(v. t.) To heap up in a mass; to pile up; to collect or bring together; to amass; as, to accumulate a sum of money.
(v. i.) To grow or increase in quantity or number; to increase greatly.
(a.) Collected; accumulated.
Example Sentences:
(1) The accumulation of lipids and enzymes such as simple estarase, lipase, beta-HDH, alpha-GDH and NADPH-reductase in those areas, suggests that lipids are not a simple excretory product.
(2) After 4 to 6 hours of recirculation, accumulation of vasoactive amine, 5-hydroxytryptamine, its major metabolite, 5-hydroxyindole acetic acid, and its precursor amino acid, tryptophan were detected.
(3) The rate of accumulation of degraded LDL products was lower in collagen gel cultures, but the final levels achieved were the same in the two substrata.
(4) Based on several previous studies, which demonstrated that sorbitol accumulation in human red blood cells (RBCs) was a function of ambient glucose concentrations, either in vitro or in vivo, our investigations were conducted to determine if RBC sorbitol accumulation would correlate with sorbitol accumulation in lens and nerve tissue of diabetic rats; the effect of sorbinil in reducing sorbitol levels in lens and nerve tissue of diabetic rats would be reflected by changes in RBC sorbitol; and sorbinil would reduce RBC sorbitol in diabetic man.
(5) These effects are similar to those reported for AVP and phorbol esters, activators of protein kinase C. Forskolin and isoproterenol, which induce cAMP accumulation, activated extractable topoisomerase II (maximum 5-15 min after treatment), but not topoisomerase I. Permeable cyclic nucleotide analogs dBcAMP and 8BrcGMP selectively activated extractable topoisomerase II and topoisomerase I activities, respectively.
(6) The data support the conclusion that accumulation of lipid II is responsible in some way for the hypersensitivity of delta rfbA mutants to SDS.
(7) In addition, the guanosine 3',5'-cyclic monophosphate accumulation response was less impressive in glomeruli than the guanylate cyclase response in IMCD tissue.
(8) It was also shown that after a shock at 44 degrees C teratocarcinoma cells were able to accumulate anomalous amounts of hsp 70 despite hsp 70 synthesis inhibition.
(9) At 24 or 48 hours after ischemia, 63Ni, 99TcO4, and 22Na were preferentially concentrated in the damaged striatum and hippocampus, whereas 65Zn, 59Fe, 32PO4, and 147Pm did not accumulate in irreversibly injured tissue.
(10) Aside from these characteristic findings of HCC, it was important to reveal the following features for the diagnosis of well differentiated type of small HCC: variable thickening or distortion of trabecular structure in association with nuclear crowding, acinar formation, selective cytoplasmic accumulation of Mallory bodies, nuclear abnormalities consisting of thickening of nucleolus, hepatic cords in close contact with bile ducts or blood vessels, and hepatocytes growing in a fibrous environment.
(11) They are capable of synthesis and accumulation of glycogen and responsible for its transfer to sites of more intense metabolism (growth, bud, blastema).
(12) Our results show that large complex lipid bodies and extensive accumulations of glycogen are valuable indicators of a functionally suppressed chief cell in atrophic parathyroid glands.
(13) Much information has accumulated on the isolation and characterization of a heterogeneous group of molecules that inhibit one or more of the bioactivities of interleukin 1.
(14) The mechanism by which K+ accumulates in the follicle was insensitive to ouabain, so that a typical Na+, K(+)-ATPase mechanism does not appear to be involved.
(15) The data shows a dissociation between ferritin synthesis, cellular accumulation and secretion for which the mechanisms have still to be elucidated.
(16) The rate of accumulation was highest late in infection and only the slower migrating form incorporates significant amounts of glucosamine.
(17) Initiation of the alternative pathway by the cryptococcal capsule is characterized by a lag in C3 accumulation and the appearance of a limited number of focal initiation sites which resemble those observed when the alternative pathway is activated by zymosan and nonencapsulated cryptococci.
(18) Accumulating evidence indicates that for most tumors, the switch to the angiogenic phenotype depends upon the outcome of a balance between angiogenic stimulators and angiogenic inhibitors, both of which may be produced by tumor cells and perhaps by certain host cells.
