(n.) Chronic enlargement of the extremities and face.
Example Sentences:
(1) The changes in cell mass, body fat and extracellular water observed in acromegaly suggest different dose-response relationships between GH and these parameters.
(2) Biochemical evaluation demonstrated characteristic changes typical of acromegaly, and an unusual pattern of delayed somatotropin response to hGHRH40, not previously described in this syndrome.
(3) We have attempted to investigate a relationship between the paradoxical GH secretion with the abnormal glucose tolerance test present in some cases of acromegaly.
(4) Body composition determination by bioelectrical impedance analysis (BIA) has been compared with measurement of total body water (TBW) by tritiated water dilution and estimation of body fat (BF) by measurement of TBW and total body potassium (TBK) in a four-compartment model, in patients with acromegaly.
(5) Thus, lack of response to exogenous GHRH in untreated acromegaly may indicate the presence of an ectopic GHRH producing tumor.
(6) Immunoreactive digoxin-like substance was determined in 52 subjects: 17 healthy ones, 15 patients with essential hypertension, 10 cases of chronic renal failure and 10 patients with acromegaly.
(7) In this situation, insulin binding at low hormone concentrations was further reduced to one-half of that in the control group, and the sensitivity of insulin-induced antilipolysis was markedly decreased in acromegaly.
(8) Ectopic GHRH is a relatively uncommon cause of acromegaly, which should be differentiated from pituitary adenoma, in order to avoid damage to the pituitary gland from unnecessary interventions.
(9) At the pituitary level, it has been shown that the number of binding sites was negatively correlated to growth hormone levels in acromegaly.
(10) We measured 695 sera obtained in short stature children (GH deficiency or normal GH secretory) and adults (normal, hypopituitarism or acromegaly).
(11) Acromegaly is caused by GH-secreting pituitary adenomas and, in rare cases, by ectopic production of GRH with resultant hypersecretion of GH.
(12) We conjecture that postmenopausal and involutional osteoporosis were far advanced before the development of acromegaly, explaining the coexistence of the two conditions.
(13) In conclusion, SMS is a useful clinical tool for treatment of acromegaly, and a multiple sc injection method seems to be preferable.
(14) A patient with acromegaly was shown to have obstructive sleep apnoea by polygraphic recordings.
(15) A young woman presented with acromegaly and amenorrhea-galactorrhea with hypersomatotropinemia and hyperprolactinemia.
(16) The authors report 3 cases of acromegaly diagnosed while the patients were in hospital for cardiovascular disease: arterial hypertension in two and hypertrophic myocardiopathy in all three.
(17) Serum-prolactin concentrations were measured in 111 patients who had radiological abnormalities of the pituitary but no evidence of acromegaly, Cushing's syndrome, or Nelson's syndrome.
(18) There was no difference in diastolic function between patients with active acromegaly and those with treated acromegaly.
(19) The increased risk of colon cancer in acromegaly is consistent with previous clinical reports and suggests opportunities for etiologic research and early cancer detection.
(20) We have observed an apparent hypoglobulinemia in 17 of 35 patients (48.6%) with acromegaly.
Enlargement
Definition:
(n.) The act of increasing in size or bulk, real or apparent; the state of being increased; augmentation; further extension; expansion.
(n.) Expansion or extension, as of the powers of the mind; ennoblement, as of the feelings and character; as, an enlargement of views, of knowledge, of affection.
(n.) A setting at large, or being set at large; release from confinement, servitude, or distress; liberty.
(n.) Diffusiveness of speech or writing; expatiation; a wide range of discourse or argument.
Example Sentences:
(1) In patients with coronary artery disease, electrocardiographic signs of left atrial enlargement (LAE-negative P wave deflection greater than or equal to 1 mm2 in lead V1) are associated with increased left ventricular end diastolic pressure (LVEDP).
(2) In addition to the aqueduct other associated inner ear anomalies have been identified in 60% of this population including: enlarged vestibule (14); enlarged vestibule and lateral semicircular canal (7); enlarged vestibule and hypoplastic cochlea (4); and hypoplastic cochlea (4).
(3) In high concentrations of antiserum, some of the agglutinated cells of L. h. hertigi were enlarged and showed syncytial characters that included up to five nuclei, two dividing nuclei and five basal bodies associated with a single kinetoplast.
(4) During the 20-year period, the number of children with the enlarged thyroid was found to be 1.5-fold as increased.
(5) Patients with MID, but not those with DAT, exhibited correlations between enlargement of the third and lateral ventricles and severity of cognitive impairment.
(6) Electron microscopy revealed a well-developed rough endoplasmic reticulum, an enlarged Golgi apparatus and many highly electron-dense secretory granules resembling those of Clara cells.
(7) Emergency CT showed evidence of pericardial effusion suggesting hemopericardium, enlargement of the ascending aorta and a peripheral semilunar filling defect which caused a slight deformation of the true channel.
(8) Liver enlargement occurred in the intact male with acetophenetidin (1.0%) but not with the N-butyryl- and thiophenol derivatives fed at 1.0 and 0.50%, respectively.
(9) These cells are characterized by enlarged nuclei which are significantly larger than those in MGCs of the Langhans type.
(10) Restriction of feed intake to 40% of normal attenuated the increases in lung weight and lavage protein concentration in MCTP-treated rats and abolished the right ventricular enlargement but did not affect the increased lavage LDH activity.
(11) In chronic active hepatitis and liver cirrhosis, both carbohydrate antigen 19-9 positive biliary ductular cells and factor VIII-related antigen positive endothelial cells were not only observed in the enlarged portal area but also extended into the parenchyma.
(12) The “100% Australian-made” text on packaging has been enlarged to appeal to customer patriotism.
(13) Hyperprolactinemia, hypogonadotropinism, and subnormal plasma testosterone were found in a 65-year-old patient who had an enlarged sella turcica, complained of fatigue, and addmitted to decreased sexual interest and potency.
(14) The observed clinical findings include scarring of the face and hands (83.7%), hyperpigmentation (65%), hypertrichosis (44.8%), pinched facies (40.1%), painless arthritis (70.2%), small hands (66.6%), sensory shading (60.6%), myotonia (37.9%), cogwheeling (41.9%), enlarged thyroid (34.9%), and enlarged liver (4.8%).
(15) Obstetrician-gynecologists must place lymphocytic adenohypophysitis in the differential diagnosis of pituitary enlargement associated with pregnancy, since treatment is available and the sequelae may be life-threatening.
(16) Some of these vacuoles had remnants of mitochondrial cristae or were enlarged endoplasmic reticulum.
(17) In all dosage groups of the 90-day study special histological methods revealed a dose-dependent increase and enlargement of lysosomes in the epithelia of the proximal renal tubules.
(18) The more enlarged lateral ventricles were ipsilateral with the affected visual pathways.
(19) In the transition from proliferating to hypertrophic cell zones in the growth plate, there is an increased in chondrocyte cell volume and a corresponding decrease in collagen content to allow for cell enlargement.
(20) An enlargement of the epidermal proliferative compartment has been noticed.