What's the difference between agonized and sombre?
Agonized
Definition:
(imp. & p. p.) of Agonize
Example Sentences:
(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Sombre
Definition:
(v. t.) To make somber, or dark; to make shady.
(a.) Dull; dusky; somewhat dark; gloomy; as, a somber forest; a somber house.
(1) Photograph: KHIZR KHAN This sombre, serene oasis overlooking the Potomac river might also prove the graveyard of Donald Trump’s ambitions for the US presidency.
(2) Seethetree Kingley Vale, Sussex Forget the colours of autumn; this place is sombre in colour and atmosphere but you will be walking among probably the oldest living organisms in Britain.
(3) Slowing growth, financial fragility, governments teetering on the brink of insolvency and default, and clear signs of a public backlash against the excesses of the rich and powerful: all have created a sombre backdrop to the invitation-only affair.
(4) King gave a sombre assessment of the government's challenge at a press conference to launch the Bank's quarterly inflation report.
(5) Top floor: a roomful of sombre youths vying for individual supremacy using some form of networked arcade strategy game that uses collectible cards.
(6) In sombre tones he did indeed acknowledge that there are no sunny uplands as we "now face a crisis that is the economic equivalent of war" .
(7) In March 1990, in a ceremony in the new Congress building built by Pinochet in his home town of Valparaiso - 80 miles from the capital, Santiago, and intended to remain well out of mind of the real centres of power - a sombre Pinochet handed the presidential sash over to Aylwin.
(8) Q has upped his gadget game Facebook Twitter Pinterest The brooding and sombre Skyfall scored a few points for post-modern playfulness via its introductory scene for the new Q, in which Ben Whishaw might as well have offered Bond a couple of Netflix vouchers and a year’s subscription to Cosmopolitan for all the wow factor his proffered “gadgets” achieved.
(9) Another report, Sir Derek Wanless's Securing Good Health for the Whole Population (2004), set out the sombre consequences of our slobby habits: life expectancy cut by nine years, increased coronary heart disease and diabetes, and a cost of £8.2bn to the economy.
(10) She’s very serious in her style, very well-informed in her style, it won’t be the same as David Cameron,” he said, welcoming the idea of a more sombre tone.
(11) In a sombre closing speech, Clegg warned of "a long hard road ahead", and said the economy was "our biggest concern" because "the recovery is fragile".
(12) A grand and sombre staircase - dark, looming, pitiless - leads up from the Axes to the exhibits, allowing Libeskind to play one last trick on the visitor by luring him up a final flight that goes nowhere, before his voice gives way to the memoranda of Jewish history.
(13) It is now recognized that as much as left ventricular dysfunction these ventricular arrhythmias are of sombre prognosis.
(14) South Africans have undergone sombre introspection of late with the economy slowing, unemployment sky highand, worst of all, violent unrest that included the killing of workers at the Lonmin platinum mine in August.
(15) Helen Hunt and John Hawkes are deservedly recognised for their fine performances in The Sessions, while Kathryn Bigelow 's sombre, gripping Zero Dark Thirty bags a quartet of nominations, burnishing its credentials as the dark horse of this year's Oscar race.
(16) There were reports this morning that Gaga was reluctant to perform after the death of Alexander McQueen last week and had told organisers she would only play a set that was suitably sombre (with images of McQueen projected as a backdrop apparently).
(17) In a sombre letter to his youngest child, Mohamed wrote: "Sorry because you were born where free people are behind bars, including your father."
(18) Although they may draw images of sombre and disciplined technicians in white coats, labs in the modern industrial context are a nebulous idea.
(19) Although relatively rare, stenosis must be diagnosed in view of its sombre spontaneous prognosis (one patient died 3 days after coronary arteriography), of the risk of underestimating its frequency, and of the hazards of selective coronary catheterization in such patients (one of our patients died 15 minutes after coronary exploration).
(20) In a sombre ceremony, the eight men were remembered and honoured by name as families and relatives paid their last respects.