(19) The aim of our experiments was to investigate firstly whether during an acute inflammatory process platelets accumulate in the inflamed area and secondly whether the inflammation has an effect on the properties of the platelets.
(20) The accumulated evidence would strongly favor an affirmative answer.
Heap
Definition:
(n.) A crowd; a throng; a multitude or great number of persons.
(n.) A great number or large quantity of things not placed in a pile.
(n.) A pile or mass; a collection of things laid in a body, or thrown together so as to form an elevation; as, a heap of earth or stones.
(v. t.) To collect in great quantity; to amass; to lay up; to accumulate; -- usually with up; as, to heap up treasures.
(v. t.) To throw or lay in a heap; to make a heap of; to pile; as, to heap stones; -- often with up; as, to heap up earth; or with on; as, to heap on wood or coal.
(v. t.) To form or round into a heap, as in measuring; to fill (a measure) more than even full.
Example Sentences:
(1) If Lagarde had been placed under formal investigation in the Tapie case, it would have risked weakening her position and further embarrassing both the IMF and France by heaping more judicial worries on a key figure on the international stage.
(2) In autumn, leaf-heaps composted themselves on sunken patios, and were shovelled up by irritated owners of basement flats.
(3) Across a dusty lot sits a heap of scrap metal, patrolled by a couple of emaciated dogs, while a toddler squats in the street, examining the sole of a discarded shoe.
(4) Despite the praise and awards heaped on him Yunus has not become one of those leaders who checks out how important you are before deciding how much of his time you are worth.
(5) Not to mention the files they may have already shredded.” One core problem is that too many expectations have been heaped on a trial that cannot bear them all.
(6) She responded with Mrs Schofield's GCSE , which heaped up all the grisly murders in Shakespeare.
(7) There's been so much abuse heaped upon these communities, and so much rightful anger at the people who stole their lands.
(8) It has been established experimentally that the Opisthorchis metacercaria in fish muscles were killed at -28 degrees S in 15-20 h., at -35 degrees C in 8 h. and at -40 degrees C in 2 h. The period of fish freezing becomes much longer when it is stored in snow-covered heaps, which may be the cause of Opisthorchis invasion of wild and domestic carnivorous animals.
(9) Tayyab Mahmood Jafri, part of the large team of prosecution lawyers, heaped scorn on yet another discovery of explosives.
(10) In the 1980s she was near the bottom of the heap in popularity among US first ladies - coming 36th out of 37 in a 1993 opinion poll.
(11) The technology giant heaped pressure on its rivals with a cheaper iPad 2 priced at $399 (£254).
(12) Unless those at the bottom of the heap can represent themselves, and the inarticulate will not know how to woo judges, they will be outlaws.
(13) Gaddafi, as vigilant keeper of the flame, kept a weather eye open, heaping privileges on some and prestige on others in order to consolidate alliances and plaster over any cracks that threatened to appear.
(14) He went on to heap blame on Corrie for her own killing, arguing that, contrary to what "any reasonable person would have done", she "chose to put herself in danger" by trying to impede "a military activity meant to prevent terrorist activity".
(15) The far rightwing La Gaceta on a front page editorial heaped insults on the politicians who had voted for the ban, singling out the man who is likely to become the next Catalan president as "a separatist who hates everything Spanish".
(16) After weeks of open criticism, Die Welt also heaped praise on the German coaching team’s tactical flexibility.
(17) Pseudopolyps which represent polypoid oedematous tags, regenerating mucosal islands between ulcerations or heaped-up granulation tissue covered by epithelium, are a common sequela of ulcerative colitis and may also occur secondary to granulomatous colitis.
(18) Yet the Welsh government is set on building more roads like the M4 extension that will bring more harmful pollution and more congestion.” Alan Heaps, who runs a woodwork business from his house on the A472, agreed that radical action was needed.
(19) In an attempt to reduce the numbers of this pathogen in this sewage end product, the survival of L. monocytogenes was monitored in a heap of sewage sludge cake stored for over 23 weeks on farm land.
(20) The millionaires boom offers little consolation to Africans at the bottom of the heap: South Africa remains one of the most unequal societies in the world.