(v. t.) To bring together; to collect into a mass or sum. "The aggregated soil."
(v. t.) To add or unite, as, a person, to an association.
(v. t.) To amount in the aggregate to; as, ten loads, aggregating five hundred bushels.
(a.) Formed by a collection of particulars into a whole mass or sum; collective.
(a.) Formed into clusters or groups of lobules; as, aggregate glands.
(a.) Composed of several florets within a common involucre, as in the daisy; or of several carpels formed from one flower, as in the raspberry.
(a.) Having the several component parts adherent to each other only to such a degree as to be separable by mechanical means.
(a.) United into a common organized mass; -- said of certain compound animals.
(n.) A mass, assemblage, or sum of particulars; as, a house is an aggregate of stone, brick, timber, etc.
(n.) A mass formed by the union of homogeneous particles; -- in distinction from a compound, formed by the union of heterogeneous particles.
Example Sentences:
(1) Aggregation was more frequent in low-osmolal media: mainly rouleaux were formed in ioxaglate but irregular aggregates in non-ionic media.
(2) We have examined overlapping octapeptides from the kappa IIIb light chain variable region and show that some framework peptides have the ability to bind aggregated IgG.
(3) Platelet-rich plasma (PRP) was prepared, and platelet aggregation studies were conducted directly or conducted on washed platelets prepared from PRP collected with ACD.
(4) Macrophages internalize aggregated low density lipoprotein (LDL) by LDL receptor-dependent phagocytosis.
(5) Cicaprost is an orally available analogue of PGI2 and has been shown to inhibit platelet aggregation in both in vitro and animal studies.
(6) Only IgG2a and IgG2b myeloma proteins bound readily to IC-21 Fc-receptors, the former in nonaggregated as well as aggregated form, the latter only as aggregated complexes.
(7) When the aggregates occurred on the cell periphery their position coincided with areas free of lamellae.
(8) 2-(4'-Isobutylphenyl)propionic acid, ibuprofen, is an antiinflammatory agent which possesses moderate platelet aggregation inhibitory activity.
(9) In addition, spontaneous platelet aggregation is increased when vegetations are present on cardiac valves.
(10) At concentrations several hundredfold higher than the equivalents present in the minimum concentration of rat skin soluble collagen required for platelet aggregation, neither Hyl-Gal (at 29 muM) nor Hyl-Gal-Glc (at 18 muM) caused platelet aggregation or inhibited platelet aggregation by native collagen.
(11) The mechanisms leading to spontaneous platelet aggregation and thrombocytopenia appear to be similar to those described for other patients with type IIB vWD.
(12) There is approximately a 25% decrease in aggregation from regions of the rib distal to the metaphyseal-growth plate junction (69%) to the region proximal to it (50%).
(13) Laboratory data were aggregated similarly within each study, using the last active drug as a grouping factor.
(14) No correlation could be found between DS content and state of aggregation.
(15) The synthetic S-nitroso-thiol, S-nitroso-N-acetylcysteine, markedly inhibited platelet aggregation with an IC50 of 6 nM.
(16) On the other hand, ultraviolet (320-nm) light, absorbed by 3-hydroxy-pyridinium cross-links which were rapidly photolyzed, partially dissociated polymeric collagen aggregates from bovine Achilles tendon after subsequent heating.
(17) The ternary complex consisting of a 65-kDa peptide originating from the proteoglycan core protein and a 43-kDa link protein bound to hyaluronic acid was purified from a clostripain digest of the rat chondrosarcoma aggregating proteoglycan and 14C-carbamylated with potassium [14C]cyanate.
(18) The IC50 on arachidonic acid-induced platelet aggregation was: fisetin, 22 microM; kaempferol, 20 microM; quercetin, 13 microM; morin, 150 microM less than IC50 less than 300 microM.
(19) Changes in the determinants of blood viscosity (packed cell volume, plasma viscosity, red cell aggregation, and red cell deformability) were studied on day 1 and day 5.
