(n.) A compound of aniline with acetyl, used to allay fever or pain; -- called also antifebrine.
Example Sentences:
(1) Acetanilide levels in plasma determined by the selected ion monitoring method were significantly lower than those measured by spectrophotometry.
(2) A mould which was isolated from a solution of paracetamol was identified as a Penicillium species and was found to possess the ability to utilise a series of substituted acetanilides, including paracetamol (4-hydroxyacetanilide), phenacetin (4-ethoxyacetanilide) and metacetamol (3-hydroxyacetanilide) as sole carbon sources for growth.
(3) The major metabolites of acetanilide are shown not to interfere with these assays and the results suggest the possible presence of a new metabolite of acetanilide.
(4) Oxidate pathways yielded 2,4-diacetylaminophenol (O-demethylation), 5-hydroxy-2,4-diacetylaminoanisole (ring hydroxylation), and 2-methoxy-5-(glycol-amido)acetanilide or its isomer (omega-oxidation).
(5) 2 The results suggest that there is no significant change in hepatic oxidation of acetanilide with age.
(6) The main molecular and catalytic properties of an acetanilide-hydrolyzing enzyme from Pseudomonas acidovorans AE 1, purified to a homogeneous state, were investigated.
(7) Acetanilide hydroxylase (AcOH) activity was measured using an HPLC method with more than 500-fold greater sensitivity than previously described procedures.
(8) The data indicate that, at the doses studied: the primary route of aniline metabolism is via sequential acetylation and hydroxylation, and deacetylation plays a significant role in the disposition of acetanilide.
(9) Alachlor [2-chloro-2',6'-diethyl-N-(methoxymethyl)acetanilide] was determined by hydrolysis to 2,6-diethylaniline with 6N HCl and quantitation of the heptafluorobutyryl derivative by gas chromatography with electron capture detection.
(10) Hydrolysis rates were decreased by various para substitutions of acetanilide.
(11) On the other hand, N-acetates, such as acetanilide and p-acetaminophenol, and no contractile action on the ileum.
(12) A comparative study of the metabolism of [acetyl-14C]phenacetin, [acetyl-14C]methacetin, [acetyl-14C]paracetamol and [acetyl=14C]acetanilide in the rat is reported.
(13) Chloro substitution in the acyl moiety of acetanilide also reduced the rate of hydrolysis.
(14) The structure of the main metabolite of SX-PP 16 (46% of urinary excretion) was elucidated as 3-bromo-4-amino-5-mercapturyl-acetanilid.
(15) Acetanilide with the three hydrogens of the acetyl group replaced by deuterium was administered to 9 human volunteers (50 mg p.o.)
(16) Cells transfected with a pMT2-based vector expressing P450IA2 cDNA (pMT2-IA2) had high acetanilide-4-hydroxylase activity and very low aryl hydrocarbon hydroxylase (AHH) activity.
(17) Acetanilide is a rather specific substrate for RL2, whereas RH1 has the highest specific activity for butanilicaine.
(18) Acetanilides altered the relative cation permeability from Rb (1.25) greater than K (1.0) greater than Cs (0.60) greater than NaequalsLi (0.07) to K (1.0) greater than Rb (0.71) greater than Cs (0.31) greater than NaequalsLi (0.00).
(19) This shift in relative cation permeability is interpreter, in terms of Eisenman's theory of membrane permselectivity, as indicating that acetanilides increase the anionic field strength of the membrane.
(20) The results indicate that Fenclor 64 evoked a "mixed type" induction in virgin as well as in pregnant rabbits since it increased liver weight, cytochrome P-450 levels, as well as p-nitro-anisole-O-demethylase and acetanilide-hydroxylase.
Amide
Definition:
(n.) A compound formed by the union of amidogen with an acid element or radical. It may also be regarded as ammonia in which one or more hydrogen atoms have been replaced by an acid atom or radical.
