(1) Total cellular proteins from the livers of 4-, 16- and 52-week-old hepatitis- and hepatoma-predisposed Long-Evans Cinnamon (LEC) rats were compared to those from the livers of the corresponding control rats [Long-Evans Agouti (LEA) rats] by two-dimensional gel electrophoresis.
(2) Nonagouti rats were significantly easier to approach, capture, and handle than their agouti sibs.
(3) We have characterized a gene encoding a novel 131 amino acid protein that we propose is the one gene associated with the agouti locus.
(4) The cortical representation of the contralateral visual field in area 17 of the agouti's brain was studied by multiunit recording.
(5) Future experiments will determine the type of protein(s) encoded by the agouti coat color locus and establish the mechanism by which these protein(s) control the nature and timing of pigment production by melanocytes in the hair follicle.
(6) In a preliminary study, different rates of N-, O- and N,O- demethylation of dextromethorphan to yield D-methoxymorphinane, dextrorphan and D-hydroxymorphinane, respectively, were found in extensive- (Sprague-Dawley) and poor-metabolizer (female dark Agouti) rat strains.
(7) F1 hybrids of white gerbils with red eyes and agouti gerbils with wild coat color had the agouti coat color.
(8) When compared with dark Agouti rats treated with cremophore (n = 10) or not treated at all (n = 12), dark Agouti rats on chronic subcutaneous CsA plus cremophore for 23 days (n = 10) had no difference in kidney histology but had slightly increased liver fatty changes.
(9) The agouti (a) locus acts within the microenvironment of the hair follicle to regulate coat color pigmentation in the mouse.
(10) Tissues from lean agouti and obese yellow mice treated with HP in vitro showed decreased basal and insulin-stimulated glucose oxidation as well as decreased 14C incorporation into lipids.
(11) A breeding test disclosed chimerism of germ cells in two chimeric rats, and there were more pups with agouti coats than with albino coats.
(12) The Itp locus was mapped between the beta-2-microglobulin (B2m) and the agouti (a) loci on chromosome 2.
(13) We find that three different recessive lethal complementation groups are present at the agouti locus, two of which are contained within the al deletion.
(14) Unusual accumulations of Cu in the liver of LEC rats were found, depending on the age of the animals, the metal concentration being more than approximately 20-40 times those of normal LEA rats (Long-Evans rats with an agouti coat color).
(15) alpha-MSH and theophylline had no such effects on hair follicular tyrosinase activity in the non-agouti mice.
(16) Hematologic and serum chemical values established for the agouti were similar to those found in other rodents.
(17) They showed, for example, that the probability of the observed loss of the agouti color in the ATs being by chance is about 0.53 and the probability is nearly 0.50 for there being a spurious line difference, i.e., unrelated to ethanol sensitivity, in which only line had lost the agouti allele.
(18) We have also physically mapped these sequences by in situ hybridization to band H1 of chromosome 2, thus directly confirming previous assignments of the location of the agouti locus.
(19) Infant agoutis showed marginal antibody titers to reovirus type 3 and Toolan's H-1 viruses, and Theiler's GDVII antibodies were detected in juvenile agoutis, but no antibody titers to murine viruses were found in the adult agoutis maintained at our institution.
(20) The recombinants obtained provide valuable resources for determining the direction of chromosome walking experiments designed to clone sequences at the agouti locus.
Rat
Definition:
(n.) One of several species of small rodents of the genus Mus and allied genera, larger than mice, that infest houses, stores, and ships, especially the Norway, or brown, rat (M. decumanus), the black rat (M. rattus), and the roof rat (M. Alexandrinus). These were introduced into America from the Old World.
(n.) A round and tapering mass of hair, or similar material, used by women to support the puffs and rolls of their natural hair.
(n.) One who deserts his party or associates; hence, in the trades, one who works for lower wages than those prescribed by a trades union.
(v. i.) In English politics, to desert one's party from interested motives; to forsake one's associates for one's own advantage; in the trades, to work for less wages, or on other conditions, than those established by a trades union.
(v. i.) To catch or kill rats.
Example Sentences:
(1) All rats were examined in the conscious, unrestrained state 12 wk after induction of diabetes or acidified saline (pH 4.5) injection.
(2) It was tested for recovery and separation from other selenium moieties present in urine using both in vivo-labeled rat urine and human urine spiked with unlabeled TMSe.
(3) It is supposed that delta-sleep peptide along with other oligopeptides is one of the factors determining individual animal resistance to emotional stress, which is supported by significant delta-sleep peptide increase in hypothalamus in stable rats.
(4) The microsomal preparations from untreated Syrian golden hamster livers exhibited higher activities of N-demethylation towards the macrolide antibiotics, erythromycin and troleandomycin, than those from untreated and phenobarbital-treated rats.
(5) Phospholipid methylation in human EGMs is distinctly different from that in rat EGMs (Hirata and Axelrod 1980) in that the human activity is not Mg++-dependent, and apparent methyltransferase I activity is located in the external membrane surface.
(6) Biochemical, immunocytochemical and histochemical methods were used to study the effect of chronic acetazolamide treatment on carbonic anhydrase (CA) isoenzymes in the rat kidney.
(7) In conclusion, in S-rats a glucose-stimulated insulin release is accompanied by an increase in IBF, but this is not observed in P-rats.
(8) Competition with the labelled 10B12 MAb for binding to the purified antigen was demonstrated in sera of tumor-bearing and immune rats.
(9) Nutritionally rehabilitated animals had similar numbers of nucleoli to control rats.
(10) This study examined the [3H]5-HT-releasing properties of 3,4-methylenedioxymethamphetamine (MDMA) and related agents, all of which cause significant release of [3H]5-HT from rat brain synaptosomes.
(11) Addition of phospholipase A2 from Vipera russelli venom led to a significant increase in the activity of guanylate cyclase in various rat organs.
(12) Spontaneous locomotor activity was lower in naloxone-infused rats on day 3 only.
(13) The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA.
(14) We have investigated a physiological role of endogenous insulin on exocrine pancreatic secretion stimulated by a liquid meal as well as exogenous secretin and cholecystokinin octapeptide (CCK-8) in conscious rats.
(15) The subcellular distribution of sialyltransferase and its product of action, sialic acid, was investigated in the undifferentiated cells of the rat intestinal crypts and compared with the pattern observed in the differentiated cells present in the surface epithelium.
(16) However, the groups often paused less and responded faster than individual rats working under identical conditions.
(17) After 55 days of unrestricted food availability the body weight of the neonatally deprived rats was approximately 15% lower than that of the controls.
(18) To examine the central nervous system regulation of duodenal bicarbonate secretion, an animal model was developed that allowed cerebroventricular and intravenous injections as well as collection of duodenal perfusates in awake, freely moving rats.
(19) In the present investigation we monitored the incorporation of [14C] from [U-14C]glucose into various rat brain glycolytic intermediates of conscious and pentobarbital-anesthetized animals.
(20) Gel filtration of the 40,000 rpm supernatant fraction of a homogenate of rat cerebral cortex on a Sepharose 6B column yielded two fractions: fraction II with the "Ca(2+) plus Mg(2+)-dependent" phosphodiesterase activity and fraction III containing its modulator.