(1) alpha 1-Adrenergic agonists, phenylephrine and norfenefrine, did not affect the synthesis.
(2) Data obtained with fenoldopam were corroborated with use of SK&F 38393, another dopamine D1-receptor agonist.
(3) The GABA receptor agonist progabide reduced VCMs and locomotor activity.
(4) This novel mechanism of receptor regulation, named transmodulation, should be distinguished from the reduction in total receptor number caused by the homologous ligand (downregulation) and from the change in affinity produced by the binding of agonists or antagonists to the same receptor site.
(5) Exposure to nanomolar concentrations of saralasin, an Ang II agonist, attenuated the passage of the fluorophores across the monolayers by 50-75%.
(6) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(7) The binding to DNA-cellulose of heat-activated [3H]RU486-receptor complexes was slightly decreased (37%) when compared with that of the agonist [3H]R5020-receptor complexes (47%).
(8) These later results suggest that dopamine agonists increase sensorimotor reactivity measured with acoustic startle by acting on sensory rather than motor parts of the reflex arc.
(9) Only methoxyindole acetic acid was detectable after incubation of unstimulated and alpha-adrenergic-agonist-treated pineal glands.
(10) It inhibits platelet and vascular smooth muscle activation by cGMP-dependent attenuation of the agonist-induced rise of intracellular free Ca2+.
(11) The elimination half-life of most beta-agonists is relatively short, and pharmacokinetics are independent of dose and duration of treatment.
(12) Substance P (SP), a relatively non-selective tachykinin receptor agonist, and Septide and Senktide, highly selective NK-1 and NK-3 tachykinin receptor agonists, respectively, were injected intradermally in rats.
(13) Responses of control tissues to an alpha agonist (norepinephrine) were increased at lower temperatures and responses to a beta agonist (isoprenaline) were increased at higher temperatures.
(14) The inhibition of all three agonist responses by 1.1 mM calcium was competitive.
(15) The alpha 2 agonist, clonidine, produced a larger dose-related increase in food intake in lean rats than in the fatty rats.
(16) This stimulation is mediated by one receptor with an apparent affinity of 3.3 X 10(-6) M. The hydroxyl group in the para position on phenylethanolamine was absolutely necessary to obtain an agonist whereas the meta hydroxyl group or the presence of a catechol almost suppressed the activity.
(17) The alpha 2-adrenoceptor agonist clonidine is most potent for stimulating Isc.
(18) Moreover, the ribosylation inhibitors converted the glucocorticoid antagonist RU-486 into a potent agonist for cytolysis of L1210 cells.
(19) We have characterized the effects of adenosine, the A1-receptor agonist N6-(L-2-phenylisopropyl)-adenosine (PIA) and the A2-receptor agonist 5'-(N-ethyl)-carboxamido-adenosine (NECA), in isolated human pulmonary vessels.
(20) Long-term treatment with agents that stimulate the beta-receptor (prenalterol and pirbuterol) has not proved to be useful in the treatment of chronic heart failure; moreover, prolonged treatment with beta-agonists (dobutamine and pirbuterol) may adversely affect survival.
Hostility
Definition:
(n.) State of being hostile; public or private enemy; unfriendliness; animosity.
(n.) An act of an open enemy; a hostile deed; especially in the plural, acts of warfare; attacks of an enemy.
Example Sentences:
(1) Some of their most cherished objectives, such as parliamentary reform, have been left as roadkill by the juggernauts of Tory and Labour hostility.
(2) Mars is a much more hostile environment than people realise, they point out.
(3) It's an attractive idea, and yet pride in Europe appears to be giving way to populism and hostility within the union.
(4) But even among the most hostile voters, only a third put Europe among the most crucial issues facing the country.
(5) Afghan officials in the past have expressed fears that soldiers sent to Pakistan could be recruited as spies or that their careers would be stunted by the deep hostility that Afghans harbour towards Pakistan.
(6) Michael Holroyd, in his biography of George Bernard Shaw , gives an illuminating example of myopic hostility to Russia by the right even when we desperately needed allies.
(7) Overall, these results suggest that future research should investigate variables in addition to hostility in regard to risk for and protection from CHD.
(8) As important, if not more so, as his ambition to make exams tougher is his hostility towards other measures of ability, such as course work and controlled assessments.
(9) Journalists are being told to speak to public affairs office, but the public affairs office doesn't call them back or is hostile."
(10) Green groups were hostile or reacted cautiously to the report.
(11) To assess physiological and psychological states accompanying anabolic-androgenic steroid use, male weight lifters 1) were interviewed regarding their physical training and the patterns and effects of any drug use; 2) completed a written physical and medical history questionnaire, a Profile of Mood States questionnaire, and the Buss-Durkee Hostility Inventory; and 3) were physically examined, including a blood sample and urinalysis.
(12) The sugar tax was greeted with hostility by the industry and Wright argues that the levy, introduced by the chancellor in the budget , will be undermined by flawed analysis of its impact.
(13) Murdoch had one on his, of course, but because he was facing hostile interrogation he looked (unfairly) as if he were wearing it in self-protection as a symbol of his own virtue.
(14) Tory MEP Nirj Deva was one of several deputies to subject Mr Nielson to hostile questioning.
(15) Yet, the long list of allegations included no statement from Kenneth Bae, other than claims that he confessed and didn't want an attorney present during his sentencing last week for what Pyongyang called hostile acts against the state.
(16) We are effectively now placed in co-sovereignty with a hostile power.
(17) The inquiry’s chairman, Sir Thayne Forbes, a former high court judge, concluded in 2014 that the most serious claims were “deliberate lies, reckless speculation and ingrained hostility”.
(18) Faced with ever growing hostility to the EU, and to immigration, Clegg has decided to present the Liberal Democrats unambiguously as the party of "in" and of openness.
(19) The aim of this study was to determine how individual differences in cynical hostility and defensiveness interacted with situational demands to affect cardiovascular responses in a natural setting.
(20) The Saudis and other Gulf states still support rebel fighting formations – as much because of inertia and hostility to Iran as anything else – but western backing is on a downward trajectory as concerns mount about the risks of blowback from al-Qaida-linked groups.