Example Sentences:
(1) Since the start of this week, markets have been more cautious, with bond yields in Spain reaching their highest levels in four months on Tuesday amid concern about the scale of the austerity measures being imposed by the government and fears that the country might need a bailout.
(2) Businesses fleeing Brexit will head to New York not EU, warns LSE chief Read more Amid attempts by Frankfurt, Paris and Dublin to catch possible fallout from London, Sir Jon Cunliffe said it was highly unlikely that any EU centre could replicate the services offered by the UK’s financial services industry.
(3) Amid the passionate discussion at the NDA meeting, the two women began to develop a plan.
(4) Amid the acrimony of the failed debate on the Malaysia Agreement, something was missed or forgotten: many in the left had changed their mind.
(5) The presence of a previously unreported dipeptide transport mechanism within blood leukocytes and the selective enrichment of the granule enzyme, DPPI, within cytotoxic effector cells of lymphoid or myeloid lineage appear to afford a unique mechanism for the targeting of immunotherapeutic reagents composed of simple dipeptide esters or amides.
(6) Seconds later the camera turns away as what sounds like at least 15 gunshots are fired amid bystanders’ screams.
(7) Amid all of the worry about her health, the difficult decisions around the surgery, and how to explain everything to the children, the practicalities of postponing the holiday was a relatively minor consideration.
(8) The alignment of Clinton’s Iowa team, all but guaranteeing a declaration of her official campaign before the end of next month, was coming into view amid reports that she was due to address by the end of the week controversy over her use of a private email account as secretary of state.
(9) The aza analogue (RS)-3-hydroxy-2,5-pyrrolidinedione-3-acetic acid (6) of the five-membered citric anhydride (2) was prepared in the sequence citric acid----2-phenyl-1,3-dioxolan-4-one-5,5-diacetic acid (1)----citric acid beta-amide (3)----6 and used to resolve ambiguities in the mechanism of the citrate synthase reaction.
(10) These results, in addition to binding studies with the active site titrant N2-(5-dimethylaminonaphthalene-1-sulfonyl)arginine N-(3-ethyl-1,5-pentanediyl)amide, indicate that binding interactions at the catalytic site of Thrombin Quick I are unaltered.
(11) Displacement of the active ester in the gel thus formed by various ligands containing aliphatic amino groups resulted in the formation of stable amid bonds between the ligands and the polyacrylamide gel.
(12) Arsenal’s 10 men fall at the first hurdle against Dinamo Zagreb Read more This win, even against such feeble opponents, was celebrated, with the locals chorusing their manager’s name amid a wave of relief given so much of the team’s domestic campaign to date has been dismal.
(13) Free radicals formed by the reactions of OH radicals with amides and their N-methylated derivatives in aqueous solutions have been studied.
(14) In EastEnders , the mystery surrounding the identity of Kat's secret squeeze continues amid the grinding of narrative levers and the death rattle of overflogged script-horses.
(15) Guanine nucleotides (GTP-gamma-S, GDP-beta-S) decreased the binding of 125I-labelled GLP-1(7-36)amide to rat lung membranes as was found for GLP-1(7-36)amide receptors in RINm5F cells which were also shown to be coupled to the adenylate cyclase system.
(16) The ester group in the N-acyloxymethyl derivatives was readily hydrolyzed by plasma enzymes to yield the N-hydroxymethyl amide, which subsequently decomposed to the parent amide.
(17) Soon after the takeover, PFD creative director Sue Douglas, the former Sunday Express editor, left amid reports that the company wasn't big enough for "two alpha females in Chanel".
(18) Pancreastatin is a 49 amino acid peptide with a C-terminal glycine amide originally isolated from porcine pancreas.
(19) The announcement comes amid mounting frustration in the international community over Israel’s continued settlement activity, regarded by many countries as illegal.
(20) Losing Murphy is a blow to the Oscars which has struggled to liven up its image amid a general decline in its TV ratings over the last couple of decades and a rush of awards shows that appeal to younger crowds, such as the MTV Movie Awards.