(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Wagon
Definition:
(n.) A wheeled carriage; a vehicle on four wheels, and usually drawn by horses; especially, one used for carrying freight or merchandise.
(n.) A freight car on a railway.
(n.) A chariot
(n.) The Dipper, or Charles's Wain.
(v. t.) To transport in a wagon or wagons; as, goods are wagoned from city to city.
(v. i.) To wagon goods as a business; as, the man wagons between Philadelphia and its suburbs.
Example Sentences:
(1) You wrote I Will Always Love You for Porter Wagoner, even though he had sued you.
(2) The danger is, in the face of western criticism and in the strong belief they have done more than most of their neighbours to be progressive, that they will now circle the wagons.
(3) Samples of fresh grass, wilted grass prior to and after ensiling in a stack silo and cut with either a cylinder-type forage harvester (11.3 mm of length cut) or a self-loading wagon (42.4 mm of length cut), wilted grass prior to and after ensiling in large round bales, and grass hay were obtained from the same field and used for determination of DM and CP degradability.
(4) Tractors accounted for one half of these machinery-related deaths, followed by farm wagons, combines, and forklifts.
(5) Individuals have decided to abandon their own families and jump on the Mandela wagon.
(6) Rail privatisation also saw the end of much domestic locomotive, wagon and carriage building – more workers on the scrapheap, more imports to further transform the balance of payments into a horror story.
(7) Although Knoller and the other young people in the wagon took it in turns to sit and stand, their efforts proved insufficient.
(8) "The meaning of the elections is: Italy can play a role; Italy is not the last wheel of the wagon; Italy is not the bottom of the class.
(9) The train now trundles through silent stations, its wagons free of the crowds of men, women and children who once clung to roofs and ladders.
(10) "The trains had 10 wagons and 100 people squeezed into each one," he says.
(11) If the wagons do start rolling in, I think there will be a massive upsurge,” he says.
(12) Nato thought better of hitching its wagon to the star of the hot-headed Georgian president.
(13) Gulnara Suleymanova and her family of five live in a wagon behind Baku’s prestigious new sports stadium, built especially for next month’s European Games.
(14) The wounded were being loaded into wagons; Wilfred managed to scramble up.
(15) If you then get the right of the party behaving in that way, that’s when you get real trouble and that’s the risk we’ve got at the moment: that there are some in the party all circling the wagon against Jeremy’s campaign.
(16) Secret Trump voters reverse their support: 'He seems to be insane' Read more As the Washington pundits and pollsters wrote them off, there was a sense of circling the wagons.
(17) She had become Snowflake’s unofficial welcome wagon, local therapist and advocate.
(18) "When resources are tight and all our inclinations are to pull the corporate wagons into a circle and fight to defend our own vested interests, that is exactly the time when we need to be at our boldest and most imaginative," he said.
(19) He was bundled into a wooden box which Roland had built specially for the job and then carried in a hand wagon to his Audi 8 car.
(20) 5.48pm BST Summary of today's events: - 196 bodies being stored in refrigerated railway wagons in Torez.