(v. t.) To annul by an authoritative act; to abolish by the authority of the maker or his successor; to repeal; -- applied to the repeal of laws, decrees, ordinances, the abolition of customs, etc.
(v. t.) To put an end to; to do away with.
Example Sentences:
(1) Although Jeggo's Chinese hamster ovary cells were more responsive to mAMSA, novo still abrogated mAMSA toxicity in the mutant cells as well as in the parental Chinese hamster ovary cells 2,4-Dinitrophenol acted similarly to novo with respect to mAMSA killing, but neither compound reduced the ATP content of V79 cells.
(2) LPS also abrogated the ability of recombinant interferon-gamma (r.IFN-gamma) to enhance macrophage larvicidal activity.
(3) Release of 51Cr was apparently a function of immune thymus-derived lymphocytes (T cells) because it was abrogated by prior incubation of spleen cells with anti-thymus antiserum and complement but was undiminished by passage of spleen cells through nylon-wool columns.
(4) In contrast, insertion of a pre-S(1) sequence between HBcAg residues 75 and 83 abrogated recognition of HBcAg by 5 of 6 anti-HBc monoclonal antibodies and diminished recognition by human polyclonal anti-HBc.
(5) Furthermore, exogenous IL-1, IL-2, IL-4, interferon-gamma, or a rat Con A supernatant failed to abrogate DFMO inhibition.
(6) A T cell was responsible for the suppressive effects on LAK generation because suppression was abrogated by treatment of alloimmune cells with anti-T serum plus complement.
(7) Inhibitors of DC clustering, including trypsin, paraformaldehyde, and tunicamycin, abrogated the ability of DC to support antigen presentation and lectin-mediated proliferation.
(8) Bound fluorescyl ligand, increased ionic strength (0.5 M NaCl) or basic pH (greater than 8.0) abrogated cryoprecipitation.
(9) One of the renal antigens recognized by 2B4.14.1 was identified as Tamm-Horsfall glycoprotein (THGP), based on the ability of the antibody to recognize THGP in western immunoblots and the abrogation of immunohistologic reactivity of the antibody by preincubation with purified THGP.
(10) Furthermore, treatment of AC with lysosomotropic agents abrogated thymocyte proliferation induced by PE but not SEB.
(11) Pretreatment with OKT3, together with a monoclonal anti-DR antibody and complement, did not abrogate the T-colony forming capacity.
(12) Resistance of the rat induced by C. liquefaciens to tumor cells was also abrogated by Trypan Blue treatment just 1 day before tumor cell inoculation.
(13) Serum SIRS-inducing activity was abrogated by treatment with proteinase K or boiling, but was not affected by dialysis, acidification to pH 2, or heating to 56 degrees C. This serum factor could be distinguished functionally and antigenically from SIRS and from interferon (IFN) alpha or IFN gamma.
(14) It is shown that while not affecting other mononuclear cells viability, this IT is capable of selectively destroying human monocytes after 24 h exposure thus resulting in the abrogation of monocyte support for PHA reactivity in mononuclear cell preparations.
(15) Tetrodotoxin or nifedipine abrogated the effects of IC, C-Ch and PE but did not influence the effect of gamma-interferon on C2 synthesis.
(16) Preincubation of rIL-1 with a specific antibody abrogated and heat-inactivation destroyed this activity.
(17) This IFN-gamma-mediated suppression was monocyte dependent because it was completely abrogated by monocyte, but not T cell depletion.
(18) In contrast, these responses were both abrogated by hyperpolarization with the K+ ionophore valinomycin.
(19) Dilution of the latter detergent lysate with phosphate buffered saline exhibited no effect on the detection of the two additional components, while further treatment of the lysate with NP-40 buffer abrogated them to be detected.
(20) Release was abrogated by omission of myeloperoxidase or H2O2, heating of MPO, or addition of azide, cyanide, or catalase.
Supersede
Definition:
(v. t.) To come, or be placed, in the room of; to replace.
(v. t.) To displace, or set aside, and put another in place of; as, to supersede an officer.
(v. t.) To make void, inefficacious, or useless, by superior power, or by coming in the place of; to set aside; to render unnecessary; to suspend; to stay.
(v. t.) To omit; to forbear.
Example Sentences:
(1) It was superseded by a new version earlier this year.
(2) At higher [Ca2+]i, the effect of K+ channels on Em is superseded by opening of nonselective cation channels, producing depolarization.
(3) The cephalic signal can be superseded by juvenile hormone, whose presence is necessary for each follicle to become vitellogenic.
(4) In an age of economic crisis, the tacit assumption of the governing class is that political reform is superseded by the growing demand for security.
(5) Radiological studies of Willis' circle morphology are mainly performed in search of intracerebral aneurysms, and for this purpose digital imaging has not superseded conventional radiology.
(6) This extracellular action may supersede the action of collagenase and the activity of these different enzymes would thus be regulated by changes in the nature of this microenvironment.
(7) Indeed, by the mid-17th century, Caravaggism was already out of favour in Rome and had been superseded by a Raphaelesque classicism, practised most gracefully by Annibale Carracci.
(8) In spite of his life seeming superficially great, in spite of all the praise and accolades, in spite of all the loving friends and family, there is a predominant voice in the mind of an addict that supersedes all reason and that voice wants you dead.
(9) During the period under review the Phemister procedure was replaced by percutaneous epiphysiodesis, and orthoroentgenogram was superseded by computed tomography (CT) scanning.
(10) Indeed, by analogy with anti-hypertensive therapy, enzyme inhibitors could eventually supersede receptor antagonists for the treatment of acid-related diseases.
(11) Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed-independent mode of maintenance.
(12) Early excision-graft of burned hands seems to have totally superseded the conventional method of progressive detorsion often with late grafting.
(13) Graphene is claimed by some as an innovation that will prove as revolutionary as the silicon chip, or even plastics, both of which it may supersede.
(14) Stupid, sadistic, public-school educated, a former Black and Tan and one-time professional strikebreaker in the United States, "wanted in New Orleans for the murder of a coloured woman", it's tempting to see him as a satirical portrait of the archetypal hero of the moribund thrillers that Ambler was so determined to supersede, unmasked and revealed for the cryptofascist brute he really is.
(15) If you are in this position, your rights also supersede what are commonly known as "squatters' rights".
(16) Streptomycin undoubtedly will be improved upon and superseded by some other agent in the future, giving us better control of this disease and possibly enabling us to eradicate it.
(17) The application of this combination of techniques supersedes the traditional approaches (gel filtration on polydextran gels, electrophoresis) in specificity and speed.
(18) People and companies are entitled to acquire and hold private assets, but there are times – as in the run-up to the Olympics, as in the period of urban reconstruction after the second world war – when the public good must supersede the rights of those who wish to retain and profit from private assets.
(19) It is designed as an objective system--superseding former weighting processes, which were influenced by ambition, prestige, prejudice and narrow politics--and has sufficient flexibility to accommodate both the anticipated and the unforeseen.
(20) The principle that the best management is resection and exteriorisation of the ends, which was developed in the early 1970s, has been superseded by the realisation that resection and primary anastomosis can be safe in a well-resuscitated infant in whom the bowel ends appear viable.