(1) The low affinity of several N1-alkylpyrroleethylamines suggests that the benzene portion of the alpha-methyltryptamines is necessary for significant affinity.
(2) These results demonstrate that increased availability of galactose, a high-affinity substrate for the enzyme, leads to increased aldose reductase messenger RNA, which suggests a role for aldose reductase in sugar metabolism in the lens.
(3) It has been generally believed that the ligand-binding of steroid hormone receptors triggers an allosteric change in receptor structure, manifested by an increased affinity of the receptor for DNA in vitro and nuclear target elements in vivo, as monitored by nuclear translocation.
(4) Because cystine in medium was converted rapidly to cysteine and cysteinyl-NAC in the presence of NAC and given that cysteine has a higher affinity for uptake by EC than cystine, we conclude that the enhanced uptake of radioactivity was in the form of cysteine and at least part of the stimulatory effect of NAC on EC glutathione was due to a formation of cysteine by a mixed disulfide reaction of NAC with cystine similar to that previously reported for Chinese hamster ovarian cells (R. D. Issels et al.
(5) We sought additional evidence for an inverse relationship between functional CTL-target cell affinity on the one hand, and susceptibility of the CTL-mediated killing to inhibition by alpha LFA-1 and alpha Lyt-2,3 monoclonal antibodies on the other hand.
(6) This theory was confirmed by product analysis and by measuring the affinity of the substrate for the enzyme by its inhibition of p-nitrophenyl glucoside hydrolysis.
(7) We report a series of experiments designed to determine if agents and conditions that have been reported to alter sodium reabsorption, Na-K-ATPase activity or cellular structure in the rat distal nephron might also regulate the density or affinity of binding of 3H-metolazone to the putative thiazide receptor in the distal nephron.
(8) ASF-II was purified to apparent homogeneity by using concanavalin A-agarose affinity chromatography, DEAE-cellulose chromatography, alumina gel adsorption, and isoelectric focussing techniques.
(9) The occupation of the high affinity calcium binding site by Ca(II) and Mn(II) does not influence the Cu(II) binding process, suggesting that there is no direct interaction between this site and the Cu(II) binding sites.
(10) Radioligand binding studies revealed the presence of a single class of high-affinity (Kd = 2-6 X 10(-10) M) binding sites for ET-1 in both cells, although the maximal binding capacity of cardiac receptor was about 6- to 12-fold greater than that of vascular receptor.
(11) The penicillin-resistant Enterococcus hirae R40 has a typical profile of membrane-bound penicillin-binding proteins (PBPs) except that the 71 kDa PBP5 of low penicillin affinity represents about 50% of all the PBPs present.
(12) The enzyme was solubilized by Triton X-100 and purified approximately 480-fold by gel filtration and affinity chromatography on alanine methyl ketone-AH-Sepharose 4B.
(13) Only estrogenic hormones are bound with high affinity.
(14) These results indicate that both the renal brush-border and basolateral membranes possess the Na(+)-dependent dicarboxylate transport system with very similar properties but with different substrate affinity and transport capacity.
(15) This novel mechanism of receptor regulation, named transmodulation, should be distinguished from the reduction in total receptor number caused by the homologous ligand (downregulation) and from the change in affinity produced by the binding of agonists or antagonists to the same receptor site.
(16) Neurotensin (NT) is an endogenous brain tridecapeptide for which high affinity binding sites exist in the central nervous system.
(17) In lactate medium the capacity of each AIB carrier is unchanged but its affinity is reduced to one-third.
(18) The telencephalon of teleost fish shows high affinity uptake for D-[3H]aspartate, intermediate levels of GABAergic markers and low levels of cholinergic enzymes.
(19) In all immunized rabbits the antisera obtained with the 7 alpha-derivative had a higher affinity and a narrower specificity than the antiserum obtained with the 7 beta-derivative.
(20) The binding parameters indicate that the principal activating effect of UMP is not simply to increase the affinity of the enzyme for glucose.
Breton
Definition:
(a.) Of or relating to Brittany, or Bretagne, in France.
(n.) A native or inhabitant of Brittany, or Bretagne, in France; also, the ancient language of Brittany; Armorican.
Example Sentences:
(1) They may not be Kurds or Kosovans, but they have much in common with Basques, Bretons and Catalans.
(2) He dismisses as "recycling" a pact announced by the prime minister, Jean-Marc Ayrault – a former Breton mayor – last month to defuse the red caps' protests, providing for €2m of investment in the region.
(3) When Claudie Le Bail joined tens of thousands of Breton "red cap" demonstrators protesting in Carhaix at the end of November to oppose regional job losses and a green tax on road freight, she took her 79-year-old mother with her.
(4) The area is part of a chain of uninhabited barrier islands in the Breton national wildlife refuge.
(5) By 6 May oil was reported as reaching the Chandeleur Islands off the Louisiana and Freemason Island in the Breton national wildlife refuge .
(6) Tips: Hook a mackerel and fry it for dinner just off the Cabot Trail, and learn to make Acadian potato pancakes for $22pp while savouring the cultural lore of Cape Breton.
(7) It has been highly commended in the Michelin guide and serves Breton food with a strong seafood theme.
(8) An epidemic of hepatitis B occurring in 1988 and 1989 in Cape Breton brought to light the existence of a group of "buddies" who engaged in injection drug use.
(9) 187, 227-232; Mäntele, W., Wollenweber, A., Nabedryk, E., & Breton, J.
(10) The pairing of owners Stephen Toman in the kitchen and Breton Alain Kerloc'h out front brings a superb balance of fine dining on the plate, with a fist-pumpingly rocking atmosphere.
(11) Seafood stalls are loaded with locally caught fish and fruits de mer , and look out for the excellent Breton oysters.
(12) At the foot of the hill lies the contemporary tide line of sex-sleaze – the surrealist André Breton once called it "diamantiferous mud", but nowadays it is all mud and any diamonds are paste.
(13) Earlier this year, a radio announcer in Canada set up a website inviting Americans to move to Cape Breton, population 100,000, should Trump win.
(14) She’s a locavore (where possible, she eats locally produced food) and has been recycling since the 80s, a habit learned from her Breton grandmother.
(15) Concentrations of progesterone and oestrogens were determined by radioimmunoassay in the peripheral blood of 22 Percheron and Breton breed mares from the 6th day of oestrus to the 150th day of pregnancy.
(16) This latter result is in agreement with previous photoselection studies on the same bacterial species (Vermeglio, A., Breton, J., Paillotin, G. and Cogdell, R. (1978) Biochim.
(17) The close linkage between the disease locus and several DNA markers allowed a study of the DNA restriction polymorphism pattern in 30 Breton families.
(18) But his main focus now is preparing for the second act of the revolt with a big congress in March which will formally take up Breton grievances.
(19) We have previously described a monoclonal antibody (FA6-152), obtained by immunizing mice with fetal human erythrocytes [Edelman, Vinci, Villeval, Vainchenker, Henri, Miglierina, Rouger, Reviron, Breton-Gorius, Sureau & Edelman (1986) Blood 67, 56-63].
(20) Delicious crepes and galettes , and Breton cider, are found on other stalls.