(1) Although there are no definite data on increased activity with the addition of cyclophosphamide (CTX) and vincristine (VCR) to ADIC, we prefer CYVADIC because of the higher reported complete response rate.
(2) Toxicity due to ADIC treatment was acceptable and did not exceed that seen when doxorubicin was given as a single agent.
(3) It is concluded that serum complement is consumed as part of the multisystem dysfunction, aDIC, and that in conjunction with traditional indicators it may be utilized to gauge the severity of this syndrome.
(4) Complement component C3, component C4, and total hemolytic complement CH50 were measured in blood from ten patients with acute disseminated intravascular coagulation (aDIC) syndromes.
(5) The five dogs having complete responses to the first ADIC treatment had a median survival time of 105 days (range, 45-241 days) after this treatment.
(6) Five of the 15 dogs had a complete response to the first treatment with ADIC, and three had partial responses.
(7) This medium, called GAMA, contains as its relevant constituents the following: the purines guanine and adenine and the purine biosynthetic pathway inhibitors mycophenolic adic, which blocks conversion of adenine ribonucleotides to guanine ribonucleotides, and azaserine, which blocks de novo purine synthesis.
(8) ADIC is apparently a useful chemotherapeutic combination to reinduce remission in some dogs with relapsed lymphoma.
(9) One dog that received a third ADIC treatment no longer responded.
(10) Cardiovascular disease occupy a major place among the adication required to disqualify pilots due to visceral injuries.
(11) The median survival time from the first ADIC treatment for all dogs was 45 days (range, 18-241 days).
(12) Human diploid fibroblast cultures induced to make interferon by the combination of polyriboinosinic acid-polyribocytidylic adic, cycloheximide and actinomycin D degenerate thereafter, owing to the irreversible nature of the inhibition induced by actinomycin D. However, cultures superinduced with the DNA-dependent RNA synthesis inhibitor 5,6-dichloro-I-beta-D-ribofuranosylbenzimadazole (DRB) survive, owing to the reversible nature of the inhibition induced by DRB, and can again be superinduced on several occasions.
(13) The addition of methotrexate did not improve the response rate when compared with our previous CYV ADIC protocol.
(14) Fifteen dogs with relapsed lymphoma were treated with doxorubicin and dacarbazine (ADIC) to reinduce remission.
(15) In combination chemotherapy ADIC and CYVADIC are probably the best choice.