(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Idea
Definition:
(n.) The transcript, image, or picture of a visible object, that is formed by the mind; also, a similar image of any object whatever, whether sensible or spiritual.
(n.) A general notion, or a conception formed by generalization.
(n.) Hence: Any object apprehended, conceived, or thought of, by the mind; a notion, conception, or thought; the real object that is conceived or thought of.
(n.) A belief, option, or doctrine; a characteristic or controlling principle; as, an essential idea; the idea of development.
(n.) A plan or purpose of action; intention; design.
(n.) A rational conception; the complete conception of an object when thought of in all its essential elements or constituents; the necessary metaphysical or constituent attributes and relations, when conceived in the abstract.
(n.) A fiction object or picture created by the imagination; the same when proposed as a pattern to be copied, or a standard to be reached; one of the archetypes or patterns of created things, conceived by the Platonists to have excited objectively from eternity in the mind of the Deity.
Example Sentences:
(1) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(2) In this book, he dismisses Freud's idea of penis envy - "Freud got it spectacularly wrong" - and said "women don't envy the penis.
(3) A backbench policy advisory group will be established to develop ideas.
(4) The idea that 80% of an engineer's time is spent on the day job and 20% pursuing a personal project is a mathematician's solution to innovation, Brin says.
(5) More disturbing than his ideas was Malema's style and tone.
(6) These data, compared with literature findings, support the idea that intratumoral BCG instillation of bladder cancer permits a longer disease-free period than other therapeutical approaches.
(7) The starting point is the idea that the current system, because it works against biodiversity but fails to increase productivity, is broken.
(8) Unlikely, he laughs: "We were founded on the idea of distributing information as far as possible."
(9) On 17 December Clegg will set out his own script for the year ahead, testing the idea that coalition governments can function even as the two parties clearly show their separate colours.
(10) This is about the best experience for our users: the idea that the experience was lacking, the innovation was lacking and we weren't reaching that ubiquity."
(11) Bose grew up with the idea, as the child of a well-to-do Bengali family in Kolkata.
(12) The observations support the idea that the function of pericytes in the choriocapillaris, the major source of nutrition for the retinal photoreceptors, resides in their contractility, and that pericytes do not remove necrotic endothelium during capillary atrophy.
(13) He was really an English public schoolboy, but I welcome the idea of people who are in some ways not Scottish, yet are committed to Scotland.
(14) Differences in scar depression also supported the idea of more stretching in the Dexon group.
(15) These results are consistent with the idea that RPE pigment dispersion is triggered by a substance that diffuses from the retina at light onset.
(16) These conclusions are consistent with those obtained from other techniques and support the idea that the effects of dopamine agonists on the activity of dopamine neurons and globus pallidus cells can provide an indication of the relative selectivity of these drugs for pre- or postsynaptic dopamine receptors.
(17) They also dismiss those who suggest that the current record-low interest rates mean countries could safely stimulate growth by raising their borrowing levels higher: Economists simply have little idea how long it will be until rates begin to rise.
(18) These results favour the idea that the factor present in peak II fraction might behave as an ouabain-like substance.
(19) You could also chat to local estate agents to get an idea of what kind of extension, if any, would appeal to buyers in your area.
(20) When the alternatives are considered, it seems most consistent with Piaget's ideas to regard both cognitive and affective phenomena as problem-solving organizations.