(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Gone
Definition:
(p. p.) of Go
() p. p. of Go.
Example Sentences:
(1) Critics say he is unelectable as prime minister and will never be able to implement his plans, but he has nonetheless pulled attention back to an issue that many thought had gone away for good.
(2) Even if it were not the case that police use a variety of tricks to keep recorded crime figures low, this data would still represent an almost meaningless measure of the extent of crime in society, for the simple reason that a huge proportion of crimes (of almost all sorts) have always gone unreported.
(3) Osman had gone close before that, flashing a shot over from seven yards after a corner.
(4) Bobbing in warming waters, this ancient ice fossil will be gone in a couple of weeks.
(5) The authors are also upfront about what has not gone so well: "We were too slow to mobilise … we did not identify clear leadership or adequate resources for the actions … it is vital to accelerate the programme of civil service reform."
(6) Super City have Gone Holistic, to borrow the buzzword they introduced after Pellegrini had replaced Mancini.
(7) Half a million homes were sold in Scotland, we lost a huge, huge chunk of stock, and as house prices began to escalate so any asset to the community has gone.
(8) When Vladimir Putin kicks back on New Year's Eve with a glass of Russian-made champagne, and reflects on the year behind him, he is likely to feel rather pleased with himself at the way his foreign policy initiatives have gone in 2013.
(9) We just hope that … maybe she’s gone to see her friend, talk some sense into her,” Renu said, adding that Shamima “knew that it was a silly thing to do” and that she did not know why her friend had done it.
(10) "We've gone out as a company and taken a risk without the taxpayers having to put up the money.
(11) Nan had gone away for a weekend Prayathon and Mack had taken Katie and Missy to a shack in Oregon.
(12) The problem is that every day that this solution has been delayed the price (more precisely: the headline figure) has gone up.
(13) At one point, shortly after Suárez had given them a 3-0 lead, a loud cry had gone up from the Liverpool end of "We're going to win the league".
(14) He is said to have gone to Syria in spring this year, according to Belgian newspaper Het Laatste Nieuws .
(15) Speaking about the player, who scored crucial goals for England during qualification for the 2014 World Cup, Hodgson said: “Andros was unlucky to lose his place in the squad when he wasn’t getting a regular game and he’s gone to Newcastle, got a regular game, and done very well there.” Expressing his delight in being selected, Townsend tweeted: “Huge honour to be named in provisional England squad for the euros ... Will give my all over next few weeks to try to make final squad!” Hodgson also declared himself pleased to include Jordan Henderson, who returned to action for Liverpool in Sunday’s 1-1 draw with West Bromwich Albion having been out since early April with damaged knee ligaments.
(16) The Assyrian Empire, though it did fluctuate in strength, had gone down finally over six hundred years before this scene is set.
(17) When that prescription was gone, he said he was still in pain, so the doctor wrote a second prescription.
(18) Factors in favour of an inquiry include the seriousness of the allegations and the fact they have not gone away, plus the fact a threshold for a public inquiry is relatively low.
(19) Besides, Francis says, once their reformation had gone on longer than their initial career, the rest of the band were starting to feel wary about just playing the old material, particularly when they found themselves booked to play a Canadian casino, the kind of venue that is traditionally the preserve of oldies acts: "It was just sort of symbolic, like ha-ha, here we are, at the casino.
(20) And despite the initial scepticism, now completely gone says Henry, DCA's transparency and accountability systems and mechanisms are now "some of the most convincing tools to fundraising, credibility and brand recognition" and is used by face-to-face fundraisers, volunteers and PR to promote the organisation.