(1) Astrocyte conditioned medium (ACM) enhanced the survival of neurons and the proliferation of astrocytes in embryonic cortical cultures grown in serum-free defined medium.
(2) Race 4 transconjugants containing avrB0 induced a dark brown necrotic HR within 24 h on the soybean cultivars Harosoy and Norchief, whereas race 4 transconjugants containing avrC induced a light brown necrotic HR within 48 h on the soybean cultivars Acme, Peking, Norchief, and Flambeau.
(3) Posterior fossa decompression with obex plugging (the Gardner operation) was the procedure of choice for SM-ACM and for idiopathic holocord syringomyelia.
(4) A variety of protected peptides up to tetradecapeptides have been chromatographed at pressures of 50 to 150 psi and obtained in analytically pure from within 2 to 4 h. With such commonly used protecting groups as N-benzyloxycarbonyl (Z), N-2-(p-biphenylyl)-2-propyloxycarbonyl (Bpoc), N-t-butyloxycarbonyl (Boc), O- and S-t-butyl (But), and S-acetamidomethyl (Acm), compounds were sufficiently soluble in chloroform, alcohols, acetic acid, or mixtures of these solvents for column loading.
(5) Material was fixed in buffered-formalin solution and embedded in metacrylate or Durcupan ACM.
(6) In a phase I-II study, 19 patients with acute lymphoid leukemia (ALL) and 8 patients with non-Hodgkin lymphoma (NHL) were given ACM alone according to the regimen designated treatment 1 described above.
(7) The lack of significant abnormalities in post-ictal polysomnograms corresponds to a functional integrity of the brainstem structures involved in the global organization of sleep and may represent a useful laboratory feature in the diagnosis of ACM.
(8) Proliferation of CFU-acm can be controlled by humoral factors and this allows us to conclude that they are not identical to CFUs and probably belong to the compartment of early hemopoietic cells of the granulocyte series.
(9) Sequential studies of the self-limited HgCl2 GN showed that glomerular PCA, proteinuria and glomerular fibrin deposits peaked concomitantly at the acme of the disease, suggesting that immunologically mediated glomerular damage had triggered the extrinsic coagulation pathway.
(10) The ACMS said the mining industry ads ignored the impacts of industrialisation, which it called “the fastest growing threat to the reef”.
(11) Conversely, the exposure of cells to the anthracycline compounds at 0 degree C resulted in almost complete disappearance of cell kill effects except with ACM; ACM retained substantial cell kill effects even at the given low temperature.
(12) With the MM cells, hyperthermia potentiated the cytotoxic effects of doxorubicin (ADM), daunorubicin, mitoxantrone (DHAD), and quelamycin but did not enhance that of aclacinomycin (ACM).
(13) These data lead us to conclude that ACM-DOX association partly reverses the DOX resistance at clinically achievable concentrations.
(14) The significance of these observations was discussed in terms of possible interactions at the level of ACM and CAF biotransformation and the potential for interactions of CAF with other xenobiotics.
(15) That triumphal speech was his apex, the acme, the zenith of his career.
(16) The therapeutic value of these compounds for established ACME remains uncertain.
(17) The structural basis of this bleeding disorder has been further assessed by studying the interaction of the following Val(12)-substituted human fibrinogen-like peptides with bovine thrombin in aqueous solution by use of two-dimensional NMR spectroscopy (including TRNOE): Ala-Asp-Ser-Gly-Glu-Gly-Asp(7)-Phe-Leu-Ala- Glu-Val(12)-Gly-Gly-Val-Arg(16)-Gly(17)-Pro-Arg-Val-NH2 (F16), Ala-Asp-Ser-Gly-Glu-Gly-Asp(7)-Phe-Leu-Ala-Glu-Val(12)-Gly-Gly-Val- Arg(16) (tF16), Ala-Asp-Ser-Gly-Glu-Cys(Acm)-Asp(7)-Phe-Leu-Ala-Glu-Val(12)-Gly-Gly-Val- Arg(16)-Gly(17)-Pro-Arg-Val-Cys(Acm)-NH2 (F17), and Ala-Asp-Ser-Gly-Glu-Cys(Acm)-Asp(7)-Phe-Leu-Ala-Glu-Val(12)-Gly-Gly- Val-Arg(16) (tF17).
(18) A sensitive enzyme immunoassay method (EIA) for an anticancer drug, aclacinomycin A (ACM), has been developed.
