(interj.) An exclamation expressive of sorrow, pity, or apprehension of evil; -- in old writers, sometimes followed by day or white; alas the day, like alack a day, or alas the white.
Example Sentences:
(1) No difference in therapeutic activity between CNC-ala-17-E2 and CNC-ala could be observed in a transplanted rat leukemia (L 5222).
(2) In each subject, the activity in leucocytes of delta-aminolaevulinic acid (ALA) synthase increased and that of protoporphyrinogen (proto) oxidase decreased during the first week of therapy.
(3) The IL-8 isolated from each of these cell types is a mixture of two IL-8 polypeptides, one consisting of 72 amino acids (herein called [ser-IL-8]72) and the other 77 amino acids (an N-terminal extended form herein called [ala-IL-8]77).
(4) Two EGZ-derived proteins were engineered in which either His98 or Glu133 amino acid was converted to an Ala residue.
(5) In cirrhosis there was a decrease, of zinc (-40%) albumin (-38%) and of activity of ALA D (-48%) and an increase in blood lead (+80%).
(6) We have named them bombolitin I (Ile-Lys-Ile-Thr-Thr-Met-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin II (Ser-Lys-Ile-Thr-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin III (Ile-Lys-Ile-Met-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin IV (Ile-Asn-Ile-Lys-Asp-Ile-Leu-Ala-Lys-Leu-Val-Lys-Val-Leu-Gly-His-Val-NH2 ), and bombolitin V (Ile-Asn-Val-Leu-Gly-Ile-Leu-Gly-Leu-Leu-Gly-Lys-Ala-Leu-Ser-His-Leu-NH2 ).
(7) To confirm this, ALA-S activity was then directly measured in intact reticulocytes, and it was shown that ethanol indeed inhibited its activity.
(8) All inhibitors had no effect on L-Ala uptake into brush-border membrane vesicles in presence of Na+ gradient.
(9) Specimens from the bone marrow taken were by trephine biopsy from the sternum, ala ossis ilii and spine.
(10) Paraproteins, usually of the IgG-kappa isotype, were found in the sera of a significant number of HIV-1-infected individuals as were antibodies to lymphocytes (ALAs).
(11) With the use of the method Chick Embryotoxicity Screening Test II (CHEST II), the potential neuropeptides L-prolyl-L-leucyl-glycinamide (MIF), cyclo(1-aminocyclo-pentanecarbonyl-L-alanyl)[cyclo(Acp-Ala)] and cyclo(glycyl-L-leucyl)[Cyclo(Gly-Leu)] were tested in the critical developmental periods of d 1.5 to 4 of chick embryogenesis in order to objectively examine their undesirable interactions with the developing morphogenetic systems of the brain, eye, face, body wall, limbs, trunk and heart.
(12) The differential scanning calorimetry (DSC) studies demonstrate an increased susceptibility of the Ala 183----Pro mutant to thermal denaturation.
(13) Mutants of Escherichia coli which require 5-aminolaevulinic acid (5-ALA), the first intermediate of haem biosynthesis, do not respond to haemin and porphyrins.
(14) The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid sequence of human growth hormone, was studied.
(15) The replacements for Glu-43 (Asp, Gln, Asn, Ser, and Ala) both decreased the catalytic efficiency and changed the one- and two-dimensional NMR spectral properties of the mutant enzymes.
(16) Alas, for Jones, they found more of his ill-gotten gains in another plot he had perhaps forgotten to mention.
(17) The structures of two crystal forms of Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe have been determined.
(18) Daily intra-VTA injections of the mu opioid agonist Tyr-D-Ala-Gly-NMe-Phe-Gly-ol enhanced the behavioral stimulant effect of acute morphine.
(19) The (beta-chloro-, (beta, beta-dichloro-, and (beta, beta, beta-trichloro-alpha-aminoethyl)phosphonic acids have been synthesized and their inhibitory properties on the alanine racemases [EC 5.1.1.1] and the D-Ala:D-Ala ligases [EC 6.3.2.4] from Pseudomonas aeruginosa and Streptococcus faecalis have been evaluated.
