(n.) An intensely poisonous alkaloid, extracted from aconite.
Example Sentences:
(1) The reduction in 5-HIAA was transient after potassium infusion, but outlasted the infusion of veratridine or aconitine by several hours.
(2) Aconitine potentiated the contractile response of the guinea-pig vas deferens and increased the tissue Na and Ca content.
(3) Tetrodotoxin-sensitive influx of [14C]guanidinium ion was stimulated by aconitine, veratridine, and batrachotoxin with a K0.5 of 7, 5 and 0.3 microM, respectively, the maximal influx being the same with all toxins.
(4) Suppression of aconitine-induced ventricular tachycardia in the dog with various doses of Bunaftine was attempted.
(5) Aconitine will induce arrhythmias after the fiber has been completely repolarized.
(6) Quinidine, but not propranolol, suppressed atrial arrhythmias produced by topical application of aconitine to the atrium, as well as the ventricular arrhythmias that developed approximately 20 hr following coronary artery ligation.
(7) The substance proved to be active in delaying the onset time of aconitine induced arrhythmias in guinea-pig atria.
(8) When aconitine was applied to two epicardial sites in dogs having quinidine-induced QT interval prolongation greater than 10%, torsades de pointes occurred in 80% of instances.
(9) With the former treatment, the off time constant of the charge movement (tau off Q) was unaffected but with aconitine treatment it was considerably increased although it remained smaller than tau off Na.
(10) Furthermore, an attempt is made to present a detailed analysis of permeability changes underlying normal pacemaker activity in Purkinje fibers as compared with the sinus node or with focal activity induced in myocardial fibers by different influences (aconitine, barium ions, stretch, and strong currents).
(11) The appearance of several forms of aconitine-induced arrhythmias was delayed after subacute treatment with carbon disulfide.
(12) The animal experiments revealed that the time of death due to aconitine was significantly delayed in proportion to the dose of TTX compared with the case for aconitine alone, and that the mortality of aconitine was lowered by TTX when the dose ratio of the two toxins was in a particular range.
(13) The nerve compound action potential was inhibited by hypaconitine (5 microM) and aconitine (2-10 microM), as well as by 1 microM tetrodotoxin (TTX).
(14) Atrial arrhythmias were induced in experiments on dogs by electrical stimulation or by local application of aconitine and methacholine to the atrium.
(15) A test for inhibition of mortality induced by intravenous injection of aconitine in rats is proposed as a particularly valid method, owing to its simplicity and degree of specificity, for inclusion among the preliminary screening tests for antiarrhythmic activity.
(16) Both, LG 6-101 and LG 6-102 showed strong antiarrhythmic effects against arrhythmias induced on the fifth day by infusion of aconitine (10 micrograms kg-1 min-1).
(17) When the nerve compound action potential was completely blocked by 2 microM aconitine, the muscle action potential was unaffected, although 1 microM TTX suppressed both potentials to the same degree.
(18) route proved to be more potent and longer-acting than disopyramide, propaphenone and mexiletine against supraventricular and ventricular arrhythmias induced by chloroform, aconitine, ouabain and halothane-adrenaline.
(19) The aim of the experiments was to examine, in vitro, the role of the enteric nervous system in the relationship between motor activity and transmural potential difference (PD) in the guinea pig jejunum and colon using the nerve blocking agents tetrodotoxin (TTX) and aconitine.
(20) Polyphloretinphosphate markedly reduced the improvement of aconitine arrhythmia by PGs, the decrease of the antidysrhythmic effects of arachidonic and linoleic acid was without statistical significance.