(n.) An intermittent fever, attended by alternate cold and hot fits.
(n.) The cold fit or rigor of the intermittent fever; as, fever and ague.
(n.) A chill, or state of shaking, as with cold.
(v. t.) To strike with an ague, or with a cold fit.
Example Sentences:
(1) Aspartylglycosaminuria (AGU) is a hereditary metabolic disorder characterized by slowly progressive mental deterioration from infancy, urinary excretion of large amounts of aspartylglycosamine, and decreased activity of the lysosomal enzyme aspartylglcosamine amido hydrolase in various body tissues and fluids.
(2) Correlated morphological and biochemical studies thus definitely establish that AGU is a generalized storage disorder.
(3) Aspartylglucosaminuria (AGU) is a lysosomal storage disease due to mutations in the aspartylglucosaminidase (AGA) gene.
(4) The polymerase chain reaction was used to amplify the glycosylasparaginase protein coding sequence from the three AGU patients in order to compare them to the normal sequence from a full-length human placenta cDNA clone HPAsn.6 (Fisher, K.J., Tollersrud, O.K., and Aronson, N.N., Jr. (1990) FEBS Lett.
(5) The addition of Ser AGC AGU tRNA to an E. coli cell-free protein synthesizing system which contains the endogenous tRNA levels results in up to 100% of the ribosomes translating the MS2 coat gene shifting into the -1 reading frame.
(6) Thus, the high prevalence of AGU in the Finnish population is the consequence of a founder effect of one ancient mutation.
(7) When the 3' overlapping codon is AGA or AGG, there is no ribosome frameshifting; when it is AGU (read by the same serine tRNA) there is frameshifting, although less efficiently than in the case of AGC.
(8) The AGU would not respond directly to questions about the climate science town hall.
(9) One neutral and two acidic glycoasparagines were isolated from the urine of patients with aspartylglycosylaminuria (AGU).
(10) The truncated AGU protein was neither catalytically active nor processed into mature alpha and beta subunits.
(11) AGU patients had significantly reduced serum zinc concentrations.
(12) We conclude that the increased serum free dolichol in AGU reflects disturbed lysosomal function and that the decreased free and esterified dolichols in NCLs speak against their presumed primary lysosomal nature.
(13) In aspartylglycosaminuria (AGU), a lysosomal storage disorder of glycoprotein degradation, there are some abnormalities in collagen and proteoglycan metabolism.
(14) 80%) than those linked to a guanosine nucleoside through the same type of bond (AGU, AGG, AGC, ca.
(15) The major known glycosylasparaginase gene defect G488----C, which causes the lysosomal storage disease aspartylglycosaminuria (AGU) in Finland, is located in exon 4.
(16) This bacterium contains two isoacceptor threonine tRNAs having anticodon sequences AGU and UGU, both with unmodified first nucleotides.
(17) We have earlier reported a single missense mutation (Cys163----Ser) to be responsible for 98% of the AGU alleles in the isolated Finnish population, which contains about 90% of the reported AGU patients.
(18) (2) There are two tRNAThr species having anticodons UGU and AGU; the first positions of these anticodons are unmodified.
(19) The altered metabolism in AGU results from a deficiency of the enzyme aspartylglucosaminidase (1-aspartamido-beta-N-acetylglucosamine amidohydrolase), which hydrolyses the asparagine to N-acetylglucosamine linkages of glycoproteins and glycopeptides.
(20) Two base changes were found to be common to all three Finnish AGU patients, a G482----A transition that results in an Arg161----Gln substitution and a G488----C transversion that causes Cys163----Ser.
Rigor
Definition:
(n.) Rigidity; stiffness.
(n.) A sense of chilliness, with contraction of the skin; a convulsive shuddering or tremor, as in the chill preceding a fever.
(n.) The becoming stiff or rigid; the state of being rigid; rigidity; stiffness; hardness.
(n.) See 1st Rigor, 2.
