(n.) Chronic enlargement of the extremities and face.
Example Sentences:
(1) The changes in cell mass, body fat and extracellular water observed in acromegaly suggest different dose-response relationships between GH and these parameters.
(2) Biochemical evaluation demonstrated characteristic changes typical of acromegaly, and an unusual pattern of delayed somatotropin response to hGHRH40, not previously described in this syndrome.
(3) We have attempted to investigate a relationship between the paradoxical GH secretion with the abnormal glucose tolerance test present in some cases of acromegaly.
(4) Body composition determination by bioelectrical impedance analysis (BIA) has been compared with measurement of total body water (TBW) by tritiated water dilution and estimation of body fat (BF) by measurement of TBW and total body potassium (TBK) in a four-compartment model, in patients with acromegaly.
(5) Thus, lack of response to exogenous GHRH in untreated acromegaly may indicate the presence of an ectopic GHRH producing tumor.
(6) Immunoreactive digoxin-like substance was determined in 52 subjects: 17 healthy ones, 15 patients with essential hypertension, 10 cases of chronic renal failure and 10 patients with acromegaly.
(7) In this situation, insulin binding at low hormone concentrations was further reduced to one-half of that in the control group, and the sensitivity of insulin-induced antilipolysis was markedly decreased in acromegaly.
(8) Ectopic GHRH is a relatively uncommon cause of acromegaly, which should be differentiated from pituitary adenoma, in order to avoid damage to the pituitary gland from unnecessary interventions.
(9) At the pituitary level, it has been shown that the number of binding sites was negatively correlated to growth hormone levels in acromegaly.
(10) We measured 695 sera obtained in short stature children (GH deficiency or normal GH secretory) and adults (normal, hypopituitarism or acromegaly).
(11) Acromegaly is caused by GH-secreting pituitary adenomas and, in rare cases, by ectopic production of GRH with resultant hypersecretion of GH.
(12) We conjecture that postmenopausal and involutional osteoporosis were far advanced before the development of acromegaly, explaining the coexistence of the two conditions.
(13) In conclusion, SMS is a useful clinical tool for treatment of acromegaly, and a multiple sc injection method seems to be preferable.
(14) A patient with acromegaly was shown to have obstructive sleep apnoea by polygraphic recordings.
(15) A young woman presented with acromegaly and amenorrhea-galactorrhea with hypersomatotropinemia and hyperprolactinemia.
(16) The authors report 3 cases of acromegaly diagnosed while the patients were in hospital for cardiovascular disease: arterial hypertension in two and hypertrophic myocardiopathy in all three.
(17) Serum-prolactin concentrations were measured in 111 patients who had radiological abnormalities of the pituitary but no evidence of acromegaly, Cushing's syndrome, or Nelson's syndrome.
(18) There was no difference in diastolic function between patients with active acromegaly and those with treated acromegaly.
(19) The increased risk of colon cancer in acromegaly is consistent with previous clinical reports and suggests opportunities for etiologic research and early cancer detection.
(20) We have observed an apparent hypoglobulinemia in 17 of 35 patients (48.6%) with acromegaly.
Gigantism
Definition:
Example Sentences:
(1) It was an artwork that fired the imaginations of 2 million visitors who played with, were provoked by and plunged themselves into the curious atmosphere of The Weather Project , with its swirling mist and gigantic mirrors that covered the hall's ceiling.
(2) Primary thrombocythaemia is to be distinguished from the secondary type by higher counts of megakaryocytes especially of atypic and gigantic forms of these cells, showing up in adequate histological preparations of bone marrow biopsies.
(3) Endless utilitarian apartment blocks and gigantic hotels sprawl seemingly at random in the so-called "coastal cluster".
(4) A case of cerebral gigantism with hydronephrosis in a 20-month-old boy is described.
(5) Meanwhile he is preparing a new double piano concerto by Kevin Volans with the Labèque sisters for a concert at the Edinburgh festival next week, and he tells me with a glint in his eye about ideas for the next two seasons: concert performances of Don Giovanni this October, more Brahms symphonies, and more Berlioz – an ambitious plan to realise the gigantic drama of Roméo and Juliette on a chamber-orchestral scale, following up his rapturously received performances of L'Enfance du Christ in February.
(6) The gigantic lintels that bridge the uprights were also elaborately worked to even their size and height.
(7) Near the entrance was a sprawling camp kitchen, with mountains of supplies, indoor and outdoor facilities and open fires on which some of the cooking was done, and all of the gigantic vats of coffee seemed to be boiled.
(8) But if states cannot trust that their citizens' personal data – as well as sensitive commercial and government information – will not be swept up in a gigantic global surveillance operation, this may be a price they are willing to pay.
(9) However, the most spectacular fundraiser was not the auction room but a wedding, when the ninth duke married the American railroad heiress Consuelo Vanderbilt, securing a gigantic dowry, a fortune in shares and an annual allowance.
(10) This case indicates that the ataxia in cerebral gigantism may be, at least partly, caused by cerebellar atrophy.
(11) An 8-year-old boy with an uncorrected ventricular septal defect, pulmonary stenosis, mental retardation, and gigantism died 24 hours after partial resection of a large right-sided Wilms' tumor.
(12) In Britain business success usually means growth to gigantic and unmanageable size.
(13) This tumor is rare in children and has never, to our knowledge, been recorded in a patient with cerebral gigantism.
(14) Progressive preoperative pneumoperitoneum, combined when necessary with Marlex mesh to obviate tension, enables closure of even gigantic defects.
(15) Simply, Apple is a gigantic company, and iOS in particular is seen as being at a crossroads: Android has overtaken it in sales terms and many critics say it offers users more flexibility – so what's Apple going to do to stop the iPhone looking fusty?
(16) Climate change itself will have a gigantic impact on our economy which will be nothing to do with the carbon bubble.
(17) If we could rediscover that sense of harmony; that sense of being a part of, rather than apart from nature, we would perhaps be less likely to see the world as some sort of gigantic production system, capable of ever-increasing outputs for our benefit – at no cost."
(18) The morphological changes recorded from cells damaged by virus infection included the formation of gigant syncytial cells and intranuclear inclusions of Cowdry Type A.
(19) Spores of both parasites are oviform; those of M. acanthocephali are gigantic, 12-14 micron long and 6-7 micron broad, those of M. propinqui are only 3-4 micron X 1.25-1.50 micron.
(20) Indian media have raised concerns that Beijing may ultimately embark on a gigantic diversion scheme that would channel water away from India to the dry northern plains of China, but such fears are dismissed by Tsering, who says the dam at Metog would be for hydropower, not water diversion.