(20) Released aggregates of the 19.6-kDa protein were removed from suspension by ultracentrifugation and separated from contaminating membranes by washing in 1.0% sodium dodecyl sulfate (SDS).
Matrix
Definition:
(n.) The womb.
(n.) Hence, that which gives form or origin to anything
(n.) The cavity in which anything is formed, and which gives it shape; a die; a mold, as for the face of a type.
(n.) The earthy or stony substance in which metallic ores or crystallized minerals are found; the gangue.
(n.) The five simple colors, black, white, blue, red, and yellow, of which all the rest are composed.
(n.) The lifeless portion of tissue, either animal or vegetable, situated between the cells; the intercellular substance.
(n.) A rectangular arrangement of symbols in rows and columns. The symbols may express quantities or operations.
Example Sentences:
(1) Within the outflow tract wall, the labelled cells were enmeshed by strands of alcian blue-stained extracellular matrix.
(2) If ascorbic acid was omitted from the culture medium, the extensive new connective tissue matrix was not produced.
(3) These studies led to the following conclusions: (a) all the prominent NHP which remain bound to DNA are also present in somewhat similar proportions in the saline-EDTA, Tris, and 0.35 M NaCl washes of nuclei; (b) a protein comigrating with actin is prominent in the first saline-EDTA wash of nuclei, but present as only a minor band in the subsequent washes and on washed chromatin; (c) the presence of nuclear matrix proteins in all the nuclear washes and cytosol indicates that these proteins are distributed throughout the cell; (d) a histone-binding protein (J2) analogous to the HMG1 protein of K. V. Shooter, G.H.
(4) Discrimination errors were used to generate a matrix of interletter and interpattern similarities.
(5) The fibrous matrix and cartilage formed within the nonunion site transformed to osteoid and bone with increased vascularity.
(6) A complex linkage between the cytoskeleton and the extracellular matrix is illustrated both in the cord forming Sertoli and granulosa cells, and in the adjacent mesenchymal cells.
(7) Thus, our results indicate that calbindin-D28k is a useful marker for the projection system from the matrix compartment and that its expression is modified in patients with progressive supranuclear palsy and striatal degeneration.
(8) Normal cultured human epidermal melanocytes and melanoma cells derived from three different malignant melanomas were examined for synthesis of extracellular matrix components before and after treatment for one day with interferon-gamma, tumor necrosis factor-alpha, or both.
(9) To exclude potential interactions with components of the extracellular matrix which contains binding sites for PAI-1, ligand binding to HepG2 cells in suspension was assessed.
(10) This was followed by the appearance of microfibrils of various sizes and other components of the extracellular matrix.
(11) The first observable change before the acrosome reaction was a partial decondensation of the acrosomal matrix.
(12) In contrast, boundary layer diffusion is operative in the release from the matrixes prepared by compression of physical mixtures.
(13) Human Caco-2 enterocytes were cultured on matrix proteins (collagen I, laminin, fibronectin) with growth factors (epidermal growth factor [EGF] and transforming growth factor-beta 1 [TGF-beta 1]) and the tyrosine kinase and prostaglandin inhibitors genistein and indomethacin.
(14) As an extension of the previous study which indicated that mesoglea is a primitive basement membrane which has retained some characteristics of interstitial extracellular matrix, the present study was undertaken to analyze the role of mesoglea components during head regeneration in Hydra vulgaris.
(15) Its features are consistent with observed structural dimensions and the molecular periodicities related to transcription, replication and matrix attachment domains.
(16) A significant proportion of the soluble protein of the organic matrix of mollusk shells is composed of a repeating sequence of aspartic acid separated by either glycine or serine.
(17) The increased release of alkaline phosphatase from the particulate matrix by lysophosphatidylcholine was confirmed by disc electrophoresis.
(18) The cytoplasmic matrix was labelled only 30 min after injection.
(19) Type beta transforming growth factor (TGF beta) was shown to regulate the production of several extracellular matrix proteins.
(20) They strongly suggest that the ADP-carrier comes to the close neighbourhood of the ATP synthetase on the matrix side of the inner membrane.