(1) Although there are no definite data on increased activity with the addition of cyclophosphamide (CTX) and vincristine (VCR) to ADIC, we prefer CYVADIC because of the higher reported complete response rate.
(2) Toxicity due to ADIC treatment was acceptable and did not exceed that seen when doxorubicin was given as a single agent.
(3) It is concluded that serum complement is consumed as part of the multisystem dysfunction, aDIC, and that in conjunction with traditional indicators it may be utilized to gauge the severity of this syndrome.
(4) Complement component C3, component C4, and total hemolytic complement CH50 were measured in blood from ten patients with acute disseminated intravascular coagulation (aDIC) syndromes.
(5) The five dogs having complete responses to the first ADIC treatment had a median survival time of 105 days (range, 45-241 days) after this treatment.
(6) Five of the 15 dogs had a complete response to the first treatment with ADIC, and three had partial responses.
(7) This medium, called GAMA, contains as its relevant constituents the following: the purines guanine and adenine and the purine biosynthetic pathway inhibitors mycophenolic adic, which blocks conversion of adenine ribonucleotides to guanine ribonucleotides, and azaserine, which blocks de novo purine synthesis.
(8) ADIC is apparently a useful chemotherapeutic combination to reinduce remission in some dogs with relapsed lymphoma.
(9) One dog that received a third ADIC treatment no longer responded.
(10) Cardiovascular disease occupy a major place among the adication required to disqualify pilots due to visceral injuries.
(11) The median survival time from the first ADIC treatment for all dogs was 45 days (range, 18-241 days).
(12) Human diploid fibroblast cultures induced to make interferon by the combination of polyriboinosinic acid-polyribocytidylic adic, cycloheximide and actinomycin D degenerate thereafter, owing to the irreversible nature of the inhibition induced by actinomycin D. However, cultures superinduced with the DNA-dependent RNA synthesis inhibitor 5,6-dichloro-I-beta-D-ribofuranosylbenzimadazole (DRB) survive, owing to the reversible nature of the inhibition induced by DRB, and can again be superinduced on several occasions.
(13) The addition of methotrexate did not improve the response rate when compared with our previous CYV ADIC protocol.
(14) Fifteen dogs with relapsed lymphoma were treated with doxorubicin and dacarbazine (ADIC) to reinduce remission.
(15) In combination chemotherapy ADIC and CYVADIC are probably the best choice.
Domain
Definition:
(n.) Dominion; empire; authority.
(n.) The territory over which dominion or authority is exerted; the possessions of a sovereign or commonwealth, or the like. Also used figuratively.
(n.) Landed property; estate; especially, the land about the mansion house of a lord, and in his immediate occupancy; demesne.
(n.) Ownership of land; an estate or patrimony which one has in his own right; absolute proprietorship; paramount or sovereign ownership.
Example Sentences:
(1) A former Labour minister, Nicholas Brown, said the public were frightened they "were going to be spied on" and that "illegally obtained" information would find its way to the public domain.
(2) The monoclonal antibody (mAb), SY38, binds to a cytoplasmic domain of synaptophysin.
(3) Therefore, neither of these two regions of the Tat protein appear to be discrete activation domains.
(4) Mapping of the cross-link position between U2 and U6 RNAs is consistent with base-pairing between the 5' domain of U2 and the 3' end of U6 RNA.
(5) A domain containing a CA repeat, similar to ones found in other late, cAMP-induced Dictyostelium genes, is required for cAMP-induced and developmental expression.
(6) Blocking the heparin-binding domains of fibronectin inhibited osteoblast attachment by 40-45%, which is complementary to inhibition results previously obtained with the RGDS tetrapeptide.
(7) The specified region of the inner E2 core domain was highly homologous to the region of the E2 subunit of pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase.
(8) The relevant phase diagram shows different macroheterogeneous phases and microstructured domains.
(9) We have examined the in vitro membrane assembly characteristics of a variety of leader peptidase mutants and found that domains required for insertion in vivo are also necessary for insertion in vitro.
(10) Combination of domain substitutions to generate the [Glu107,123]bFGF and [Arg19,Lys123,126]bFGF mutants did not show any additivity of the mutations on biological activity.
(11) Two lectins, wheat germ agglutinin (WGA) and peanut agglutinin (PNA), were used to compare domains within the interphotoreceptor matrices (IPM) of the cat and monkey, two species where the morphological relationship between the retinal pigment epithelium (RPE) and photoreceptors is distinctly different.
(12) The peptides, which were synthesized using a FMOC solid phase procedure and purified by HPLC, consisted of residues 6-25 from the putative aqueous domain, residues 22-35, which overlaps the putative aqueous and transmembrane domains, and residues 1-38 and 1-40 representing nearly the full length of beta-AP.
(13) The region is distinctive in that the sequence is absent from the homologous domain of the erythroid alpha chain and diverges from the normal internal repeat structure observed throughout other spectrins.
(14) Synthetic DNA corresponding to the hydrophobic domain of cytochrome b5 was enzymatically fused in-frame to cloned DNA corresponding to the C-terminus of the Escherichia coli enzyme, beta-galactosidase.
(15) In this paper the domain of validity of the unlabelled and labelled minimal models of glucose disappearance is studied.
(16) In vivo labeling with 32Pi showed that plectin was the target for cAMP-independent protein kinases which phosphorylated 18-kDa domains at the end(s) of the molecule.
(17) In contrast, the enzymic domain of the colicin (T2) remained in the aqueous phase and was recovered in a highly active form as a consequence of its dissociation from the immunity protein.
(18) The most striking homology was to yeast SEC7 in the central domain of the gene (57% identical over 466 bp) and also the protein level (42% identical amino acids; 39% conserved amino acids).
(19) Its features are consistent with observed structural dimensions and the molecular periodicities related to transcription, replication and matrix attachment domains.
(20) The three major RNA domains, as defined by secondary structure, appear to exist as autonomous structural units in three dimensions, for the most part.