(1) Astrocyte conditioned medium (ACM) enhanced the survival of neurons and the proliferation of astrocytes in embryonic cortical cultures grown in serum-free defined medium.
(2) Race 4 transconjugants containing avrB0 induced a dark brown necrotic HR within 24 h on the soybean cultivars Harosoy and Norchief, whereas race 4 transconjugants containing avrC induced a light brown necrotic HR within 48 h on the soybean cultivars Acme, Peking, Norchief, and Flambeau.
(3) Posterior fossa decompression with obex plugging (the Gardner operation) was the procedure of choice for SM-ACM and for idiopathic holocord syringomyelia.
(4) A variety of protected peptides up to tetradecapeptides have been chromatographed at pressures of 50 to 150 psi and obtained in analytically pure from within 2 to 4 h. With such commonly used protecting groups as N-benzyloxycarbonyl (Z), N-2-(p-biphenylyl)-2-propyloxycarbonyl (Bpoc), N-t-butyloxycarbonyl (Boc), O- and S-t-butyl (But), and S-acetamidomethyl (Acm), compounds were sufficiently soluble in chloroform, alcohols, acetic acid, or mixtures of these solvents for column loading.
(5) Material was fixed in buffered-formalin solution and embedded in metacrylate or Durcupan ACM.
(6) In a phase I-II study, 19 patients with acute lymphoid leukemia (ALL) and 8 patients with non-Hodgkin lymphoma (NHL) were given ACM alone according to the regimen designated treatment 1 described above.
(7) The lack of significant abnormalities in post-ictal polysomnograms corresponds to a functional integrity of the brainstem structures involved in the global organization of sleep and may represent a useful laboratory feature in the diagnosis of ACM.
(8) Proliferation of CFU-acm can be controlled by humoral factors and this allows us to conclude that they are not identical to CFUs and probably belong to the compartment of early hemopoietic cells of the granulocyte series.
(9) Sequential studies of the self-limited HgCl2 GN showed that glomerular PCA, proteinuria and glomerular fibrin deposits peaked concomitantly at the acme of the disease, suggesting that immunologically mediated glomerular damage had triggered the extrinsic coagulation pathway.
(10) The ACMS said the mining industry ads ignored the impacts of industrialisation, which it called “the fastest growing threat to the reef”.
(11) Conversely, the exposure of cells to the anthracycline compounds at 0 degree C resulted in almost complete disappearance of cell kill effects except with ACM; ACM retained substantial cell kill effects even at the given low temperature.
(12) With the MM cells, hyperthermia potentiated the cytotoxic effects of doxorubicin (ADM), daunorubicin, mitoxantrone (DHAD), and quelamycin but did not enhance that of aclacinomycin (ACM).
(13) These data lead us to conclude that ACM-DOX association partly reverses the DOX resistance at clinically achievable concentrations.
(14) The significance of these observations was discussed in terms of possible interactions at the level of ACM and CAF biotransformation and the potential for interactions of CAF with other xenobiotics.
(15) That triumphal speech was his apex, the acme, the zenith of his career.
(16) The therapeutic value of these compounds for established ACME remains uncertain.
(17) The structural basis of this bleeding disorder has been further assessed by studying the interaction of the following Val(12)-substituted human fibrinogen-like peptides with bovine thrombin in aqueous solution by use of two-dimensional NMR spectroscopy (including TRNOE): Ala-Asp-Ser-Gly-Glu-Gly-Asp(7)-Phe-Leu-Ala- Glu-Val(12)-Gly-Gly-Val-Arg(16)-Gly(17)-Pro-Arg-Val-NH2 (F16), Ala-Asp-Ser-Gly-Glu-Gly-Asp(7)-Phe-Leu-Ala-Glu-Val(12)-Gly-Gly-Val- Arg(16) (tF16), Ala-Asp-Ser-Gly-Glu-Cys(Acm)-Asp(7)-Phe-Leu-Ala-Glu-Val(12)-Gly-Gly-Val- Arg(16)-Gly(17)-Pro-Arg-Val-Cys(Acm)-NH2 (F17), and Ala-Asp-Ser-Gly-Glu-Cys(Acm)-Asp(7)-Phe-Leu-Ala-Glu-Val(12)-Gly-Gly- Val-Arg(16) (tF17).
