(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Atone
Definition:
(v. i.) To agree; to be in accordance; to accord.
(v. i.) To stand as an equivalent; to make reparation, compensation, or amends, for an offense or a crime.
(v. t.) To set at one; to reduce to concord; to reconcile, as parties at variance; to appease.
(v. t.) To unite in making.
(v. t.) To make satisfaction for; to expiate.
Example Sentences:
(1) Crisis engulfs Gabon hospital founded to atone for colonial crimes Read more At least seven people died and more than 1,000 were arrested in violent protests following the announcement of the election result earlier this month, which the leader of the opposition, Jean Ping, said Bongo, the incumbent, had rigged.
(2) It was on that occasion that then-opposition leader Tony Abbott said , “we have never fully made peace with the first Australians ... we need to atone for the omissions and for the hardness of heart of our forbears to enable us all to embrace the future as a united people”.
(3) As it is, the victims of the 1971 act die un-atoned.
(4) Morrison, atoning for his earlier miss, drilled home Rondón’s acrobatic cutback to pull a goal back for Albion but within seven minutes Chelsea had a third.
(5) But the Conservatives should be asking Kaminski to withdraw his statements about Jedwabne, apologise for his attacks on a brave Polish president, Alexander Kwasniewski, who, like Willy Brandt, was willing to make symobolic atonement for the crimes done to Jews in the second world war.
(6) Atonic drop attacks appear to be a common cause of ictal epileptic falling in MAEE.
(7) Callosotomy proved efficient in controlling atonic fits in 10 out of 15 patients in whom surgical results are evaluated.
(8) The two countries are locked in a long-running territorial dispute over uninhabited islands in the East China Sea , known as the Diaoyu to the Chinese and Senkakus to the Japanese, and China complains Japan has failed to fully atone for its brutality in the second world war.
(9) 1 The action of three polypeptides, bradykinin, substance P and eledoisin known to inhibit vascular smooth muscle has been examined on the anococcygeus muscle of the rat, cat and rabbit.2 In the atonic rat muscle, bradykinin and substance P had little or no effect on tone but eledoisin produced a sustained dose-related contraction which could be abolished by phentolamine (1 muM) and is, therefore, probably an indirect sympathomimetic effect.
(10) If we lived in the Roman era, the driving goal of our culture might have been dignity; in the dark ages, honour, in the middle ages, atonement.
(11) Equally, punishment must be proportionate and fair and those who are incarcerated must have the prospect of atonement and rehabilitation.
(12) Direct observation of an atonic uterus at cesarean section supported other evidence that uterine muscle may be affected.
(13) One woman suffered from atonic post-partum haemorrhage.
(14) 8 findings specific to endometriosis and the scores were as follows: Dysmenorrhea (1), dyspareunia (3), retroverted uterus (3), cul-de-sac nodularities (3), atonic (1) and marginal irregularity (1) of uterus, and perifimbrial adhesion (2) in hysterosalpingography, and unexplained infertility (2).
(15) In our case, atonic partial seizure was associated with nonepileptic equilibrium impairment, probably due to cerebral cortex dysfunction.
(16) According to urodynamic findings the patients were divided into 2 groups: group 1 consisted of 9 neonates (30 per cent) with detrusor-sphincter dyssynergia and high pressure, decreased-compliance bladders, and group 2 consisted of 21 children (70 per cent) with atonic bladders and low pressure, reduced-compliance bladders without dyssynergia.
(17) Treatment can vary from none at all (eg, in the child with a single febrile seizure) to the use of more than one drug and the ketogenic diet (eg, in poorly controlled atypical absence, atonic, and some myoclonic disorders).
(18) Similar complaints may occur in elderly people or in women with gynaecological problems owing to atonic urinary retention.
(19) 5 women had abnormal gestations visible macroscopically, by their green, brown, clotted, folded or atonic gestational sac.
(20) -- Intravenous infusion of per-minute amounts between 40 and 80 micrograms in cases of atonic haemorrhage or between 30 and 45 micrograms in the placental period, in general, produced uterine contraction and clearly reduced blood loss.