What's the difference between agonism and struggle?

Agonism


Definition:

  • (n.) Contention for a prize; a contest.

Example Sentences:

  • (1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
  • (2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
  • (3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
  • (4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
  • (5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
  • (6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
  • (7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
  • (8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
  • (9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
  • (10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
  • (11) In the inferior parietal cortex, agonal status confounded this comparison.
  • (12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
  • (13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
  • (14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
  • (15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
  • (16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
  • (17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
  • (18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
  • (19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
  • (20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.

Struggle


Definition:

  • (v. i.) To strive, or to make efforts, with a twisting, or with contortions of the body.
  • (v. i.) To use great efforts; to labor hard; to strive; to contend forcibly; as, to struggle to save one's life; to struggle with the waves; to struggle with adversity.
  • (v. i.) To labor in pain or anguish; to be in agony; to labor in any kind of difficulty or distress.
  • (n.) A violent effort or efforts with contortions of the body; agony; distress.
  • (n.) Great labor; forcible effort to obtain an object, or to avert an evil.
  • (n.) Contest; contention; strife.

Example Sentences:

  • (1) They had learned through hard experience what Frederick Douglass once taught -- that freedom is not given, it must be won, through struggle and discipline, persistence and faith.
  • (2) This is a struggle for the survival of our nation.” As ever, after Trump’s media dressing-down, his operation was quick to fit a velvet glove to an iron fist.
  • (3) Slager, 33, was a patrolman first class for the North Charleston police department when he fatally shot Scott, 50, following a struggle that led from a traffic stop when the officer noticed that one of Scott’s car tail lights was broken.
  • (4) For a union that, in less than 25 years, has had to cope with the end of the cold war, the expansion from 12 to 28 members, the struggle to create a single currency and, most recently, the eurozone crisis, such a claim risks accusations of hyperbole.
  • (5) He said: “Almost daily we hear from parents desperate to escape the single cramped room of a B&B or hostel that they find themselves struggling to raise their children in.
  • (6) Nevertheless we know that there will remain a large number of borrowers with payday loans who are struggling to cope with their debts, and it is essential that these customers are signposted to free debt advice.
  • (7) Its struggling mobile phone business resulted in a net loss of 136 billion yen for the three months to September, although that figure was smaller than analysts had predicted.
  • (8) They took 15% in 2010, with the other parties caught in a scrappy three-way struggle in which the winning Lib Dems came in below 30%.
  • (9) Likewise, Blanchett's co-star Alec Baldwin appeared to call for an end to the public nature of the row, terming Dylan's allegations "this family's personal struggle".
  • (10) RIM has always struggled to explain to the authorities that, unlike most other companies, it technically cannot access or read the majority of the messages sent by users over its network.
  • (11) But she has struggled – quite awkwardly – to articulate her evolution on same-sex marriage, and has left environmental activists wondering what her exact energy policy is.
  • (12) They anticipated the following scenario: a struggling club fires its manager and enjoys an immediate upsurge.
  • (13) While Greece struggled to find a new leader, the spotlight turn dramatically to Italy.
  • (14) Losing Murphy is a blow to the Oscars which has struggled to liven up its image amid a general decline in its TV ratings over the last couple of decades and a rush of awards shows that appeal to younger crowds, such as the MTV Movie Awards.
  • (15) They had been pinning their hopes on Alan Johnson who has, in their eyes, the natural authority and ease of manner which Miliband has struggled to develop.
  • (16) The real change is coming from the community-led frontline struggles.
  • (17) As ABC reports, Adam Bandt, the only Greens MP in the lower house, won his Melbourne seat with the help of Liberal preferences at the last election, and may struggle to hold it on 7 September.
  • (18) I have always struggled with the quality of my own work but despite my misgivings about the photos I am taking I can't honestly say they would have been any better two years ago.
  • (19) Braff will direct and play the lead role of a father, actor and husband struggling to find his identity.
  • (20) Young people from ordinary working families that are struggling to get by.” Labour said Greening’s department had deliberately excluded the poorest families from her calculations to make access to grammar schools seem fairer and accused her of “fiddling the figures”.

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