(1) This change in cholesterol esterification appears to be the result of reductions in the activity of acyl-CoA:cholesterol acyltransferase (ACAT) in the endoplasmic reticulum of the macrophages incubated with the n-3 polyunsaturated fatty acids.
(2) Acaterin also inhibited ACAT activity in the rat liver microsomes by 50% at a concentration of 120 microM.
(3) This mechanism, which is activated by changes in culture density, coordinately regulates the activities of HMG-CoA reductase and acyl-CoA:cholesterol acyltransferase (ACAT).
(4) These results suggest that ACAT activity in microsomes was affected not only by the amount of microsomal cholesterol, but also by an extra-microsomal soluble protein such as lipoproteins.
(5) ACAT activity was also determined in microsomes prepared from twenty human liver samples obtained at surgery with in vivo warm ischaemia times ranging from 5-120 min.
(6) In sterol-free medium, if sterol synthesis is blocked by specific enzyme inhibitors or through mutation, the ACAT activation by cycloheximide is again abolished.
(7) Kinetic studies indicate that DL-MA is an uncompetitive inhibitor of ACAT.
(8) The results suggest that ACAT activity in CaCo-2 cells is stimulated by cholesterol delivered to the cells by way of taurocholate micelles.
(9) Furthermore, the large beta-VLDL had a higher ACAT-stimulatory potential than the smaller beta-VLDL.
(10) A decrease in HMG-CoA reductase and an increase ACAT activity was observed compared with the corresponding values from both the groups fed on a standard diet and a fat supplemented diet with no cholesterol.
(11) The IC50 values of enniatins D, E and F for ACAT activity in an enzyme assay using rat liver microsomes were calculated to be 87, 57 and 40 microM, respectively.
(12) Except in adult rats, the HG diet always raises hepatic ACAT activity more than the HCO diet or the Purina Chow.
(13) In contrast, ACAT activity in NPD fibroblasts (cell lines from four different patients) began to increase between 6 and 12 h after serum addition, reaching levels up to 50% of normal values at 24 h. ACAT activity in NPC and NPD cell extracts could not be stimulated by preincubation with normal cell homogenates, nor was complementation between NPC and NPD homogenates observed.
(14) Apparent ACAT activity levels increased significantly in nude mouse tumours and in foetal and postnatal rat pancreata and also in postnatal liver.
(15) A 5% cholesterol diet for 3 hr produced an increase in the microsomal and plasmatic cholesterol content, a decrease in HMG-CoA reductase activity and a concomitant increase in ACAT activity.
(16) The effect of CDCA, UDCA and the cyclopropyl analogues was also tested with respect to HMG-CoA reductase and acylCoA cholesterol acyltransferase (ACAT) activities.
(17) The structure of purpactins, novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, was determined by spectroscopic analyses.
(18) The enhanced ACAT activity obtained by freezing was at least partly explained by a transfer of unesterified cholesterol to the microsomal fraction and possibly also by making the substrate(s) more available to the enzyme.
(19) Under these experimental conditions, treatment with insulin or with the ACAT inhibitor CL-277082 significantly reduced the plasma cholesterol to levels measured in nondiabetic rats fed the same high fat diet.
(20) DL-MA inhibited acyl CoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) activity in the mucosal microsomes, with 50% inhibition occurring at approximately 0.5 microM.
Cater
Definition:
(n.) A provider; a purveyor; a caterer.
(n.) To provide food; to buy, procure, or prepare provisions.
(n.) By extension: To supply what is needed or desired, at theatrical or musical entertainments; -- followed by for or to.
(n.) The four of cards or dice.
(v. t.) To cut diagonally.
Example Sentences:
(1) Norwich Ownership Delia Smith and her husband Michael Wynn Jones own 53.1% of the club’s shares; deputy chairman Michael Foulger owns approximately 16% Gate receipts £12m Broadcasting and media £70m Catering £4m Commercial & other income £12m Net debt Not stated; £2.7m bank overdraft, no directors’ loans.
(2) Kurdish officials on Thursday demanded more help in catering for refugees.
(3) Many shops are now catering to these high spenders.
(4) Twenty years ago, before the reign of Charlie Mayfield, the present CEO, the company's cleaners and caterers were all outsourced to save money.
(5) The truth was that he had failed his maths O-level at his local school and completed a City and Guilds in catering at Glasgow College of Food Technology.
(6) It is suggested that a transcultural approach be adopted in managing cases in which the parents feel particularly anxious and uncomfortable about prematurely erupted teeth in order to cater for the social well-being of the child and family.
(7) This family-run stables genuinely caters for all abilities and you get to ride straight out on to Dartmoor.
(8) Quantitative observations were made of 200 groups in bars catering for young adults.
(9) The Royal School for Deaf Children, Margate, caters for children with a wide range of needs; screening involving a single-assessment structure for all pupils is felt to be inappropriate.
(10) "I thought the Korean burger was quite good," the hipster goes on, without much kimchi-fired enthusiasm, "but I think a lot of people don't make their food with enough shbang … They kind of cater to the middle of the road."
(11) And the letters themselves are detailed to a fault, telling ministers far more than they need to know about the importance of the Patagonian toothfish, the single farm payment and the recent report of the Local Authority Caterers Association on school meals.
(12) Turner Contemporary, which opened in 2011, has helped transform Margate into an emerging destination for the arts , while new hotels, such as the Albion House in nearby Ramsgate , cater for visitors looking for boutique-style accommodation.
(13) Some can't afford their own uniforms or pencil tins and we have to teach them the most basic things, like how to queue up for dinner,” said Cater-Whitham.
(14) British commuters to mainland Europe and short-term contractors who work on the continent say the British proposal does not cater for them.
(15) PHE will continue to support local authorities to provide effective weight management services, to influence the regulation of fast food outlets and provide healthier catering in hospitals and schools, which will all help people to lose weight.
(16) A study was undertaken to determine the incidence of systemic postoperative complications and the operative mortality of patients undergoing elective aortic surgery in a hospital that caters to a homogeneous population group.
(17) They weren't aware that MSG was what they'd liked in Japan - but the US Army catering staff noticed that their men enjoyed the leftover ration packs of the demobilised Japanese Army much more than they did their own, and began to ask why.
(18) Our agreement with the LLDC will see West Ham make a substantial capital contribution towards the conversion works of a stadium on top of a multimillion-pound annual usage fee, a share of food and catering sales, plus provide extra value to the naming rights agreement.
(19) Viravaidya maintains that the tourist sex industry (catering to Americans, Europeans and Japanese) is only a contributory factor of the epidemic.
(20) During Mr Thompson's big speech in Banff three years ago, after which he was marked out by many as a DG in waiting, he laid out a vision of a multichannel age in which the BBC would move from mixed genre, high audience channels to a range of digital services catering for niche audiences.