(1) The hypothesis that opiate agonism requires an N substituent in the axial position does not appear to be consistent with the increased potency of beta isomers in which axial N substituents are thermodynamically more unstable.
(2) Under conditions of 5-HT1-like, 5-HT2 and 5-HT3 receptor blockade, the following rank order of agonism was observed: 5-HT > 5-methoxytryptamine = renzapride > (S)-zacopride > (R,S-zacopride > 5-carboxamidotryptamine > BRL 24682 > (R-zacopride > metoclopramide > 2-methyl-5-HT > sulpiride.
(3) At the agonal stage, the isoproterenol dose-response curve was shifted significantly to the right in myocardial membranes from endotoxic rats, but there was no significant decrease in maximum stimulated activity.
(4) Agonal state effects the stability of brain compounds and causes brain hypoxia.
(5) However, further studies showed compounds which exhibited either partial agonism in the RFA and competitive antagonism of 5-HT in the RA, or antagonism of 5-HT in both arteries with different affinities.
(6) Catecholamines were detectable in the major neurons, in small intensely fluorescent cells, and in adrenergic fibers with varicosities at levels that varied with the patient's age, cause of death, duration of the agonal period, the treatment administered, and the time when the material had been taken after death.
(7) Certain derivatives of the antagonists naloxone and naltrexone showed partial agonism.
(8) Except for desGly(NH2)AVP, which is a weak V2 agonist, the remaining desGly and desGly(NH2) analogues of 1-3 exhibit substantial V2 agonism and are thus highly selective V2 agonists.
(9) But bureaucratic dysfunction means less than half have been given out – as shown by two state department charts – and only at the end of agonizingly long waiting periods .
(10) The results failed to support the female agonism hypothesis and indicate a need for more detailed studies of intermale social dynamics.
(11) In the inferior parietal cortex, agonal status confounded this comparison.
(12) Dilevalol is a novel antihypertensive agent combining vasodilation due to selective beta 2-adrenergic receptor agonism with nonspecific beta antagonism.
(13) The results indicate that alpha 2-adrenergic agonism with clonidine inhibits the bronchoconstriction induced by histamine.
(14) We have found no evidence of a physiologically relevant effect of serotonin agonism on osmoregulated vasopressin release, or on the ability of normal man to excrete a water load.
(15) The partial agonism of N alpha-guanylhistamine is related to the ability of the drug to bind with the receptor in two different modes with similar affinity.
(16) In contrast U50,488H produced biphasic curves characterized by a higher potency phase of agonism that was susceptible to antagonism by 16-methylcyprenorphine (RX8008M) and a lower potency phase that was apparently non-opioid in nature.
(17) As this profile of activity is not shared by the shorter-acting compound, salbutamol, it would seem that anti-inflammatory activity is associated with beta-adrenoceptor agonism of long duration.
(18) To clarify the regulation of duodenal motility, the aim of the present study was to investigate the effects of alpha-adrenoceptor agonism and blockade and of galanin on duodenal motility.
(19) Agonist-independent pA2 estimates for ICS 205-930 (6.3-6.6) suggest a single site of agonism.
(20) In addition, analyses of beta-adrenoceptor agonism and antagonism, using selective (beta 1: T-1583, beta 2: procaterol) and non-selective (isoproterenol) agonists as well as selective (beta 1: atenolol, beta 2: ICI 118,551) and non-selective (propranolol) antagonists, confirmed that beta-adrenoceptors in the canine facial vein are not homogeneous, with the beta 1-subtype predominating over the beta 2-subtype, and that the canine saphenous vein has a homogeneous population of the beta 2-subtype, as reported in the other species.
Torturous
Definition:
(a.) Involving, or pertaining to, torture.
Example Sentences:
(1) The denial of justice to victims of British torture, some of which Britain admits, is set to continue.
(2) Hayden had argued that the harsher interrogation techniques had provided valuable information and said that the techniques did not amount to torture.
(3) The court hearing – in a case of the kind likely to be heard in secret if the government's justice and security bill is passed – was requested by the law firm Leigh Day and the legal charity Reprieve, acting for Serdar Mohammed, tortured by the Afghan security services after being transferred to their custody by UK forces.
(4) "Consider this, all six or so hours of his Champions League finals would have been torture."
(5) Lastly, sexually tortured women manifest greater psychological and sexual dysfunction.
(6) The government also faced considerable international political pressure, with the United Nations' special rapporteur on torture, Juan Méndez, calling publicly on the government to "provide full redress to the victims, including fair and adequate compensation", and writing privately to David Cameron, along with two former special rapporteurs, to warn that the government's position was undermining its moral authority across the world.
(7) And it means the Foreign Office dealing with those in the Middle East and North Africa who are on the side of democracy and human rights, not sitting down to tea with torturers.
(8) In a 2012 study submitted to the UN, the Petersburg-based centre alleged that Roma and migrants were routinely subjected to police torture .
(9) His torturous journey for a safer life has led to no life .
(10) The day it opened in the US, three senators – senate select committee on intelligence chairwoman Dianne Feinstein, Carl Levin and John McCain – released a letter of protest to Sony Pictures's CEO, citing their committee's 6,000-page classified report on interrogation tactics and calling on him "to state that the role of torture in the hunt for Osama bin Laden is not based on the facts, but rather part of the film's fictional narrative".
(11) But under his government the security forces killed more than 2,000 people, and an estimated 25,000 people were detained without trial and often tortured.
(12) Limits are a relief, because they concentrate the drama and free the writer from the torture of choice, as Aristotle knew when he advised playwrights to preserve "the unities" by telling one story in one place over a single day.
(13) Sometimes the way the MP [military policeman] holds the head chokes me, and with all the nerves in the nose the tube passing the nose is like torture,” Dhiab said in a legal filing.
(14) Diego Garcia guards its secrets even as the truth on CIA torture emerges Read more The long-awaited decision – expected to cause enormous disappointment – follows more than 40 years of campaigning, court cases and calls for the UK to right a wrong committed by Harold Wilson’s Labour government.
(15) In his letter Abd El Fattah highlights the arbitrary nature of many of their detentions, the torture to which thousands have probably been subjected – and the apathy towards, and often enthusiasm for, such malpractice among the public.
(16) The consequences for Syria have been multiple massacres, ethnic cleansing, torture, a humanitarian crisis and the risk of the country's breakup.
(17) While ruling that there had been improper use of Schedule 7 powers, the judge commented: "It was clear that the Security Service, for entirely understandable reasons, was anxious if possible to get information which could not be regarded as tainted by torture allegations or which might confirm the propriety of a control order."
(18) All the personality, dignity and humanity of a person are devastated by this torture.
(19) You had to let it crash over you.” Facebook Twitter Pinterest ‘Miles’s life was torture’ … Lu Spinney at home.
(20) Davis said he would be surprised if an incoming Conservative government did not set up an immediate inquiry into this case and others where Britain is alleged to have been involved in the secret rendering by the US of detainees to prison where they were likely to be tortured.