What's the difference between ache and agony?

Ache


Definition:

  • (n.) A name given to several species of plants; as, smallage, wild celery, parsley.
  • (v. i.) Continued pain, as distinguished from sudden twinges, or spasmodic pain. "Such an ache in my bones."
  • (v. i.) To suffer pain; to have, or be in, pain, or in continued pain; to be distressed.

Example Sentences:

  • (1) Analysis of conjugated discharges ACHs showed that they appeared predominantly periodically (87% of cases).
  • (2) By means of two monoclonal antibodies, which were directed against external and internal acetylcholine (ACh) receptor epitopes, we were able to visualize ACh-receptors on OHCs.
  • (3) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
  • (4) ACh released from the vesicular fraction was about 100-fold more than could be accounted for by miniature end-plate potentials; possible causes of this overestimate are discussed.
  • (5) The nature of the putative autoantigen in Graves' ophthalmopathy (Go) remains an enigma but the sequence similarity between thyroglobulin (Tg) and acetylcholinesterase (ACHE) provides a rationale for epitopes which are common to the thyroid gland and the eye orbit.
  • (6) The response selectivity, such as orientation and direction selectivities, of cortical cells was not affected by the depletion of ACh.
  • (7) Acetylcholine (ACh) induces a K+ current in rabbit cardiac Purkinje fibres.
  • (8) This paper examines the chiral nature of the covalent conjugates formed upon reaction of acetylcholinesterase (AchE) with enantiomeric cycloheptyl, isopropyl, and 3,3-dimethylbutyl methylphosphonyl thiocholines.
  • (9) The results suggest that AH5183 does not bind to the ACh transporter recognition site on the outside of the vesicle membrane, and thus it might inhibit allosterically.
  • (10) In the absence of prostigmine, increasing the concentration of ACh in the synaptic cleft did not change the time constant for decay of end-plate currents.
  • (11) We examined the effect of propentofylline on two adenosine actions in the rat hippocampus; the A2-mediated stimulation of 3H-cAMP accumulation and the A1-mediated inhibition of 3H-ACh release.
  • (12) Neuromuscular transmission and muscle sensitivity to acetylcholine (ACh) were studied in vitro in soleus and extensor digitorium longus (EDL) from 6 hr to 4 months after the injection of toxin.3.
  • (13) These results suggest that different molecular factors might mediate the effects on GABA and ACh synthesis.
  • (14) At the adult neuromuscular junction, acetylcholine (ACh) receptors are highly localized at the subsynaptic membrane, whereas, embryonic myotubes before innervation have receptors distributed over the entire surface.
  • (15) Nitric oxide (NO) induced tetrodotoxin-resistant NANC relaxation, similar to that induced by electrical stimulation or acetylcholine (ACh).
  • (16) In senescent rats, however, the proportions of salt-soluble and detergent-soluble AChE may differ from those in young rats.
  • (17) In addition, in these animals blood AChE and butyrylcholine esterase (BuChE) activities were determined.
  • (18) Roles of the LHA dopaminergic and cholinergic systems in CTS learning were investigated by electrophoretic application of dopamine (DA) and acetylcholine (ACh), and their antagonists.
  • (19) The absence of ACh therefore appears to reduce the cortical response to stimulation, while background activity values do not change.
  • (20) As stimulus rate was decreased, blockade of secretion resulted from fewer stimuli but no difference in ACh content was found between stimulated and unstimulated glands.

Agony


Definition:

  • (n.) Violent contest or striving.
  • (n.) Pain so extreme as to cause writhing or contortions of the body, similar to those made in the athletic contests in Greece; and hence, extreme pain of mind or body; anguish; paroxysm of grief; specifically, the sufferings of Christ in the garden of Gethsemane.
  • (n.) Paroxysm of joy; keen emotion.
  • (n.) The last struggle of life; death struggle.

Example Sentences:

  • (1) "The new feminine ideal is of egg-smooth perfection from hairline to toes," she writes, describing the exquisite agony of having her fingers, arms, back, buttocks and nostrils waxed.
  • (2) It has been awfully hard-won, carved slowly out of a big block of human agony.
  • (3) Her agony and her rapture stay interior, and they flip-flop like nerves in this beautiful, grave black-and-white movie.
  • (4) Those who remember the Two Davids of the 1987 SDP-Liberal Alliance will recall the exquisite agony only too well, cruelly captured by the Spitting Image puppet of little Steel perched in big Owen's pocket.
  • (5) Using male and female Wistar rats, pituitary response to cardiac and respiratory failure type (CFT and RFT) sudden death caused by the intravenous administration of KC1 and SCC, respectively, was examined by analyzing variation in pituitary immunoreactive beta-endorphin (IR-beta-EP) levels determined by radioimmunoassay after death and in circulating IR-beta-EP levels during periods of agony.
  • (6) I was in the surgical ward at Westmorland General Hospital on Kendal Green, and it was agony.
  • (7) I'd go after work and he'd paint till 1 or 1.30 in the morning, and it was agony lying there on the floor.
  • (8) Evidently fuelled by the agony of losing a series twelve months ago when the trophy was almost within their grasp, they also had the teamwork, technique and experience to turn their quest for revenge into a reality.
  • (9) Facebook Twitter Pinterest Even those who’ve never seen a downhill ski race couldn’t help but sympathise with Bode Miller’s agony at missing out on a medal in what will surely be the last Olympic event of his career.
  • (10) "When the disaster was big enough," King writes, "agony and violent death had an enriching quality."
  • (11) Even at UCH, when no one was there for us and my father, having not slept for almost 30 hours, was pulling his hair out in agony, I tried to look at it all as a kind of comedy of errors."
  • (12) They were subject, of course, to the prison censor, but the agony over Winnie, and the passion of which that agony was a product, blazes through them.
  • (13) That he ended up in the dock in The Hague at all surprised many who have studied the man and his country's agony through the 1990s.
  • (14) Shawcross, however, maintains there was no bad intent and said for that reason he has not been tormenting himself about the moment he collided with Ramsey's right leg and left the teenager writhing in agony.
  • (15) He notes the uneven agony - 80% will land in developing countries.
  • (16) The poor animals are thrown back into the water to die in agony, a practice condemned by environmental campaigners.
  • (17) The rest was pure agony for the Australians, give or take a yellow card for Sonny Bill Williams, given for a dangerous tackle.
  • (18) The woman before you in agony pushing and pushing, losing all dignity, does not care one bit whether I am feeling alarmed at her screaming, worried about where I should be standing, wondering whether I should rub her back or try and make small talk between contractions.
  • (19) Litvinenko sipped “three or four times” from a cup of radioactive tea, and died in agony 23 days later, the inquiry heard last week.
  • (20) Our most excruciating agony is of not being noticed in the world.