(n.) Pain so extreme as to cause writhing or contortions of the body, similar to those made in the athletic contests in Greece; and hence, extreme pain of mind or body; anguish; paroxysm of grief; specifically, the sufferings of Christ in the garden of Gethsemane.
(n.) Paroxysm of joy; keen emotion.
(n.) The last struggle of life; death struggle.
Example Sentences:
(1) "The new feminine ideal is of egg-smooth perfection from hairline to toes," she writes, describing the exquisite agony of having her fingers, arms, back, buttocks and nostrils waxed.
(2) It has been awfully hard-won, carved slowly out of a big block of human agony.
(3) Her agony and her rapture stay interior, and they flip-flop like nerves in this beautiful, grave black-and-white movie.
(4) Those who remember the Two Davids of the 1987 SDP-Liberal Alliance will recall the exquisite agony only too well, cruelly captured by the Spitting Image puppet of little Steel perched in big Owen's pocket.
(5) Using male and female Wistar rats, pituitary response to cardiac and respiratory failure type (CFT and RFT) sudden death caused by the intravenous administration of KC1 and SCC, respectively, was examined by analyzing variation in pituitary immunoreactive beta-endorphin (IR-beta-EP) levels determined by radioimmunoassay after death and in circulating IR-beta-EP levels during periods of agony.
(6) I was in the surgical ward at Westmorland General Hospital on Kendal Green, and it was agony.
(7) I'd go after work and he'd paint till 1 or 1.30 in the morning, and it was agony lying there on the floor.
(8) Evidently fuelled by the agony of losing a series twelve months ago when the trophy was almost within their grasp, they also had the teamwork, technique and experience to turn their quest for revenge into a reality.
(9) Facebook Twitter Pinterest Even those who’ve never seen a downhill ski race couldn’t help but sympathise with Bode Miller’s agony at missing out on a medal in what will surely be the last Olympic event of his career.
(10) "When the disaster was big enough," King writes, "agony and violent death had an enriching quality."
(11) Even at UCH, when no one was there for us and my father, having not slept for almost 30 hours, was pulling his hair out in agony, I tried to look at it all as a kind of comedy of errors."
(12) They were subject, of course, to the prison censor, but the agony over Winnie, and the passion of which that agony was a product, blazes through them.
(13) That he ended up in the dock in The Hague at all surprised many who have studied the man and his country's agony through the 1990s.
(14) Shawcross, however, maintains there was no bad intent and said for that reason he has not been tormenting himself about the moment he collided with Ramsey's right leg and left the teenager writhing in agony.
(15) He notes the uneven agony - 80% will land in developing countries.
(16) The poor animals are thrown back into the water to die in agony, a practice condemned by environmental campaigners.
(17) The rest was pure agony for the Australians, give or take a yellow card for Sonny Bill Williams, given for a dangerous tackle.
(18) The woman before you in agony pushing and pushing, losing all dignity, does not care one bit whether I am feeling alarmed at her screaming, worried about where I should be standing, wondering whether I should rub her back or try and make small talk between contractions.
(19) Litvinenko sipped “three or four times” from a cup of radioactive tea, and died in agony 23 days later, the inquiry heard last week.
(20) Our most excruciating agony is of not being noticed in the world.
Antagonist
Definition:
(n.) One who contends with another, especially in combat; an adversary; an opponent.
(n.) A muscle which acts in opposition to another; as a flexor, which bends a part, is the antagonist of an extensor, which extends it.
(n.) A medicine which opposes the action of another medicine or of a poison when absorbed into the blood or tissues.
(a.) Antagonistic; opposing; counteracting; as, antagonist schools of philosophy.
Example Sentences:
(1) This death is also dependent on the presence of chloride and is prevented with the non-selective EAA antagonist, kynurenic acid, but is not prevented by QA.
