(a.) In the front or before others, as regards progress or ideas; as, advanced opinions, advanced thinkers.
(a.) Far on in life or time.
Example Sentences:
(1) This selective review emphasizes advances in neurochemistry which provide a context for current and future research on neurological and psychiatric disorders encountered in clinical practice.
(2) Increased plasmin activity was associated with advancing stage of lactation and older cows after appropriate adjustments were made for the effects of milk yield and SCC.
(3) These results suggest that the pelvic floor is affected by progressive denervation but descent during straining tends to decrease with advancing age.
(4) An association of cyclophosphamide, fluorouracil and methotrexate already employed with success against solid tumours in other sites was used in the treatment of 62 patients with advanced tumours of the head and neck.
(5) When TSLP was pretreated with TF5 in vitro, the most restorative effects on the decreased MLR were found in hyperplastic stage and the effects were becoming less with the advance of tumor developments.
(6) Finally the advanced automation of the equipment allowed weekly the evaluation of catecholamines and the whole range of their known metabolites in 36 urine samples.
(7) Since the advance and return of sperm inside the tubes could facilitate the interaction of sperm with secretions participating in its maturation, the persistent infertility after vasectomy could be related to the contractile alteration that follows the excessive tubal distention.
(8) Over the past decade the use of monoclonal antibodies has greatly advanced our knowledge of the biological properties and heterogeneity that exist within human tumours, and in particular in lung cancer.
(9) The automatic half of both the motor which advances the trepan as well as the second motor which rotates the trepan is triggered by the sudden change in electrical resistance between the trepan and the patient's internal body fluid, at the final stage of penetration.
(10) Under a revised deal most people are now being vetted on time, but charges for the service have had to rise from £12 and free vetting for volunteers, to £28 for a standard disclosure and £33 for an advanced disclosure.
(11) Histological and electron-microscopic study of the lungs of 15 patients who had been treated with bleomycin for advanced squamous cell carcinoma demonstrated marked histological changes in nine.
(12) With better understanding of metabolic and compositional requirements, great advances have been made in the area of total parenteral nutrition.
(13) Meanwhile Ed Miliband, the Labour leader, waiting anxiously for news of the scale of the Labour advance in his first nationwide electoral test, will urge the electorate not to be duped by the promise of a coalition mark 2, predicting sham concessions by the Conservatives .
(14) 16 tube (usually a Baker tube) was inserted by gastrostomy and advanced distally into the colon.
(15) Of his number, 266 patients were in the advance stage of their disease while another 42 still had localized cancers.
(16) N-Acetyl-beta-D-glucosaminidase (GAD) activities did not change significantly duringlate fetal, neonatal or young adult stages but increased significantly with advancing age.
(17) Serial antepartum platelet alloantibody quantitation by an enzyme-linked immunoabsorbent assay revealed rising antibody titers during advancing gestation.
(18) Most of the progressive cases were alcoholic, and some showed progression to advanced pancreatitis within 4 years.
(19) Expansion of the cell sheet following attachment, and the fusion of epiblasts advancing toward each other, does not require the presence of mineralocorticoid.
(20) One hundred and sixteen patients with advanced and metastatic adenocarcinoma of the pancreas were randomized to treatment with combined Streptozotocin and 5-fluorouracil or combined Streptozotocin and cyclophosphamide.
Broad
Definition:
(superl.) Wide; extend in breadth, or from side to side; -- opposed to narrow; as, a broad street, a broad table; an inch broad.
(superl.) Extending far and wide; extensive; vast; as, the broad expanse of ocean.
(superl.) Extended, in the sense of diffused; open; clear; full.
(superl.) Fig.: Having a large measure of any thing or quality; not limited; not restrained; -- applied to any subject, and retaining the literal idea more or less clearly, the precise meaning depending largely on the substantive.
(superl.) Comprehensive; liberal; enlarged.
(superl.) Plain; evident; as, a broad hint.
(superl.) Free; unrestrained; unconfined.
(superl.) Characterized by breadth. See Breadth.
(superl.) Cross; coarse; indelicate; as, a broad compliment; a broad joke; broad humor.
(superl.) Strongly marked; as, a broad Scotch accent.
(n.) The broad part of anything; as, the broad of an oar.
(n.) The spread of a river into a sheet of water; a flooded fen.
(n.) A lathe tool for turning down the insides and bottoms of cylinders.
Example Sentences:
(1) As a group, the three mammalian proteins resemble bovine serum conglutinin and behave as lectins with rather broad sugar specificities directed at certain non-reducing terminal N-acetylglucosamine, mannose, glucose and fucose residues, but with subtle differences in fine specificities.
(2) Their receptive fields comprise a temporally and spatially linear mechanism (center plus antagonistic surround) that responds to relatively low spatial frequency stimuli, and a temporally nonlinear mechanism, coextensive with the linear mechanism, that--though broad in extent--responds best to high spatial-frequency stimuli.
(3) Faisal Abu Shahla, a senior official in Fatah, an organisation responsible for a good deal of repression of its own when it was in power, accuses Hamas of holding 700 political prisoners in Gaza as part of a broad campaign to suppress dissent.
(4) Accordingly, when bFGF, complexed to heparin, is treated with pepsin A, an aspartic protease with a broad specificity, only the Leu9-Pro10 peptide bond is cleaved generating the 146-amino acid form.
(5) A broad specificity of LipDH was observed for the glycine cleavage system.
(6) Time-resolved tyrosine fluorescence anisotropy shows global correlation times broadly in agreement with the NMR results, but with an additional faster correlation time [approximately 600 ps].
(7) Cefuzoname seems to be among the middle ranks of beta-lactam agents as far as penetration rate is concerned; however, when its potent antibacterial activity and broad spectrum are taken into account, the concentrations in CSF in patients with meningitis seem worth examining.
(8) It was possible to classify the bacteriophages broadly, according to the variety of mutants that were resistant to them.
(9) The surface film transition is especially noted in the pressure-area curve of the surfactant and approximates in two dimensions the broad thermotropic phase transition of the bulk phase surfactant.
(10) If Clegg's concerns do broadly accord with Cameron's, how will the PM sell such a big U-turn to his increasingly anti-Clegg backbenchers?
(11) Federal endorsement of the HMO concept has resulted in broad understanding of a number of concepts unknown in fee-for-service medicine.
(12) Broad-based secular comprehensives that draw in families across the class, faith and ethnic spectrum, entirely free of private control, could hold a new appeal.
(13) A library of Zymomonas mobilis genomic DNA was constructed in the broad-host-range cosmid pLAFR1.
(14) Amphotericin B has a broad spectrum of action that includes most of the major fungal pathogens of man.
(15) All other broad-spectrum benzimidazole anthelmintics, regardless of substituent at the 2 position (methyl carbamate or thiazolyl group), are flat.
(16) As Kuwait is one of the countries where the total consumption of antibiotics is very high as compared to most of the western countries, we are inclined to assume that this generous policy for the prescription of especially ampicillin and other broad spectrum antibiotics in uncomplicated infections has generated this serious consequence.
(17) Learning to do this well involves acquiring a broad base of knowledge and a complex range of skills.
(18) The narrow latency window contained significantly more responses than could be explained by the spontaneous activity rate, but this was not true for the added time permitted by the broad window.
(19) Taxol has been demonstrated in numerous laboratories worldwide to have broad-spectrum antitumor activity against many tumor models.
(20) This strain of the organism fits a pattern of susceptibility that is rare among N asteroides isolates in general and has been called the type 5 pattern, described as a resistance to broad spectrum cephalosporins, ciprofloxacin, and all aminoglycosides except amikacin.