What's the difference between administer and underdose?
Administer
Definition:
(v. t.) To manage or conduct, as public affairs; to direct or superintend the execution, application, or conduct of; as, to administer the government or the state.
(v. t.) To dispense; to serve out; to supply; execute; as, to administer relief, to administer the sacrament.
(v. t.) To apply, as medicine or a remedy; to give, as a dose or something beneficial or suitable. Extended to a blow, a reproof, etc.
(v. t.) To tender, as an oath.
(v. t.) To settle, as the estate of one who dies without a will, or whose will fails of an executor.
(v. i.) To contribute; to bring aid or supplies; to conduce; to minister.
(v. i.) To perform the office of administrator; to act officially; as, A administers upon the estate of B.
(n.) Administrator.
Example Sentences:
(1) However, there was no correlation between the length of time PN was administered to onset of cholestasis and the gestational age or birth weight of the infants.
(2) A quantitative comparison of tissue distribution and excretion of an orally administered sublethal dose of [3H]diacetoxyscirpenol (anguidine) was made in rats and mice 90 min, 24 hr, and 7 days after treatment.
(3) A novel prostaglandin E2 analogue, CL 115347, can be administered transdermally on a long-term basis.
(4) We investigated whether these peptides also affect the sleep EEG in humans when given intravenously by comparing polysomnographically the effects of four boluses of (1) placebo, (2) 50 micrograms GHRH or (3) 50 micrograms SRIF administered at 22.00, 23.00, 24.00 and 1.00 h to 7 male controls.
(5) Veterans admitted to a 90-day alcoholism treatment program were administered the MMPI, and those who completed the program were retested before discharge.
(6) To the remaining patients who suffered from severe insomnia, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (chlordesmethyldiazepam, 2 mg orally) was administered for 7 consecutive evenings.
(7) The second experiments entailed use of the nonspecific opiate antagonist, naloxone, as well as the specific delta antagonist, ICI 154,129, against seizures induced by icv-administered morphine, morphiceptin, DADL, or DSLET.
(8) Pentamidine aerosol was administered with an MA2 jet nebulizer.
(9) testosterone, fentanyl, nicotine) may ultimately be administered in this way, important questions pertaining to pharmacology (tolerance), toxicity (irritation, sensitisation) and dose sufficiency (penetration enhancement) remain.
(10) Blood was cross-matched preoperatively in 47.7% of patients and 90% of this blood was either not administered or given as a delayed nonurgent procedure.
(11) We are currently conducting a trial to compare the ability of DHPG administered plus an anti-CMV immune globulin preparation with acyclovir to prevent posttransplant TI-CMV disease.
(12) Buserelin and Flutamide were administered three times daily, intranasally and orally respectively, at a dose of 1.2 mg and 750 mg for twelve months.
(13) Infusion of 1 unit of 25-HCC per hour for 6 hours induced an antiphosphaturia only when administered with 0.2 units of PTH per hour, while neither agent alone changed phosphate excretion.
(14) But no such protective effect is seen if the phenobarbitone is administered after treatment with these carcinogens.
(15) Mechanical ventilation was soon instituted and several antibiotics and acyclovir were administered intravenously, with marked effects.
(16) The effect of ipratropium bromide administered at two dosage levels, 40 and 80 mug, isoproterenol, 150 mug, and placebo using a metered dose inhaler was evaluated in ten adult patients with asthma in a double-blind, crossover study.
(17) In one series of experiments, the animals were not treated before the tissues were conventionally fixed; in another, anesthetized animals were administered horseradish peroxidase 20 min before the tissues were fixed.
(18) This was treated with local radiation therapy consisting of 2700 rads administered in 15 fractions during a period of 28 days.
(19) Efficacy and tolerability of perorally administered desmopressin were evaluated in 12 adult patients suffering from central diabetes insipidus.
(20) The relatively high incidence of nephroblastoma in the Nb rat using transplacentally administered ENU appears to represent a suitable basis for developing a rodent model of human nephroblastoma or Wilms' tumor.
Underdose
Definition:
(n.) A dose which is less than required; a small or insufficient dose.
(v. t. & i.) To give an underdose or underdoses to; to practice giving insufficient doses.
Example Sentences:
(1) In renal failure patients, there is obviously not only the risk of overdosing and toxic side effects but also the risk of insufficient bactericidal effect as a result of underdosing.
(2) Eleven other lions, nine of which were initially underdosed, required additional injections of the drug combination for safe handling.
(3) Using the models of simulated air cavities, combined air cavity and air channel, and taking measurement with a small window parallel plate ionization chamber in solid phantoms, it is found that the air spaces in the human body will cause underdose or overdose at the exit air space surface for 10MV X-ray and Co-60 r-ray.
(4) As there was no evidence that higher mianserin (plus metabolite) steady-state concentrations were associated with a more favourable effect, the negative outcome appeared not to be related to underdosing with mianserin.
(5) Underdosed mass drug administration and subcurative medication have this direct effect.
(6) Variability in V was not significantly different than variability in CL, and may result in severe underdosing or overdosing.
(7) An average of 22% of the target volume was underdosed at the 95% isodose level with the 2D plans compared to 7% with the 3D plans.
(8) However, mid-plane planning was shown to be totally inadequate for off-axis planes, where the average target gradient and underdose scores were reduced by 10 units.
(9) An explanation for the observed underdose is also presented.
(10) These data indicate that etoposide bioavailability is not constant and oral therapy may lead to unsuspected underdosing or unexpected toxicity in schedules extending over several days.
(11) However, tumors growing on the surface of the air cavities do cause serious concern by conscientious radiation therapists and physicist about the possibility of underdose.
(12) (2) Caution is advisable when a transplant team adopts a new cyclosporine assay for clinical use; formal study between existing assay methods and any newly adopted assay is warranted to prevent inadvertent underdosing or overdosing with cyclosporine.
(13) In 50% of new diagnoses medication was underdosed, in some cases medication was wrong or not broad enough.
(14) In conclusion, these data caution about the risk of underdosing 6-mercaptopurine in overweight children when administering it on the basis of body surface area.
(15) Serum TSH mainly prevents the underdose of patients but cannot help in case of overdose.
(16) The upper neck nodes may be underdosed since this is 20% cooler than the lateral-anterior neck dose (where a large 120% hot spot exists).
(17) As changes in pharmacokinetic parameters will alter dosage requirements, dosage regimens cannot be transferred from one age group to another without the risk of underdosing or overdosing.
(18) As a result, unanticipated underdosing inside the field and greater dose outside the field can occur when high-energy X rays are used.
(19) He cautioned of the impending crisis while accepting his Nobel prize in 1945 : “There is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant.” But scientific innovation, and increased awareness, has shown the severity of the threat.
(20) It is concluded that, usually from unjustified fear of exceeding the "tolerance limit", radiotherapy of glioblastomas is underdosed.