(v. t.) To bring together; to collect into a mass or sum. "The aggregated soil."
(v. t.) To add or unite, as, a person, to an association.
(v. t.) To amount in the aggregate to; as, ten loads, aggregating five hundred bushels.
(a.) Formed by a collection of particulars into a whole mass or sum; collective.
(a.) Formed into clusters or groups of lobules; as, aggregate glands.
(a.) Composed of several florets within a common involucre, as in the daisy; or of several carpels formed from one flower, as in the raspberry.
(a.) Having the several component parts adherent to each other only to such a degree as to be separable by mechanical means.
(a.) United into a common organized mass; -- said of certain compound animals.
(n.) A mass, assemblage, or sum of particulars; as, a house is an aggregate of stone, brick, timber, etc.
(n.) A mass formed by the union of homogeneous particles; -- in distinction from a compound, formed by the union of heterogeneous particles.
Example Sentences:
(1) Aggregation was more frequent in low-osmolal media: mainly rouleaux were formed in ioxaglate but irregular aggregates in non-ionic media.
(2) We have examined overlapping octapeptides from the kappa IIIb light chain variable region and show that some framework peptides have the ability to bind aggregated IgG.
(3) Platelet-rich plasma (PRP) was prepared, and platelet aggregation studies were conducted directly or conducted on washed platelets prepared from PRP collected with ACD.
(4) Macrophages internalize aggregated low density lipoprotein (LDL) by LDL receptor-dependent phagocytosis.
(5) Cicaprost is an orally available analogue of PGI2 and has been shown to inhibit platelet aggregation in both in vitro and animal studies.
(6) Only IgG2a and IgG2b myeloma proteins bound readily to IC-21 Fc-receptors, the former in nonaggregated as well as aggregated form, the latter only as aggregated complexes.
(7) When the aggregates occurred on the cell periphery their position coincided with areas free of lamellae.
(8) 2-(4'-Isobutylphenyl)propionic acid, ibuprofen, is an antiinflammatory agent which possesses moderate platelet aggregation inhibitory activity.
(9) In addition, spontaneous platelet aggregation is increased when vegetations are present on cardiac valves.
(10) At concentrations several hundredfold higher than the equivalents present in the minimum concentration of rat skin soluble collagen required for platelet aggregation, neither Hyl-Gal (at 29 muM) nor Hyl-Gal-Glc (at 18 muM) caused platelet aggregation or inhibited platelet aggregation by native collagen.
(11) The mechanisms leading to spontaneous platelet aggregation and thrombocytopenia appear to be similar to those described for other patients with type IIB vWD.
(12) There is approximately a 25% decrease in aggregation from regions of the rib distal to the metaphyseal-growth plate junction (69%) to the region proximal to it (50%).
(13) Laboratory data were aggregated similarly within each study, using the last active drug as a grouping factor.
(14) No correlation could be found between DS content and state of aggregation.
(15) The synthetic S-nitroso-thiol, S-nitroso-N-acetylcysteine, markedly inhibited platelet aggregation with an IC50 of 6 nM.
(16) On the other hand, ultraviolet (320-nm) light, absorbed by 3-hydroxy-pyridinium cross-links which were rapidly photolyzed, partially dissociated polymeric collagen aggregates from bovine Achilles tendon after subsequent heating.
(17) The ternary complex consisting of a 65-kDa peptide originating from the proteoglycan core protein and a 43-kDa link protein bound to hyaluronic acid was purified from a clostripain digest of the rat chondrosarcoma aggregating proteoglycan and 14C-carbamylated with potassium [14C]cyanate.
(18) The IC50 on arachidonic acid-induced platelet aggregation was: fisetin, 22 microM; kaempferol, 20 microM; quercetin, 13 microM; morin, 150 microM less than IC50 less than 300 microM.
(19) Changes in the determinants of blood viscosity (packed cell volume, plasma viscosity, red cell aggregation, and red cell deformability) were studied on day 1 and day 5.
(20) Released aggregates of the 19.6-kDa protein were removed from suspension by ultracentrifugation and separated from contaminating membranes by washing in 1.0% sodium dodecyl sulfate (SDS).
Exacerbate
Definition:
(v. t.) To render more violent or bitter; to irriate; to exasperate; to imbitter, as passions or disease.
Example Sentences:
(1) Circuit weight training does not exacerbate resting or exercise blood pressure and may have beneficial effects.
(2) In patients with acute exacerbations of chronic obstructive pulmonary disease, although either sympathomimetic or anticholinergic therapy provides bronchodilatation, no further benefit could be demonstrated from combination therapy.
(3) We report a case of chronic recurrent polymyositis associated with increasing antibody titers of coxsackievirus A9 in serum during clinical exacerbations.
(4) The data indicate that activated helper T cells are required and sufficient to give rise to the inflammatory infiltrates that are characteristic of the inflammations and exacerbations in human rheumatoid arthritis.
(5) The development of renal insufficiency during enalapril therapy may be exacerbated by concomitant diuretic therapy and should raise the suspicion of underlying transplant renal-artery stenosis.
(6) A lysosomal membrane labilizer, vitamin A, exacerbated the cartilage pathology, whereas a stabilizer, cortisone, retarded it.
(7) The utility of a life charting approach is emphasized in delineating past and present course of illness, considering the relevance of cycling pattern and past treatment efficacy in selection of present pharmacological interventions, and helping to formulate a multifactorial concept of the interplay of biological and psychosocial factors in the evolution or exacerbation of mood disorders.
(8) Endotoxins in plasma were monitored during treatment in 18 patients hospitalised for acute exacerbation of Crohn's disease: systemic endotoxaemia was found on admission in all but one.
(9) Exacerbation of inflammation due to repeated traumatization of the oesophagus wall was accompanied by proliferation of the epithelial layers.
(10) Pyoderma gangrenosum is a poorly understood disease characterized by exacerbations and remissions of morphologically unique skin ulcers.
(11) A complex scheme of prophylaxis of exacerbation and progression of chronic bronchopulmonary diseases in children was developed.
(12) The clinical aspects with remission and exacerbation are discussed.
(13) We designed the present study to evaluate the efficacy and safety of cefaclor in the treatment of acute exacerbations of chronic bronchitis in cigarette smokers.
(14) It was demonstrated that neither enflurane nor halothane exacerbates a pre-existing susceptibility to seizure activity and that both these inhalation anaesthetics are suitable for cases suffering from cerebral convulsive disorders.
(15) We conclude that myoglobinuria, of a degree insufficient to cause renal failure itself, can interact with renal ischemia to significantly exacerbate the renal damage produced.
(16) These lymph node reactions could have likely been a part of the so called early exacerbation.
(17) Hyperglycemia exacerbates neurologic damage in clinical and experimental central nervous system ischemia.
(18) Anticoagulation may exacerbate possible tendencies for an ischemic infarction to become hemorrhagic.
(19) (4) Symptoms are exacerbated by a research ward that is disruptive to the community.
(20) This injury was exacerbated to grade 4 (p less than 0.05) following reperfusion but was almost completely healed 24 h later.