(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Grievous
Definition:
(a.) Causing grief or sorrow; painful; afflictive; hard to bear; offensive; harmful.
(a.) Characterized by great atrocity; heinous; aggravated; flagitious; as, a grievous sin.
(a.) Full of, or expressing, grief; showing great sorrow or affliction; as, a grievous cry.
Example Sentences:
(1) With grievous amazement, never self-pitying but sometimes bordering on a sort of numbed wonderment, Levi records the day-to-day personal and social history of the camp, noting not only the fine gradations of his own descent, but the capacity of some prisoners to cut a deal and strike a bargain, while others, destined by their age or character for the gas ovens, follow "the slope down to the bottom, like streams that run down to the sea".
(2) The Meikhtila district chairman, Tin Maung Soe, said one Buddhist man was sentenced to five years' imprisonment on Thursday for causing grievous harm in connection with the killing of two Muslim men.
(3) Through small and large acts of deprivation and destruction we follow the process: the removal of hope, of dignity, of luxury, of necessity, of self; the reduction of a man to a hoarder of grey slabs of bread and the scrapings of a soup bowl (wonderfully told all this, with a novelist's gift for detail and sometimes very nearly comic surprise), to the confinement of a narrow bed – in which there is "not even any room to be afraid" – with a stranger who doesn't speak your language, to the cruel illogicality of hating a fellow victim of oppression more than you hate the oppressor himself – one torment following another, and even the bleak comfort of thinking you might have touched rock bottom denied you as, when the most immediate cause of a particular stress comes to an end, "you are grievously amazed to see that another one lies behind; and in reality a whole series of others".
(4) "This has very serious ramifications with potentially grievous consequences for the country," the military said.
(5) Yet his team held out when the consequences could have been much more grievous.
(6) On Sunday, his department was confronted with the deadliest mass shooting in American history: at least 50 dead, 53 wounded, many in grievous condition.
(7) Meanwhile he was grievously wanting in that other great, complementary task - the building of his state in the making.
(8) But they did Aboriginal and Torres Strait Islander people a grievous, hurtful, harmful wrong on many levels and this includes failing to include a single positive word about us anywhere in the constitution of modern Australia.
(9) The Chelsea manager responded with a smile and a little wave, then settled back to watch his team inflict another grievous setback to Moyes's first season at this level.
(10) For Arsenal it would have been a grievous setback if they had allowed a side with these shortcomings to pinch a late equaliser.
(11) It adds grievous insult to injury that a mother going through the turmoil that Fatima was experiencing should have to listen to this response.
(12) When Blair Peach was struck on the head during the demonstration against the National Front, he was a victim not only of the police but of a barely suppressed public attitude – encouraged by a large portion of the media – that people who went on such protests were troublemakers who deserved all that they got – and if police officers cracked a few heads, then they had probably been grievously provoked by the troublemakers.
(13) For him, "a world in which we are no longer burdened by debt, credit, hock, mortgage, HP, might not be a grievous loss but a deliverance … a more modest and more prudent way of living".
(14) Wolfsburg’s André Schürrle ends CSKA Moscow’s Champions League hopes Read more Depay had a difficult game against his old club and his first half-season at Old Trafford is straying dangerously close to the point where his confidence suffers grievous damage.
(15) But in 2000 he was jailed for grievous bodily harm after stabbing a man in the face following a row that was reported at the time to have had racial overtones.
(16) Abortion law "ijhad" in Kuwait was amended in 1982 to permit abortion where either grievous bodily harm to the mother is imminent or it is proved that the baby will suffer incurable brain damage or severe mental retardation.
(17) My friend was grievously injured and bleeding profusely.
(18) All three deny causing grievous bodily harm with intent.
(19) Asked about the potential consequences of the executions, Abbott said: “We will be letting Indonesia know in absolutely unambiguous terms that we feel grievously let down.” He said he did not want to “prejudice the best possible relations with a very important friend and neighbour but I’ve got to say that we can’t just ignore this kind of thing if the perfectly reasonable representations we are making to Indonesia are ignored by them”.
(20) March 2009 Butler is convicted of grievous bodily harm and sentenced to 19 months in prison.