(n.) An intermittent fever, attended by alternate cold and hot fits.
(n.) The cold fit or rigor of the intermittent fever; as, fever and ague.
(n.) A chill, or state of shaking, as with cold.
(v. t.) To strike with an ague, or with a cold fit.
(1) Aspartylglycosaminuria (AGU) is a hereditary metabolic disorder characterized by slowly progressive mental deterioration from infancy, urinary excretion of large amounts of aspartylglycosamine, and decreased activity of the lysosomal enzyme aspartylglcosamine amido hydrolase in various body tissues and fluids.
(2) Correlated morphological and biochemical studies thus definitely establish that AGU is a generalized storage disorder.
(3) Aspartylglucosaminuria (AGU) is a lysosomal storage disease due to mutations in the aspartylglucosaminidase (AGA) gene.
(4) The polymerase chain reaction was used to amplify the glycosylasparaginase protein coding sequence from the three AGU patients in order to compare them to the normal sequence from a full-length human placenta cDNA clone HPAsn.6 (Fisher, K.J., Tollersrud, O.K., and Aronson, N.N., Jr. (1990) FEBS Lett.
(5) The addition of Ser AGC AGU tRNA to an E. coli cell-free protein synthesizing system which contains the endogenous tRNA levels results in up to 100% of the ribosomes translating the MS2 coat gene shifting into the -1 reading frame.
(6) Thus, the high prevalence of AGU in the Finnish population is the consequence of a founder effect of one ancient mutation.
(7) When the 3' overlapping codon is AGA or AGG, there is no ribosome frameshifting; when it is AGU (read by the same serine tRNA) there is frameshifting, although less efficiently than in the case of AGC.
(8) The AGU would not respond directly to questions about the climate science town hall.
(9) One neutral and two acidic glycoasparagines were isolated from the urine of patients with aspartylglycosylaminuria (AGU).
(10) The truncated AGU protein was neither catalytically active nor processed into mature alpha and beta subunits.
(11) AGU patients had significantly reduced serum zinc concentrations.
(12) We conclude that the increased serum free dolichol in AGU reflects disturbed lysosomal function and that the decreased free and esterified dolichols in NCLs speak against their presumed primary lysosomal nature.
(13) In aspartylglycosaminuria (AGU), a lysosomal storage disorder of glycoprotein degradation, there are some abnormalities in collagen and proteoglycan metabolism.
(14) 80%) than those linked to a guanosine nucleoside through the same type of bond (AGU, AGG, AGC, ca.
(15) The major known glycosylasparaginase gene defect G488----C, which causes the lysosomal storage disease aspartylglycosaminuria (AGU) in Finland, is located in exon 4.
(16) This bacterium contains two isoacceptor threonine tRNAs having anticodon sequences AGU and UGU, both with unmodified first nucleotides.
(17) We have earlier reported a single missense mutation (Cys163----Ser) to be responsible for 98% of the AGU alleles in the isolated Finnish population, which contains about 90% of the reported AGU patients.
(18) (2) There are two tRNAThr species having anticodons UGU and AGU; the first positions of these anticodons are unmodified.
(19) The altered metabolism in AGU results from a deficiency of the enzyme aspartylglucosaminidase (1-aspartamido-beta-N-acetylglucosamine amidohydrolase), which hydrolyses the asparagine to N-acetylglucosamine linkages of glycoproteins and glycopeptides.
(20) Two base changes were found to be common to all three Finnish AGU patients, a G482----A transition that results in an Arg161----Gln substitution and a G488----C transversion that causes Cys163----Ser.
(n.) Air infected with some noxious substance capable of engendering disease; esp., an unhealthy exhalation from certain soils, as marshy or wet lands, producing fevers; miasma.
(n.) A morbid condition produced by exhalations from decaying vegetable matter in contact with moisture, giving rise to fever and ague and many other symptoms characterized by their tendency to recur at definite and usually uniform intervals.
(1) The rise of malaria despite of control measures involves several factors: the house spraying is no more accepted by a large percentage of house holders and the alternative larviciding has only a limited efficacy; the houses of American Indians have no walls to be sprayed; there is a continuous introduction of parasites by migrants.
(2) Eighty-two per cent of patients with falciparum malaria had recently returned from Africa whereas 82% with vivax malaria had visited Asia.
(3) 236 patients with malaria were examined and treated.
(4) But both for malaria and Aids we’re seeing the tools that will let us do 95-100% reduction.
(5) In assessing damaged nets and curtains it must be recognised that anything less than the best vector control may have no appreciable impact on holoendemic malaria.
(6) Since then the intensive development of anti-malaria campaigns in urban areas over about ten years led temporarily to a considerable decrease in the level of endemicity, while in rural areas it remained unchanged.
(7) On land, the pits' stagnant pools of water become breeding grounds for dengue fever and malaria.
(8) immunoglobulin, purified from the plasma of local semi-immune blood donors, as an adjunct to standard treatment for cerebral malaria in Malawian children.
(9) Treatment with chloroquine and primaquine, together with packed red cell transfusions, was successful in eliminating both the malaria parasites and the leukaemoid blood picture.
(10) These C+ and R+ adherence properties of PE appear to mediate much of the pathogenesis of severe malaria infections, in part by blocking blood flow in microvessels.
(11) There was less of an increase following a blood meal infected with the rodent malaria parasite, Plasmodium berghei.
(12) Clindamycin, a semi-synthetic antibiotic of the lincomycin family, at a dose of 450 mg eight-hourly for three days in adults cured five out of 10 patients moderately ill with chloroquine-resistant falciparum malaria.
(13) This test by virtue of its high sensitivity and the facilities in processing a large number of specimens, can prove to be useful in endemic areas for the recognition of asymptomatic malaria and screening of blood donors.
(14) A small clinic consisting of 1 room decorated with pamphlets against AIDS, malaria, and other diseases was managed by the chief primary health care (PHC) assistant named Joseph.
(15) Prospects for involvement in malaria control are numerous, however there is need to enhance the existing BHW Program.
(16) This latter event might be one of the factors which results in a correlation of Burkitt's lymphoma with malaria endemic regions.
(17) Hemoglobin S (Hb S) was significantly more prevalent in adults resistant to malaria.
(18) The proportion of persons with P. malariae in this sample population, as determined by slide examination, appears to be the greatest ever reported for any area before the introduction of control measures.
(19) Other causes are malaria (21), undernutrition (12), meningitidis (10), diarrhea (9), pneumopathy (7), endogenous and obstetrical causes (24).
(20) An indirect fluorescent antibody test for glutaraldehyde-fixed, ring-infected erythrocyte surface antigen was performed on admission sera from 45 patients with complicated cerebral Plasmodium falciparum malaria, 33 with uncomplicated cerebral malaria, 91 non-cerebral malaria patients, and 53 blood donors from a non-malarious area.