(18) A sensitive enzyme immunoassay method (EIA) for an anticancer drug, aclacinomycin A (ACM), has been developed.
(19) A comparison of the ACM aa sequence with the aa sequences of other proteins in the NBRF data base reveals that ACM has strong similarity to the N-O-diacetylmuramidase secreted by the fungus Chalaropsis.
(20) None of the 8 patients suffering from ovarial cancer benefitted from ACM therapy.
Pinnacle
Definition:
(n.) An architectural member, upright, and generally ending in a small spire, -- used to finish a buttress, to constitute a part in a proportion, as where pinnacles flank a gable or spire, and the like. Pinnacles may be considered primarily as added weight, where it is necessary to resist the thrust of an arch, etc.
(n.) Anything resembling a pinnacle; a lofty peak; a pointed summit.
(v. t.) To build or furnish with a pinnacle or pinnacles.
Example Sentences:
(1) Pinnacle, one of the biggest MPPI providers, blames "wider global financial uncertainty".
(2) For actors of a certain masculine bent, James Bond has long been viewed as a career pinnacle.
(3) The prize for doing that, however, would be the pinnacle of a scientific career.
(4) The takeaway from this pinnacle study is that securing protected areas alone is not enough.
(5) Another said: "The problem with PMQs isn't so much that it's shouty but that the so-called pinnacle of political debate in this country is two men trading petty insults and making nasty jokes about the other while the rest of parliament boos and cheers behind them.
(6) "Winning Wimbledon is the pinnacle of tennis," Murray said afterwards, still in something of a daze a good half hour after the final point.
(7) At the Montenvers railway turn right and zigzag easily up the extra 150m to grab great views of the pinnacles of the Aiguille Verte at 4,122m, Les Drus and the Mer de Glace (sea of ice).
(8) The quarter-final appearances under Sven-Göran Eriksson in two previous World Cups and one European championship in Portugal will now be seen as the pinnacle of their collective achievement.
(9) Suzy Rojtman, of the French national collective for women’s rights, said: “If we have a lot of attackers from the top political class who can harass and assault people unpunished at the pinnacle of the system of political power, think about what others in society are getting away with.” French female journalists are fighting back against sexist politicians | Lénaïg Bredoux Read more Caroline De Haas, a high-profile feminist and former government adviser, said sexual harassment was not unique to France, but in French politics it was happening with a sense of impunity and “an absence of understanding of what violence is to women”.
(10) Our political class is indeed the pinnacle of smug regurgitation.
(11) Parbuckling is a common means of salvaging wrecked vessels, but it has never been used on one of the Concordia's size – the cruise ship is 290 metres (950ft) long – let alone one balancing precariously on two rock pinnacles on a steep slope.
(12) With relatively gentle trail gradients and relentless cliff-top views down to the eroded pinnacles of the lowlands, this is one of Africa's great trekking destinations.
(13) The Heron tower, which stands in Bishopsgate next to Liverpool Street station, has just opened, while several other towers are under development, including the Pinnacle, which is also in Bishopsgate.
(14) The model for this policy is the United States, which represents the pinnacle of private enterprise in the health field.
(15) The spacewalk is the pinnacle of any mission, and something that only a minority of astronauts get to do.
(16) Female chief executives like Ellen Pao may reach the pinnacle in business only to discover that they have risen to the top of a precarious “glass cliff”.
(17) Hodgson is the only man on the FA's shortlist – the body stressed that the meeting on Monday was less an "interview" and more "discussions" over the role – with the former Internazionale, Switzerland and Fulham manager having previously stressed that he perceives the job as "the pinnacle" of his career after previously missing out to Kevin Keegan in 1999 and Sven-Goran Eriksson two years later.
(18) Yet this headline – and the accompanying 6,000-word article attacking debt-fuelled growth – has sparked weeks of speculation over an alleged political feud at the pinnacle of Chinese politics between the president, Xi Jinping, and the prime minister, Li Keqiang, the supposed steward of the Chinese economy .
(19) Pinnacle says its policies offer "peace of mind and reassurance", and adds: "Customers can reduce the level of cover should they want."
(20) Pinnacles has one campsite on the east side of the park, which is more developed than the western entrance.