What's the difference between agonizing and harrowing?

Agonizing


Definition:

  • (p. pr. & vb. n.) of Agonize

Example Sentences:

  • (1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
  • (2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
  • (3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
  • (4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
  • (5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
  • (6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
  • (7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
  • (8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
  • (9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
  • (10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
  • (11) In the inferior parietal cortex, agonal status confounded this comparison.
  • (12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
  • (13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
  • (14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
  • (15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
  • (16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
  • (17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
  • (18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
  • (19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
  • (20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.

Harrowing


Definition:

  • (p. pr. & vb. n.) of Harrow

Example Sentences:

  • (1) 7.13pm BST The starting XIs England: Hart (Oxford University), Walker (Barnes), Cahill (Harrow Chequers), Jagielka (Cambridge University), Baines (1st Surrey Rifles), Wilshere (Old Harrovians), Gerrard (Wanderers), Walcott (Swifts), Cleverley (Old Carthusians), Welbeck (Royal Engineers), Rooney (Old Etonians).
  • (2) A student who lost her leg in the Alton Towers rollercoaster crash says she has been given a new lease of life by a hi-tech prosthetic leg and that she is stronger for her harrowing experience.
  • (3) Arredondo's story appears equally dramatic and harrowing.
  • (4) There are some deeply harrowing cases, a lot of people will be disclosing sexual violence and for many of them they won’t have told anyone else before.
  • (5) Police Scotland have confirmed that they will contact MP Michelle Thomson after she moved colleagues to tears in the Commons on Thursday when she revealed harrowing details of her rape at the age of 14 and its subsequent impact on her life.
  • (6) Copper levels were elevated to the normal range in both dietary groups of the Gujerati and were similar to the concentrations found in the Harrow groups.
  • (7) The inquest heard at times harrowing detail about how gangs of local teenagers and children, some as young as 10, had the family "under siege".
  • (8) Dietary intake of 813 pregnant Harrow Asians of mainly Gujarati descent was compared with the intake of 54 pregnant Europeans living in the same area.
  • (9) We would not wish any other families to go through this harrowing experience and appeal to everyone to keep calm and show their respect in a peaceful manner."
  • (10) An already grim night for United might have been even more harrowing if the referee, Martin Atkinson, had taken action against Marouane Fellaini for embedding his studs in the back of James McCarthy's leg.
  • (11) For Liverpool it has been a harrowing, valedictory year, the kind that deserves a send-off, and they had one here even in defeat.
  • (12) The trailer comprises a harrowing clip from the film in which the sniper must choose whether to gun down an Iraqi woman and child who appear to be mounting a suicide attack, interspersed with flashbacks to the soldier’s life in America with his own wife and children.
  • (13) Bosnia-Herzegovina Aligned to Eurovision's Balkan Bloc Harrowingly for Greece, there is a rival Balkan Bloc entry and hurrah, the song is in the local language.
  • (14) He said: “Among the horror of the refugee crisis, one of the most harrowing images has been the thousands of orphaned children fleeing conflict.” “Britain has always been a compassionate and welcoming country, and I am delighted that the government has finally, after months of pressure, committed to vital humanitarian aid.
  • (15) A high prevalence of iron deficiency was found in apparently healthy Asian immigrant children in Harrow.
  • (16) Perhaps the most harrowing part for Manchester City amid all the regrets and raw disappointment is the way large parts of this game seemed to pass them by.
  • (17) Some case notes make harrowing reading: cells occupied by disabled prisoners with no wall bars and inmates having to drag themselves across the floor and falling frequently; PAS "having to make a fuss" to get inmates supplied with basic needs, such as walking sticks, which are then taken away when a prisoner moves prison; and an incontinent prisoner with mental health problems sleeping naked on a urine-soaked mattress.
  • (18) Lorraine's life story reads like the harrowing epilogue to one of Dunbar's plays.
  • (19) Throughout this tournament, the striker with a bowl-cut straight out of Hull circa 1986 has lead the line superbly, made perceptive runs, found excellent scoring positions ... and squandered more opportunities than a boy who's been expelled from Eton, Harrow and every other fee-paying school in the land.
  • (20) The emir of Qatar , the world's richest country per capita, is poised to hand over power to his Harrow-educated son and heir in a rare peaceful transition for the tiny but globally influential Gulf state.