(n.) Severity of climate or season; inclemency; as, the rigor of the storm; the rigors of winter.
(n.) Stiffness of opinion or temper; rugged sternness; hardness; relentless severity; hard-heartedness; cruelty.
(n.) Exactness without allowance, deviation, or indulgence; strictness; as, the rigor of criticism; to execute a law with rigor; to enforce moral duties with rigor; -- opposed to lenity.
(n.) Severity of life; austerity; voluntary submission to pain, abstinence, or mortification.
(n.) Violence; force; fury.
Example Sentences:
(1) He added: "There is a rigorous review process of applications submitted by the executive branch, spearheaded initially by five judicial branch lawyers who are national security experts and then by the judges, to ensure that the court's authorizations comport with what the applicable statutes authorize."
(2) Upon depletion of ATP in contraction, the P2 intensity reverted to the original rigor level, accompanied by development of rigor tension.
(3) which suggest that ~60-90% of the cross-bridges attached in rigor are attached in relaxed fibers at an ionic strength of 20 mM and ~2-10% of this number of cross-bridges are attached in a relaxed fiber at an ionic strength of 170 mM.
(4) The symptoms were successfully controlled by rigorous dietary measures.
(5) Rigorously designed clinical trials have demonstrated the efficacy and safety of fluoxetine in adults with major depressive disorder and obsessive-compulsive disorder (OCD) but not in patients below 18 years old.
(6) Unambiguous mapping and rigorous determination of the nature of the initiation triplet for IF2 beta, the smaller form of IF2, is critical for future mutagenesis of this codon, required for investigating the biological importance of both IF2 alpha and IF2 beta.
(7) The identification of the cDNA for an A2b-adenosine receptor will allow more rigorous characterization of its anatomical distribution and functional properties.
(8) Meanwhile, we need to show that the recent changes to how we work with the BBC Executive are allowing us to be more focused, more rigorous and more transparent in the work that we do, so that licence fee payers can get a better BBC.
(9) A village will be subject to rigorous evaluations in order to demonstrate sustainability and scalability, and that aid developed with an exit strategy can actually work.
(10) We therefore conclude that in postrigor muscles, paratropomyosin is released from the A-I junction region following the increase in the sarcoplasmic calcium ion concentration to 10(-4) M, and then binds to thin filaments, which results in weakening of rigor linkages formed between actin and myosin.
(11) New observations include: (1) In 15 nm cross sections that show single 14.5 nm levels: (a) The flared X structure characteristic of rigor is replaced by a straight-X figure in which the crossbridge density is aligned along the myosin-actin plane, rather than skewed across it as in rigor.
(12) Ferguson’s influence at Old Trafford has clearly waned since the Moyes appointment but, notably, there is no admission on his part that he chose the wrong man, insisting that the club followed a rigorous and methodical selection process.
(13) After a three-month period of rigorous training, two PAs were assigned to the ICU.
(14) Over the last few days a former member of parliament's intelligence and security committee, Lord King, a former director of GCHQ, Sir David Omand, and a former director general of MI5, Dame Stella Rimington, have questioned whether the agencies need to be more transparent and accept more rigorous scrutiny of their work.
(15) Even when carried out rigorously, culling does very little to help.
(16) Because the rigor of the present day "scientific method" demands clearcut and reproducible results and investigations require predictable performance of the parasite in an evenly maintained host that is in a highly constrained environment, we should not wonder why we cannot produce the events of nature.
(17) The best definition of osteoarthritis is anatomical, but to be rigorous must include the biochemical characteristics of osteoarthritis cartilage.
(18) "We remain committed to sourcing merchandise that is produced responsibly by suppliers that adhere to Walmart's rigorous Standards for Suppliers code of conduct."
(19) Edelman has a rigorous in-house carbon accounting system.
(20) Material, obtained by a rigorous three-stage sampling procedure from five normal rat livers, is systematically subjected to this analysis at four levels of magnification.