What's the difference between agonized and somber?
Agonized
Definition:
(imp. & p. p.) of Agonize
Example Sentences:
(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Somber
Definition:
(v. t.) Alt. of Sombre
(a.) Alt. of Sombre
(n.) Alt. of Sombre
Example Sentences:
(1) Melanomas developed on giant pigmented naevi had a particularly somber prognosis: death occurred within 6, 7 and 3 months respectively in the 3 cases observed.
(2) Uncompleted mourning and the depression and somber states of mind it created were absorbed by their children from birth on.
(3) In these very old people with very somber prognosis, anemia was corrected by surgery without recurrence after 8 and 10 months respectively.
(4) If Trump seems strangely incapable of consistency except in the matter of walling out and deporting immigrants, somber Ted Cruz is lurking nearby to alarm us with his ideological purity.
(5) Although most readers consider medical publications to be somber and somnifacient, a critical eye will discover a remarkable array of absurdities and assorted other oddities, totally unintended by the authors.
(6) Almost every report on macular degeneration begins with a somber reminder that macular degeneration is the single most common cause of blindness in the elderly in the United States and Europe.
(7) 'A lot of the movements to combat violence against women are somber.
(8) Coronary lesions with atheromatous deposits occurring in later childhood characterize homozygous type IIa hypercholesterolaemia and condition the somber prognosis of a disease which affects one subject in a million.
(9) The statement read: It is with a heavy heart and somber mind that we remember and honor the victims, survivors, heroes of the Holocaust.
(10) The day after the election, I walked around the camp and it was really somber,” said Kandi Mossett, a member of the Mandan, Hidatsa and Arikara tribes who has been camping at Standing Rock since mid-August.
(11) The mood was somber, and many people wiped away tears.
(12) She suggests that the question for anyone considering standing for the US presidency should be: “What’s your vision for America?” Then she supplies her own answer: “The challenge is to lead in a way that unites us again and renews the American Dream … Ultimately, what happens in 2016 should be about what kind of future Americans want for themselves and their children – and grandchildren.” The start of the book is more somber.
(13) Since President Barack Obama took office, there have been at least 16 major mass shootings, after which he has offered somber words of condolence and called for national healing.
(14) In 1811 Mary Reynolds, a somber Pennsylvania spinster, awoke from a prolonged sleep as a new personality.
(15) This discussion forms the basis of a review of the worldwide literature, but stresses two problems which determine the prognosis: that of diagnosis, which in the majority of cases is very late, and that of their prognosis, which remains somber because of their tendency to metastasize by blood-borne spread and that of locoregional recurrences.
(16) In a strong but somber voice, McDonnell told the judge before sentencing that he was “a heartbroken and humbled man” and that he holds himself accountable.
(17) In other essays, she tries to educate a caddish boyfriend by sharing wisdom from He’s Just Not That Into You , and unexpectedly surrenders to the madness of wedding gown shopping, in which “dresses are brought out from back rooms with somber reverence, like the Torah being revealed from the ark”.
(18) She did not answer a question about whether Trump did not want to offend people, saying only: “It was our honor to issue a statement in remembrance of this important day.” In its original statement, the White House said: “It is with a heavy heart and somber mind that we remember and honor the victims, survivors, heroes of the Holocaust .
(19) At the International Brotherhood of Electrical Workers Local 369 hall in Louisville, where supporters had hoped to celebrate a Grimes win, the mood quickly turned somber: one minute, a few young employees were playing stickball while waiting for the party to start, and the next the hall was empty, as the few people who had arrived before the race was called went up to the war room to commiserate and watch the results of the statehouse races.
(20) Despite significant advances in many areas, the morbidity and mortality statistics remain as somber reminders of the devastation attributed to this epidemic.