(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Distressing
Definition:
(p. pr. & vb. n.) of Distress
(a.) Causing distress; painful; unpleasant.
(adv.) In a distressing manner.
Example Sentences:
(1) Perinatal mortality is strongly associated with obstetrical factors, respiratory distress syndrome, and prematurity.
(2) No respiratory-distress syndrome of the newborn occurred when total amniotic-fluid cortisol was greater than 60 ng per milliliter (16 patients).
(3) Early views of the Type A behaviour pattern (TABP) sought to disengage it from either neuroticism or emotional distress.
(4) Sleep alterations in addicted newborns could be related to central nervous system (CNS) distress caused by withdrawal.
(5) For many it had still a moderating effect on distress at the present but appeared to be mainly used out of "psychological dependence".
(6) Marie Johansson, clinical lead at Oxford University's mindfulness centre , stressed the need for proper training of at least a year until health professionals can teach meditation, partly because on rare occasions it can throw up "extremely distressing experiences".
(7) In contrast, the number of distressful childhood experiences reported was generally unrelated to empathy scores.
(8) The lavage model was considered suitable for reproduction of severe respiratory distress.
(9) Twenty-seven infants with respiratory distress and hypoxemia of noncardiac etiology were treated with tolazoline.
(10) A clearly recognizable relationship of SEH to gestational age and clinical status exists in that all SEH occur in premature infants under 2500 g birthweight (although only 56% of all premature infants have SEH) and 95% of SEH occur in infants with the respiratory distress syndrome (although only 60% of infants with the respiratory distress syndrome have SEH).
(11) Four hours after infusion, the animals displayed a clinical and pathological pattern which closely resembled post-traumatic acute respiratory distress syndrome, including hypoxia, hypocarbia, thrombocytopenia, increased pulmonary capillary permeability to albumin, interstitial edema, hypertrophy of alveolar lining cells, and intra-alveolar hemorrhage.
(12) In turn, nursing strategies that are selected as a result of such theoretically based assessments are likely to be effective in preventing spiritual distress.
(13) There is no support in the system and it’s a very frightening and distressing situation to be in.
(14) Therefore, after head injuries we searched for C activation because it could result in the adult respiratory distress syndrome (ARDS).
(15) It has to be assumed that in calves with respiratory distress syndrome--in analogy to pulmonary immaturity--the blood clotting mechanism is not yet fully developed.
(16) At birth, the animals were in no distress but had mild pulmonary hypertension.
(17) If these recordings are repeated before or at the same time as other signs of fetal distress have been found we must think of pathological features such as intrauterine growth retardation, post-maturity, infections, rhesus incompatibility and diabetes.
(18) Sustained intubation (7 days) was necessary in only two infants because of developing respiratory distress as a result of prematurity or recurrent pleural fluid accumulation.
(19) Financial experts aren't immediately sure what to make of the report, but one theory is that the figure includes the 'profits' the European Central Bank has made by buying Greek debt at distressed levels since the crisis began: econhedge (@econhedge) suggestion that this is planned EUR31.5b+ECB profits.
(20) The results do not indicate any disorder in liver and muscle functions in prematurely born calves with or without respiratory distress syndrome.