(n.) Chronic enlargement of the extremities and face.
Example Sentences:
(1) The changes in cell mass, body fat and extracellular water observed in acromegaly suggest different dose-response relationships between GH and these parameters.
(2) Biochemical evaluation demonstrated characteristic changes typical of acromegaly, and an unusual pattern of delayed somatotropin response to hGHRH40, not previously described in this syndrome.
(3) We have attempted to investigate a relationship between the paradoxical GH secretion with the abnormal glucose tolerance test present in some cases of acromegaly.
(4) Body composition determination by bioelectrical impedance analysis (BIA) has been compared with measurement of total body water (TBW) by tritiated water dilution and estimation of body fat (BF) by measurement of TBW and total body potassium (TBK) in a four-compartment model, in patients with acromegaly.
(5) Thus, lack of response to exogenous GHRH in untreated acromegaly may indicate the presence of an ectopic GHRH producing tumor.
(6) Immunoreactive digoxin-like substance was determined in 52 subjects: 17 healthy ones, 15 patients with essential hypertension, 10 cases of chronic renal failure and 10 patients with acromegaly.
(7) In this situation, insulin binding at low hormone concentrations was further reduced to one-half of that in the control group, and the sensitivity of insulin-induced antilipolysis was markedly decreased in acromegaly.
(8) Ectopic GHRH is a relatively uncommon cause of acromegaly, which should be differentiated from pituitary adenoma, in order to avoid damage to the pituitary gland from unnecessary interventions.
(9) At the pituitary level, it has been shown that the number of binding sites was negatively correlated to growth hormone levels in acromegaly.
(10) We measured 695 sera obtained in short stature children (GH deficiency or normal GH secretory) and adults (normal, hypopituitarism or acromegaly).
(11) Acromegaly is caused by GH-secreting pituitary adenomas and, in rare cases, by ectopic production of GRH with resultant hypersecretion of GH.
(12) We conjecture that postmenopausal and involutional osteoporosis were far advanced before the development of acromegaly, explaining the coexistence of the two conditions.
(13) In conclusion, SMS is a useful clinical tool for treatment of acromegaly, and a multiple sc injection method seems to be preferable.
(14) A patient with acromegaly was shown to have obstructive sleep apnoea by polygraphic recordings.
(15) A young woman presented with acromegaly and amenorrhea-galactorrhea with hypersomatotropinemia and hyperprolactinemia.
(16) The authors report 3 cases of acromegaly diagnosed while the patients were in hospital for cardiovascular disease: arterial hypertension in two and hypertrophic myocardiopathy in all three.
(17) Serum-prolactin concentrations were measured in 111 patients who had radiological abnormalities of the pituitary but no evidence of acromegaly, Cushing's syndrome, or Nelson's syndrome.
(18) There was no difference in diastolic function between patients with active acromegaly and those with treated acromegaly.
(19) The increased risk of colon cancer in acromegaly is consistent with previous clinical reports and suggests opportunities for etiologic research and early cancer detection.
(20) We have observed an apparent hypoglobulinemia in 17 of 35 patients (48.6%) with acromegaly.
Bone
Definition:
(n.) The hard, calcified tissue of the skeleton of vertebrate animals, consisting very largely of calcic carbonate, calcic phosphate, and gelatine; as, blood and bone.
(n.) One of the pieces or parts of an animal skeleton; as, a rib or a thigh bone; a bone of the arm or leg; also, any fragment of bony substance. (pl.) The frame or skeleton of the body.
(n.) Anything made of bone, as a bobbin for weaving bone lace.
(n.) Two or four pieces of bone held between the fingers and struck together to make a kind of music.
(n.) Dice.
(n.) Whalebone; hence, a piece of whalebone or of steel for a corset.
(n.) Fig.: The framework of anything.
(v. t.) To withdraw bones from the flesh of, as in cookery.
(v. t.) To put whalebone into; as, to bone stays.
(v. t.) To fertilize with bone.
(v. t.) To steal; to take possession of.
(v. t.) To sight along an object or set of objects, to see if it or they be level or in line, as in carpentry, masonry, and surveying.
Example Sentences:
(1) It is concluded that during exposure to simulated microgravity early signs of osteoporosis occur in the tibial spongiosa and that changes in the spongy matter of tubular bones and vertebrae are similar and systemic.
(2) In conclusion, the efficacy of free tissue transfer in the treatment of osteomyelitis is geared mainly at enabling the surgeon to perform a wide radical debridement of infected and nonviable soft tissue and bone.
(3) This bone could not be degraded by human monocytes in vitro as well as control bone (only 54% of control; P less than 0.003).
(4) It is suggested that the Japanese may have lower trabecular bone mineral density than Caucasians but may also have a lower threshold for fracture of the vertebrae.
(5) Osteoporosis is characterized by a reduction in bone density.
(6) The half-life of 45Ca in the various calcium fractions of both types of bone was 72 hours in both the control and malnourished groups except the calcium complex portion of the long bone of the control group, which was about 100 hours.
(7) We have addressed the effect of late intensification with autologous bone marrow transplantation on SCLC through a randomized clinical trial.
(8) Our results indicate that increasing the delay for more than 8 days following irradiation and TCD syngeneic BMT leads to a rapid loss of the ability to achieve alloengraftment by non-TCD allogeneic bone marrow.
(9) Decreased MU stops additions of bone by modeling and increases removal of bone next to marrow by remodeling.
(10) Pokeweed mitogen-stimulated rat spleen cells were identified as a reliable source of rat burst-promoting activity (PBA), which permitted development of a reproducible assay for rat bone marrow erythroid burst-forming units (BFU-E).
(11) The fibrous matrix and cartilage formed within the nonunion site transformed to osteoid and bone with increased vascularity.
(12) Periosteal chondroma is an uncommon benign cartilagenous lesion, and its importance lies primarily in its characteristic radiographic and pathologic appearance which should be of assistance in the differential diagnosis of eccentric lesions of bones.
(13) The compressive strength of bone is proportional to the square of the apparent density and to the strain rate raised to the 0.06 power.
(14) Furthermore echography revealed a collateral subperiosteal edema and a moderate thickening of extraocular muscles and bone periostitis, a massive swelling of muscles and bone defects in subperiosteal abscesses as well as encapsulated abscesses of the orbit and a concomitant retrobulbar neuritis in orbital cellulitis.
(15) Survival was independent of the type of clinical presentation and protocol employed but was correlated with the stage (P less than 0.0005), symptoms (P less than 0.025), bulky disease (P less than 0.025) and bone marrow involvement (P less than 0.025).
(16) There was however no difference in the cross-sectional studies and no significant deleterious effect detected of tobacco use on forearm bone mineral content.
(17) During the digestion of these radiolabeled bacteria, murine bone marrow macrophages produced low-molecular-weight substances that coeluted chromatographically with the radioactive cell wall marker.
(18) According to the finite element analysis, the design bases of fixed restorations applied in the teeth accompanied with the absorption of the alveolar bone were preferred.
(19) At consolidation, the distraction area was composed of lamellar trabecular and partly woven bone.
(20) Periodontal disease activity is defined clinically by progressive loss of probing attachment and radiographically by progressive loss of alveolar bone.