(19) A comparison of the ACM aa sequence with the aa sequences of other proteins in the NBRF data base reveals that ACM has strong similarity to the N-O-diacetylmuramidase secreted by the fungus Chalaropsis.
(20) None of the 8 patients suffering from ovarial cancer benefitted from ACM therapy.
Culmination
Definition:
(n.) The attainment of the highest point of altitude reached by a heavently body; passage across the meridian; transit.
(n.) Attainment or arrival at the highest pitch of glory, power, etc.
Example Sentences:
(1) Beckham's decision marks the culmination of a strategy aimed at preserving his brand long after the footballer has faded.
(2) A hypothetical scheme is presented that pursues the processes involved in invasion from the biochemical events generated by attachment of the parasite, to the steric rearrangement of red cell membrane proteins, which culminates in invasion.
(3) He'd later carry this over into Netflix's House Of Cards but before that, TV had already begun to emulate this new, bleak, antiheroic maturity with a cycle of dark, longform, acclaimed dramas, commencing with The Sopranos and culminating in Breaking Bad .
(4) Fox will be accompanied by the sporting director, Hendrik Almstadt, on the back of the 1-1 draw against Wycombe Wanderers in the FA Cup on Saturday, when their failure to beat a League Two side culminated in angry scenes involving the away supporters.
(5) It was found that: the two cell types have the same basal adenylate cyclase activity; prespore cells and prestalk cells are able to relay the extracellular cAMP signal equally well; intact prestalk cells show a threefold higher cAMP phosphodiesterase activity on the cell surface than prespore cells, whereas their cytosolic activity is the same; intact prestalk cells bind three to four times more cAMP than prespore cells; no large differences in cAMP metabolism and detection were observed between cells derived from migrating slugs and culminating aggregates.
(6) Despite a dreadful end to last season, culminating in a 6-1 defeat at Stoke City, FSG are pressing ahead with transfer plans agreed with Rodgers, indicating the manager’s position is safe at the moment.
(7) After standardized observation of mating behavior culminating in ejaculation and a sperm plug, females were allowed to produce litters in undisturbed conditions.
(8) As culmination proceeds, pstA cells transform into pstB cells by activating the ecmB gene as they enter the stalk tube.
(9) Significant numbers of PFC were encountered in the spleen as early as 14 to 18 hours after a single intravenous injection of antigen; after 36 hours the number of PFC rose rapidly and culminated in a maximum population at 5 days, followed by a rapid decline and plateau similar to that for circulating antibody.
(10) Richard Betts, a climate expert at the Meteorological Office and one of about 130 senior authors of Friday's report, said: "This is the culmination of three years' work.
(11) It will feature in meetings of the G8 group of industrialised countries, and the Tokyo international conference on African development, culminating in the Brussels meeting on the new deal for fragile states.
(12) At the culmination of each molt, the larval tobacco hornworm exhibits a pre-ecdysis behavior prior to shedding its old cuticle at ecdysis.
(13) This diplomatic battle culminated last year in the signing of a peace agreement between the rebels and the government which imposed an immediate ceasefire, and was supposed to lead to a government of national unity with Machar once again in the vice-president’s office.
(14) Several lines of experimental evidence suggest that an anterior-posterior gradient of cyclic AMP exists in migrating pseudoplasmodia of the cellular slime mold Dictyostelium discoideum, and that this gradient may be responsible for control of the proportions of stalk and spore cells that form during culmination.
(15) The Hanover action was, she says, the culmination of years of protests and training, the result of tactics that have evolved from action to action.
(16) But relations have steadily improved, as did the Vatican’s influence, culminating in last December’s deal with the US.
(17) His comic adventures are too many to relate, but it may be said that they culminate in a café of 'singing waiters' where, after a wealth of comic 'business' with the tray, he shows his disdain for articulate speech by singing a vividly explicit song in gibberish.
(18) Enzyme activity in developing spore cells increased 10-fold during differentiation from myxamoebae (0 h) to the culmination stage (20 h) and decreased slightly at sorocarp (24 h).
(19) In 1993, at the Branch Davidian religious compound outside Waco, Texas, the Bureau of Alcohol, Tobacco and Firearms didn’t wait for the sect leader, David Koresh, to leave before attempting to arrest him and got into a gun battle that claimed 10 victims and led to a disastrous 51-day siege culminating in dozens more deaths.
(20) We propose a model whereby a protein repressor, under the control of PKA, inhibits precocious induction of stalk cell differentiation by DIF and so regulates the choice between slug migration and culmination.