(20) Angiotensin converting enzyme activity was measured in intact aortic rings utilizing the synthetic tripeptide [3H]-benzoyl-Phe-Ala-Pro as the substrate.
Sorrow
Definition:
(n.) The uneasiness or pain of mind which is produced by the loss of any good, real or supposed, or by diseappointment in the expectation of good; grief at having suffered or occasioned evil; regret; unhappiness; sadness.
(n.) To feel pain of mind in consequence of evil experienced, feared, or done; to grieve; to be sad; to be sorry.
Example Sentences:
(1) It came in a mix of joy and sorrow and brilliance under pressure, with one of the most remarkable things you will ever see on a basketball court in the biggest moment.
(2) Troh, a 54-year-old nursing assistant, issued a statement on Wednesday that said: “I trust a thorough examination will take place regarding all aspects of his care … I am now dealing with the sorrow and anger that his son was not able to see him before he died.” That appeared to be a reference to frustration at the hospital’s initial failure to diagnose him correctly, and a delay of several days before they treated him with experimental drugs.
(3) Goodman deceived us all, the witnesses sorrowfully admitted.
(4) Photograph: AP This is the moment of our deepest sorrow.
(5) Separately, in a Question Time-style debate at the Radio Festival today, Ofcom executive Stewart Purvis said he reacted "more in sorrow than anger" at yesterday's stinging attack on the regulator by former GMG Radio chief executive John Myers .
(6) 'This is not the justice we seek': sorrow in Baltimore as grief turns into riots Read more The city has improved significantly in recent years – crime dropped, the economy improved, the population stopped declining for the first time in 60 years – but you couldn’t see Baltimore’s newfound prosperity in Freddie Gray’s backyard, or in the gardens nearby.
(7) But at this moment of the final parting, my heart is heavy with sorrow and grief.” On death: “There is an end to everything and I want mine to come as quickly and painlessly as possible, not with me incapacitated, half in coma in bed and with a tube going into my nostrils and down to my stomach.” “Even from my sickbed, even if you are going to lower me to the grave and I feel that something is going wrong, I will get up.
(8) Time to listen to ‘World in Motion’ on loop while drowning a million sweet sorrows.
(9) Shara Proctor, who might have had hopes of gold while Okagbare busied herself with the 200m, managed only two steps of a run-up before clutching at her left thigh and leaving the arena with her hoodie pulled sorrowfully around her face.
(10) Prayer has comforted us in sorrow, and will help strengthen us for the journey ahead.
(11) "Would all these girls," he asks, with a sorrow that defies any glib, one-should-be-so-lucky retort, "be fucking me if they weren't getting paid?"
(12) I have immense sorrow over the loss of that child but I also have immense joy when I think of her.
(13) More than a dozen times in his presidency, Barack Obama has appeared before television cameras and issued statements to express sorrow at a mass shooting event in America.
(14) The emotion called chronic sorrow, introduced in 1962 by Olshansky, has had limited exposure in the literature.
(15) Yet the Brazilians who were photographed unleashing their sorrow on a cloudy, darkening evening, in scenes of anguish from Estádio Mineirão to Copacabana beach, were not mourning a massacre, atrocity or anything else that might seem to justify such infinite sadness.
(16) This too, I recognise, is another coping strategy, a way to get through what could be a sorrowful few years or even decades ahead.
(17) Every day I spend in sorrow, thinking about my family and how to reach the UK.” Intelligent, and very motivated, he is particularly frustrated at not being to able to study; eventually he hopes to become a doctor.
(18) For my own part, I would like to express sorrow and regret to those most distressed by the actions of my predecessor.
(19) American viewers mourning the death of Dan Stevens' character Matthew Crawley at the end of the show's Christmas special will be able to drown their sorrows with Downton wine, wear Downton jewellery and grow Downton roses, as part of a merchandising push aimed at capitalising on the drama's phenomenal global success.
(20) The concert has been long prepared, Josh and his friend Ahmed from the perilous estates nearby laying tracks to "Jessie Wright" and another song for Agnes – "a tribute to a girl got shot in Hoxton", Josh says, with apparent nonchalance, but a stab of sorrowful anger in his eye.