What's the difference between agonizing and groanful?
Agonizing
Definition:
(p. pr. & vb. n.) of Agonize
Example Sentences:
(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Groanful
Definition:
(a.) Agonizing; sad.
Example Sentences:
(1) For the final three visible minutes, Lockett writhed, groaned, attempted to lift himself off the gurney and tried to speak, despite a doctor having declared him unconscious.
(2) If I give a conference here, people groan when I talk about him.
(3) Of the Iraqi people, groaning under years of dictatorship.
(4) We meet at the headquarters of the Independent and the Evening Standard in Kensington, in an office scented by a Jo Malone orange blossom candle, and groaning with contemporary art.
(5) Clippard gets ahead of him 0-2, throws a high fastball which Carpenter refuses to chase and then takes two more balls to the collective groan of Nationals Park.
(6) Despite the world-weary tone of a brutal review in the New York Times, which suggested that it added nothing new to the "groaning shelf" of homosexual literature, a story with an unashamedly gay protagonist unleashed a storm of protest in a country where sodomy was still illegal.
(7) It's the first interview he's done since his marriage and divorce and the split-up of the Ordinary Boys, and it all comes rushing out in a spate, a tangle of chronological confusions and jokes, and groans when I quote some of his old interviews back at him, and statements of contrition, and digressions about Dawkins or whatever, and here's the confounding thing - he's really nothing like I was expecting, not indie-boy sulky, or attempting to play it cool, he's just talkative and engaging, and he has a sense of humour about himself that, from reading his previous interviews, I wouldn't have even guessed at.
(8) Not all the jokes land, and some of the tastelessness may inspire groans.
(9) A s the schools break up for summer, the shelves of Britain’s retailers are groaning with “half price” sun protection cream offers, ready for families heading to the beach.
(10) The retired appeal court judge's report, which runs to three volumes, found that troops from 1st Battalion Queen's Lancashire Regiment inflicted "gratuitous" violence on a group of 10 Iraqi civilians, who were kicked and hit in turn, "causing them to emit groans and other noises and thereby playing them like musical instruments".
(11) "Oh God," groaned a delegate leafing through the guide to fringe meetings.
(12) There were groans as Clinton was declared victorious, although there was also defiance.
(13) Read more The MEPs responded to his oration with a mixture of boos, groans, shouts and ironic applause.
(14) The family justice review speculates that the cost of the entire groaning, overloaded family court system – only likely to be exacerbated after Thursday's report into the death of another toddler, Ryan Lovell Hancox – could be in the region of £1.5bn.
(15) The home fans groaned whenever the ball went near the Romanian, Benteke often pulled away to the left to unsettle him, and Villa’s opener came after he conceded possession cheaply inside his own half.
(16) Meanwhile, New York and New Jersey groaned back to life after travel bans.
(17) "There's a stereotype of a groaning bodybuilding guy using the weights area," says McGown.
(18) I'd groan at gossip magazines, furious with the world's asinine obsession with celebrity, disappointed by women gazing doe-eyed at the camera with vulnerable, save-me expressions on their Botoxed faces.
(19) Between their inward groans and suppressed giggles, the friends recognised something of great value, a familiar form no other artist had yet nicked.
(20) I can think of many things, of whether we summon the strength to recognise the global challenge of the 21st century and beat it, of the Iraqi people groaning under years of dictatorship, of our armed forces - brave men and women of whom we can feel proud, whose morale is high and whose purpose is clear - of the institutions and alliances that shape our world for years to come.