(a.) In the front or before others, as regards progress or ideas; as, advanced opinions, advanced thinkers.
(a.) Far on in life or time.
Example Sentences:
(1) This selective review emphasizes advances in neurochemistry which provide a context for current and future research on neurological and psychiatric disorders encountered in clinical practice.
(2) Increased plasmin activity was associated with advancing stage of lactation and older cows after appropriate adjustments were made for the effects of milk yield and SCC.
(3) These results suggest that the pelvic floor is affected by progressive denervation but descent during straining tends to decrease with advancing age.
(4) An association of cyclophosphamide, fluorouracil and methotrexate already employed with success against solid tumours in other sites was used in the treatment of 62 patients with advanced tumours of the head and neck.
(5) When TSLP was pretreated with TF5 in vitro, the most restorative effects on the decreased MLR were found in hyperplastic stage and the effects were becoming less with the advance of tumor developments.
(6) Finally the advanced automation of the equipment allowed weekly the evaluation of catecholamines and the whole range of their known metabolites in 36 urine samples.
(7) Since the advance and return of sperm inside the tubes could facilitate the interaction of sperm with secretions participating in its maturation, the persistent infertility after vasectomy could be related to the contractile alteration that follows the excessive tubal distention.
(8) Over the past decade the use of monoclonal antibodies has greatly advanced our knowledge of the biological properties and heterogeneity that exist within human tumours, and in particular in lung cancer.
(9) The automatic half of both the motor which advances the trepan as well as the second motor which rotates the trepan is triggered by the sudden change in electrical resistance between the trepan and the patient's internal body fluid, at the final stage of penetration.
(10) Under a revised deal most people are now being vetted on time, but charges for the service have had to rise from £12 and free vetting for volunteers, to £28 for a standard disclosure and £33 for an advanced disclosure.
(11) Histological and electron-microscopic study of the lungs of 15 patients who had been treated with bleomycin for advanced squamous cell carcinoma demonstrated marked histological changes in nine.
(12) With better understanding of metabolic and compositional requirements, great advances have been made in the area of total parenteral nutrition.
(13) Meanwhile Ed Miliband, the Labour leader, waiting anxiously for news of the scale of the Labour advance in his first nationwide electoral test, will urge the electorate not to be duped by the promise of a coalition mark 2, predicting sham concessions by the Conservatives .
(14) 16 tube (usually a Baker tube) was inserted by gastrostomy and advanced distally into the colon.
(15) Of his number, 266 patients were in the advance stage of their disease while another 42 still had localized cancers.
(16) N-Acetyl-beta-D-glucosaminidase (GAD) activities did not change significantly duringlate fetal, neonatal or young adult stages but increased significantly with advancing age.
(17) Serial antepartum platelet alloantibody quantitation by an enzyme-linked immunoabsorbent assay revealed rising antibody titers during advancing gestation.
(18) Most of the progressive cases were alcoholic, and some showed progression to advanced pancreatitis within 4 years.
(19) Expansion of the cell sheet following attachment, and the fusion of epiblasts advancing toward each other, does not require the presence of mineralocorticoid.
(20) One hundred and sixteen patients with advanced and metastatic adenocarcinoma of the pancreas were randomized to treatment with combined Streptozotocin and 5-fluorouracil or combined Streptozotocin and cyclophosphamide.
Primitive
Definition:
(a.) Of or pertaining to the beginning or origin, or to early times; original; primordial; primeval; first; as, primitive innocence; the primitive church.
(a.) Of or pertaining to a former time; old-fashioned; characterized by simplicity; as, a primitive style of dress.
(a.) Original; primary; radical; not derived; as, primitive verb in grammar.
(n.) An original or primary word; a word not derived from another; -- opposed to derivative.
Example Sentences:
(1) Cloacal exstrophy, centered on the maldevelopment of the primitive streak mesoderm and cloacal membrane, results in bladder and intestinal exstrophy, omphalocele, gender confusion, and hindgut deformity.
(2) Evx-1 RNA is first detected shortly before the onset of gastrulation in a region of ectoderm containing cells that will soon be found in the primitive streak.
(3) As an extension of the previous study which indicated that mesoglea is a primitive basement membrane which has retained some characteristics of interstitial extracellular matrix, the present study was undertaken to analyze the role of mesoglea components during head regeneration in Hydra vulgaris.
(4) neuroblastomas, primitive neuroectodermal tumours (PNETs), rhabdomyosarcomas and malignant lymphomas.
(5) We concluded that the primitive eukaryote D.discoideum contains proteins which show functional and physical similarity with the alpha-subunits of vertebrate G-proteins.
(6) Mechanisms are suggested whereby rudimentary appetitive programs already encoded along facing dendrite membrane pairs within the specialized intrafascicular milieu, may trigger and control nipple search and suckling in the still blind and only primitively mobile neonate.
(7) Thus, the progeny of infected primitive multipotential cells are competent to express integrated proviruses.
(8) Multiple tuberculomas have simulated either an alcoolic encephalopathy in one case or a primitive cerebral tumour in another one.
(9) This increased cell flow down the early stages of the red cell pathway in CML suggests that heightened proliferation and differentiation of primitive hemopoietic cells may be a more general phenomenon than previously suspected in this disease.
(10) The Lerner & Lerner Scale for assessing primitive defenses is reviewed.
(11) Only tumors of astrocytic lineage like astrocytomas and glioblastomas, or tumors of mixed lineage as oligo-astrocytomas and multipotential primitive neuroectodermal tumors (PNET) expressed TNF-alpha-like immunoreactivity.
(12) This epithelial cell was tentatively identified as primitive extraembryonic endoderm by its ultrastructural appearance and its possession of cytokeratin intermediate filaments.
(13) The long-term culture corresponded to mouse MXT and MCF-7 cell lines whereas the primary culture corresponded to primitive breast cancers squashed onto histologic slides and maintained in cultures for between 12 and 48 h. Cell proliferation was evaluated by means of digital cell image analysis of Feulgen-stained nuclei.
(14) From these facts, it was concluded that the follicular, as well as acanthomatous, ameloblastoma is liable to undergo squamous differentiation, whereas the plexiform ameloblastoma remains in primitive stage of tumor differentiation.
(15) A cluster of spermatogonia may be derived from one primitive germ cell and it develops round a "Sertoli" cell.
(16) Shielded marrow self renewal capacity, a measurement reflecting primitive hematopoietic stem cell function, remained depressed and did not recover with time.
(17) In a 3-year-old child, a rare combination of a Dandy-Walker syndrome, a primitive trigeminal artery and a facial haemangioma was found.
(18) As the histochemical and ultrastructural findings are non specific, we believe, according to recent opinions, that this tumor could originate in a very primitive cell, able to differentiate to endocrine or exocrine elements, almost always incompletely.
(19) It is likely that the development of these malignancies is an expression of the multipotential nature of primitive germ cells.
(20) Morphology of the mature spermatozoon is modified from that of the classic primitive or ect-aquasperm type by having 1) the acrosome embedded in the nucleus (the only known example within the Mollusca), 2) a deep basal invagination in the nucleus containing proximal and distal centrioles and an enveloping matrix (derived from the rootlet), 3) laterally displaced periaxonemal mitochondria, and 4) a tail extending from the basal invagination of the nucleus.