(v. t.) To affect with pain or uneasiness, either physical or mental; to trouble; to be the matter with; -- used to express some uneasiness or affection, whose cause is unknown; as, what ails the man? I know not what ails him.
(v. i.) To be affected with pain or uneasiness of any sort; to be ill or indisposed or in trouble.
(n.) Indisposition or morbid affection.
Example Sentences:
(1) Describing the Standard as a "good paper", he said his "social mission" was to help the ailing title survive.
(2) According to articles presented by Breitbart, Clinton is tired and ailing.
(3) Kelly reportedly spoke with lawyers investigating claims of sexual harassment by former Fox chairman Roger Ailes, who left the network following allegations by several women of years of abuse.
(4) The principle’s not so different now.” Fifteen years ago, when he was 27, Baker found himself with an ailing father and 250 cows, farmed traditionally – grass in summer, silage and concentrates in winter – around the village.
(5) Bill Gates betrayed his ailing business partner and tried to deprive him of his share of the Microsoft fortune, according to a scathing memoir from Paul Allen , the company's billionaire co-founder.
(6) If there's one thing this current Lakers squad, mostly assembled by Jerry Buss's son Jim while his father was ailing, has proven, it's that simply acquiring the best available players isn't enough to create a winning team, let alone a championship-caliber one.
(7) Almost all of the 20-plus women claim they experienced Ailes’s harassment firsthand.
(8) In addition, these studies reveal that functional homology exists between Ail and the structurally related protein Rck, which promotes resistance to complement killing in Salmonella typhimurium.
(9) Seven of these changes are predicted to be in cell surface domains of the protein (a model for the proposed folding of Ail within the outer membrane is presented).
(10) Hague has contacted Shaker Aamer to reassure him that attempts to reunite him with his family in London are continuing, a process made increasingly urgent by fresh evidence of the 44-year-old's ailing health.
(11) A chance to revive the fortunes of an ailing giant might just appeal to a man of his talents and ego.
(12) This week his criticism of Kelly – and thus a reported “feud” with the influential Fox News chief Roger Ailes – flared up again when Trump retweeted a message that called Kelly a “bimbo”.
(13) Paddle on the Riviera Facebook Twitter Pinterest Photograph: Alamy A half-hour walk from the tiny railway station at Cap d’Ail in the Alpes-Maritimes, a coastal footpath runs underneath a line of art nouveau and art deco villas and round a headland before Mala Plage comes into view.
(14) Roginsky said in the suit that she was punished for not disparaging the former Fox News host Gretchen Carlson after she filed a sexual harassment suit against Ailes.
(15) Joe Muto, Slate The Newsroom can be read as Sorkin's attempt to cure what's ailing the news industry, but he's misdiagnosing the patient.
(16) Anyone expecting the public to suddenly turn on Ailes in a way it hasn’t before is likely to be disappointed, Tyndall said, adding that part of Fox News’s classic-TV appeal is a re-creation of the permissive atmosphere that has historically made life unbearable for women in entertainment.
(17) I think you and I should have had a sexual relationship a long time ago and then you’d be good and better and I’d be good and better,” Ailes said, according to the lawsuit.
(18) However, the ailing Greek economy, which is suffering from an unemployment level twice as high as it was in May 2010 and industrial production 30% below to its pre-crisis level, has few ways to generate income without the EU’s support.
(19) Polymerase chain reaction was performed by using a mixture of primers against the inv gene from Y. pseudotuberculosis and the ail gene from pathogenic Y. enterocolitica.
(20) Lost time rate of long ailing persons was three times higher than that in the whole group, while lost time rate among frequently ailing persons was 2.5 times higher that than for the whole group.
Til
Definition:
(prep. & conj.) See Till.
Example Sentences:
(1) Analysis of lymphocyte subsets by flow cytometry demonstrated Leu 4, 43.6% (T cells); Leu 10, 10.5% (B cells) and Leu 7, 13.1% (natural killer (NK) cells) in TIL.
(2) With one exception none of the purified CD4+ or CD8+ TILs expressed any significant levels of CD56, while the unseparated TILs contained varying numbers of CD3+CD56+ and CD3-CD56+ populations.
(3) Furthermore, it was also confirmed that TIL-LAK cells could be induced in autochthonous mouse tumor systems and human gastric tumor systems.
(4) However, IL-4 did not alter the cytotoxic activity of TILs against autologous tumor cells and established tumor cell lines.
(5) I'm here to defend her 'til the end even if they put me in jail."
(6) PFP immunoreactivity in human peripheral blood lymphocytes (PBL) and tumour infiltrating lymphocytes (TIL) was investigated immunocytochemically with the aid of an anti-PFP monoclonal antibody.
(7) TIL grown in the presence of IL-4 significantly reduced the level of non-specific, non-major histocompatibility complex-restricted antitumor activity (P < 0.01 for allogeneic renal, nonrenal, and NK-sensitive K562 cells), while exhibiting no effect on the level of autologous killing.
(8) In contrast, immune T cells (including some TIL) are MHC-restricted, act under the direction of memory cells and lyse target cells primarily but not exclusively by the release of lymphotoxin (TNF beta) causing programmed cell death (apoptosis) through endonuclease activation and target cell DNA fragmentation.
(9) Much has been learned about TIL biology and their functional characteristics recently, but only few clinical trials have been completed to date.
(10) Tumor-infiltrating lymphocytes (TIL) from human pulmonary tumors have been studied as a model for local depression of cell-mediated immunity at the tumor site.
(11) Phenotypic analysis of expanded TIL and two clones further analyzed in more detail showed CD3+, CD4+, CD8-, and 2H4+ (CD45R+) expression.
(12) The studies demonstrate the feasibility of TILs as suitable cellular vehicles for the introduction of therapeutic genes into patients receiving autologous TILs.
(13) High levels of activity were exhibited by TIL against both P815, which is resistant to natural killer (NK) cells, and to NK-sensitive YAC-1 cells.
(14) To improve the potency of TILs, new cytokines with T-cell stimulatory effects used alone or in combination with interleukin-2 (IL-2) are currently being investigated.
(15) On the other hand, TIL derived from the 2 patients whose melanoma cell lines had lost expression of HLA-A2 had a predominant CD4 phenotype and virtually no cytotoxic activity.
(16) These observations may imply the possibility of adoptive immunotherapy using TIL against human primary liver tumors.
(17) Titration of K562 targets in a 51Cr release assay revealed that untreated TIL have low cytotoxicity (4.32%) compared to untreated PBL (34.3%, P = less than 0.001).
(18) Dominant rearrangements of T-cell receptor (TCR) beta-chain genes are reported among tumor-infiltrating lymphocytes (TIL).
(19) This augmentation of TIL-mediated antitumor activity was dependent on the dose of radiation used.
(20) Those TIL expressing activation antigens were CD2+, SIg-.