authoritative panel.
(17) The purpose is to assist busy practitioners, students, researchers, or scholars to stay abreast of these items of progress in radiology that have recently achieved a substantial degree of authoritative acceptance.
(18) Islamic State (Isis), Syrian government forces, both sides in the conflict in eastern Ukraine and Saudi jets attacking targets in Yemen have all used cluster bombs and rockets banned by international treaty, according to an authoritative new report .
(19) The Perugia Division of Cancer Research (DCR) owes much to HLS because he was always ready with advice and help of every nature and because the Perugia Quadrennial International Conferences on Cancer (PQICC) had their beginning through his will and always enjoyed his authoritative approval and aid.
(20) The PSIS is a 68-item Likert-type questionnaire which asks patients to specify the skills which they believe belong to the psychiatrist's authoritative domain.