(2) Microionophoretically applied excitatory amino acids induced firing of extracellularly recorded single units in a tissue slice preparation of the mouse cochlear nucleus, and the similarly applied antagonist 2-amino-5-phosphonovalerate (2APV) was demonstrated to be a selective N-methyl-D-aspartate (NMDA) receptor antagonist.
(3) Meanwhile the efficiency of muscarinic antagonists in inhibition of tremor reaction induced by arecoline administration is associated with interaction between the drugs and the M2-subtype.
(4) The anticonvulsant properties of the endogenous excitatory amino acid antagonist, kynurenic acid (KYA), were studied in prepubescent and adult rats using the amygdaloid kindling model of epilepsy.
(5) A novel bicyclic prostaglandin analogue, (1S)-[1 alpha,2 alpha(Z),3 alpha,4 alpha]-7-[3-[(hexylthio)methyl]-7- oxabicyclo [2.2.1]hept-2-yl]-5-heptenoic acid ((-)-10), and its cogeners were found to be potent antagonists at the TxA2 receptor.
(6) This difference was abolished by exposure of the slices to propranolol, a beta-adrenergic receptor antagonist.
(7) The TxA2 antagonistic effects of KW-3635 were compared with that of daltroban in PRP from various animals species.
(8) In experiments performed to determine whether PtdIns(4,5)P2 hydrolysis induced by TRH may have been caused by the elevation of [Ca2+]i, the following results were obtained: the effect of TRH to decrease the level of PtdIns(4,5)P2 was not reproduced by the calcium ionophore A23187 or by membrane depolarization with 50 mM K+; the calcium antagonist TMB-8 did not inhibit the TRH-induced decrease in PtdIns(4,5)P2; and, most importantly, inhibition by EGTA of the elevation of [Ca2+]i did not inhibit the TRH-induced decrease in PtdIns(4,5)P2.
(9) Similarly, 50 microM D-600, a Ca+2 channel antagonist, significantly (P less than 0.01) reduced basal and 5-HETE-induced PRL release.
(10) Selective removal of endothelium had no effect on BK-induced contraction or the action of the antagonists.
(11) The second experiments entailed use of the nonspecific opiate antagonist, naloxone, as well as the specific delta antagonist, ICI 154,129, against seizures induced by icv-administered morphine, morphiceptin, DADL, or DSLET.
(12) These antagonists reverse NMDA-mediated long term influence in these brain areas.
(13) This novel mechanism of receptor regulation, named transmodulation, should be distinguished from the reduction in total receptor number caused by the homologous ligand (downregulation) and from the change in affinity produced by the binding of agonists or antagonists to the same receptor site.
(14) Furthermore, the ability of a vasopressin antagonist to lower arterial pressure in NTS hypertensive rats was markedly attenuated by clonidine treatment.
(15) All of the serotonergic antagonists studied had additional effects on the response of the coronary artery to electrical stimulation or to norepinephrine.
(16) Their receptive fields comprise a temporally and spatially linear mechanism (center plus antagonistic surround) that responds to relatively low spatial frequency stimuli, and a temporally nonlinear mechanism, coextensive with the linear mechanism, that--though broad in extent--responds best to high spatial-frequency stimuli.
(17) The effects of low doses of dihydropyridine (DHP) calcium channel antagonists nimodipine, nifedipine, (-)-R-202-791, and amlodipine, the DHP calcium channel agonist BAY K 8644 were investigated on clonic convulsions to pentylenetetrazole (PTZ) in mice.
(18) Addition in the cultures of 4-deoxypyridoxine, a potent antagonist of vitamin B6 coenzymes, concurrently with the mitogen, inhibits the induction of serine hydroxymethyltransferase.
(19) These results suggest that prevention of xenograft rejection using PAF-antagonist in association with other methods should be further investigated.
(20) The high concentrations of gonadotropins present in immature female rats by the end of the second week of life were suppressed by treatment with an antagonist against luteinizing hormone-releasing hormone (LHRH-A; Org.