(n.) One who contends for the prize in public games.
Example Sentences:
(1) alpha 1-Adrenergic agonists, phenylephrine and norfenefrine, did not affect the synthesis.
(2) Data obtained with fenoldopam were corroborated with use of SK&F 38393, another dopamine D1-receptor agonist.
(3) The GABA receptor agonist progabide reduced VCMs and locomotor activity.
(4) This novel mechanism of receptor regulation, named transmodulation, should be distinguished from the reduction in total receptor number caused by the homologous ligand (downregulation) and from the change in affinity produced by the binding of agonists or antagonists to the same receptor site.
(5) Exposure to nanomolar concentrations of saralasin, an Ang II agonist, attenuated the passage of the fluorophores across the monolayers by 50-75%.
(6) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(7) The binding to DNA-cellulose of heat-activated [3H]RU486-receptor complexes was slightly decreased (37%) when compared with that of the agonist [3H]R5020-receptor complexes (47%).
(8) These later results suggest that dopamine agonists increase sensorimotor reactivity measured with acoustic startle by acting on sensory rather than motor parts of the reflex arc.
(9) Only methoxyindole acetic acid was detectable after incubation of unstimulated and alpha-adrenergic-agonist-treated pineal glands.
(10) It inhibits platelet and vascular smooth muscle activation by cGMP-dependent attenuation of the agonist-induced rise of intracellular free Ca2+.
(11) The elimination half-life of most beta-agonists is relatively short, and pharmacokinetics are independent of dose and duration of treatment.
(12) Substance P (SP), a relatively non-selective tachykinin receptor agonist, and Septide and Senktide, highly selective NK-1 and NK-3 tachykinin receptor agonists, respectively, were injected intradermally in rats.
(13) Responses of control tissues to an alpha agonist (norepinephrine) were increased at lower temperatures and responses to a beta agonist (isoprenaline) were increased at higher temperatures.
(14) The inhibition of all three agonist responses by 1.1 mM calcium was competitive.
(15) The alpha 2 agonist, clonidine, produced a larger dose-related increase in food intake in lean rats than in the fatty rats.
(16) This stimulation is mediated by one receptor with an apparent affinity of 3.3 X 10(-6) M. The hydroxyl group in the para position on phenylethanolamine was absolutely necessary to obtain an agonist whereas the meta hydroxyl group or the presence of a catechol almost suppressed the activity.
(17) The alpha 2-adrenoceptor agonist clonidine is most potent for stimulating Isc.
(18) Moreover, the ribosylation inhibitors converted the glucocorticoid antagonist RU-486 into a potent agonist for cytolysis of L1210 cells.
(19) We have characterized the effects of adenosine, the A1-receptor agonist N6-(L-2-phenylisopropyl)-adenosine (PIA) and the A2-receptor agonist 5'-(N-ethyl)-carboxamido-adenosine (NECA), in isolated human pulmonary vessels.
(20) Long-term treatment with agents that stimulate the beta-receptor (prenalterol and pirbuterol) has not proved to be useful in the treatment of chronic heart failure; moreover, prolonged treatment with beta-agonists (dobutamine and pirbuterol) may adversely affect survival.
Agony
Definition:
(n.) Violent contest or striving.
(n.) Pain so extreme as to cause writhing or contortions of the body, similar to those made in the athletic contests in Greece; and hence, extreme pain of mind or body; anguish; paroxysm of grief; specifically, the sufferings of Christ in the garden of Gethsemane.
(n.) Paroxysm of joy; keen emotion.
(n.) The last struggle of life; death struggle.
Example Sentences:
(1) "The new feminine ideal is of egg-smooth perfection from hairline to toes," she writes, describing the exquisite agony of having her fingers, arms, back, buttocks and nostrils waxed.
(2) It has been awfully hard-won, carved slowly out of a big block of human agony.
(3) Her agony and her rapture stay interior, and they flip-flop like nerves in this beautiful, grave black-and-white movie.
(4) Those who remember the Two Davids of the 1987 SDP-Liberal Alliance will recall the exquisite agony only too well, cruelly captured by the Spitting Image puppet of little Steel perched in big Owen's pocket.
(5) Using male and female Wistar rats, pituitary response to cardiac and respiratory failure type (CFT and RFT) sudden death caused by the intravenous administration of KC1 and SCC, respectively, was examined by analyzing variation in pituitary immunoreactive beta-endorphin (IR-beta-EP) levels determined by radioimmunoassay after death and in circulating IR-beta-EP levels during periods of agony.
(6) I was in the surgical ward at Westmorland General Hospital on Kendal Green, and it was agony.
(7) I'd go after work and he'd paint till 1 or 1.30 in the morning, and it was agony lying there on the floor.
(8) Evidently fuelled by the agony of losing a series twelve months ago when the trophy was almost within their grasp, they also had the teamwork, technique and experience to turn their quest for revenge into a reality.
(9) Facebook Twitter Pinterest Even those who’ve never seen a downhill ski race couldn’t help but sympathise with Bode Miller’s agony at missing out on a medal in what will surely be the last Olympic event of his career.
(10) "When the disaster was big enough," King writes, "agony and violent death had an enriching quality."
(11) Even at UCH, when no one was there for us and my father, having not slept for almost 30 hours, was pulling his hair out in agony, I tried to look at it all as a kind of comedy of errors."
(12) They were subject, of course, to the prison censor, but the agony over Winnie, and the passion of which that agony was a product, blazes through them.
(13) That he ended up in the dock in The Hague at all surprised many who have studied the man and his country's agony through the 1990s.
(14) Shawcross, however, maintains there was no bad intent and said for that reason he has not been tormenting himself about the moment he collided with Ramsey's right leg and left the teenager writhing in agony.
(15) He notes the uneven agony - 80% will land in developing countries.
(16) The poor animals are thrown back into the water to die in agony, a practice condemned by environmental campaigners.
(17) The rest was pure agony for the Australians, give or take a yellow card for Sonny Bill Williams, given for a dangerous tackle.
(18) The woman before you in agony pushing and pushing, losing all dignity, does not care one bit whether I am feeling alarmed at her screaming, worried about where I should be standing, wondering whether I should rub her back or try and make small talk between contractions.
(19) Litvinenko sipped “three or four times” from a cup of radioactive tea, and died in agony 23 days later, the inquiry heard last week.
(20) Our most excruciating agony is of not being noticed in the world.