(interj.) An exclamation expressive of sorrow, pity, or apprehension of evil; -- in old writers, sometimes followed by day or white; alas the day, like alack a day, or alas the white.
Example Sentences:
(1) No difference in therapeutic activity between CNC-ala-17-E2 and CNC-ala could be observed in a transplanted rat leukemia (L 5222).
(2) In each subject, the activity in leucocytes of delta-aminolaevulinic acid (ALA) synthase increased and that of protoporphyrinogen (proto) oxidase decreased during the first week of therapy.
(3) The IL-8 isolated from each of these cell types is a mixture of two IL-8 polypeptides, one consisting of 72 amino acids (herein called [ser-IL-8]72) and the other 77 amino acids (an N-terminal extended form herein called [ala-IL-8]77).
(4) Two EGZ-derived proteins were engineered in which either His98 or Glu133 amino acid was converted to an Ala residue.
(5) In cirrhosis there was a decrease, of zinc (-40%) albumin (-38%) and of activity of ALA D (-48%) and an increase in blood lead (+80%).
(6) We have named them bombolitin I (Ile-Lys-Ile-Thr-Thr-Met-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin II (Ser-Lys-Ile-Thr-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin III (Ile-Lys-Ile-Met-Asp-Ile-Leu-Ala-Lys-Leu-Gly-Lys-Val-Leu-Ala-His-Val-NH2 ), bombolitin IV (Ile-Asn-Ile-Lys-Asp-Ile-Leu-Ala-Lys-Leu-Val-Lys-Val-Leu-Gly-His-Val-NH2 ), and bombolitin V (Ile-Asn-Val-Leu-Gly-Ile-Leu-Gly-Leu-Leu-Gly-Lys-Ala-Leu-Ser-His-Leu-NH2 ).
(7) To confirm this, ALA-S activity was then directly measured in intact reticulocytes, and it was shown that ethanol indeed inhibited its activity.
(8) All inhibitors had no effect on L-Ala uptake into brush-border membrane vesicles in presence of Na+ gradient.
(9) Specimens from the bone marrow taken were by trephine biopsy from the sternum, ala ossis ilii and spine.
(10) Paraproteins, usually of the IgG-kappa isotype, were found in the sera of a significant number of HIV-1-infected individuals as were antibodies to lymphocytes (ALAs).
(11) With the use of the method Chick Embryotoxicity Screening Test II (CHEST II), the potential neuropeptides L-prolyl-L-leucyl-glycinamide (MIF), cyclo(1-aminocyclo-pentanecarbonyl-L-alanyl)[cyclo(Acp-Ala)] and cyclo(glycyl-L-leucyl)[Cyclo(Gly-Leu)] were tested in the critical developmental periods of d 1.5 to 4 of chick embryogenesis in order to objectively examine their undesirable interactions with the developing morphogenetic systems of the brain, eye, face, body wall, limbs, trunk and heart.
(12) The differential scanning calorimetry (DSC) studies demonstrate an increased susceptibility of the Ala 183----Pro mutant to thermal denaturation.
(13) Mutants of Escherichia coli which require 5-aminolaevulinic acid (5-ALA), the first intermediate of haem biosynthesis, do not respond to haemin and porphyrins.
(14) The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid sequence of human growth hormone, was studied.
(15) The replacements for Glu-43 (Asp, Gln, Asn, Ser, and Ala) both decreased the catalytic efficiency and changed the one- and two-dimensional NMR spectral properties of the mutant enzymes.
(16) Alas, for Jones, they found more of his ill-gotten gains in another plot he had perhaps forgotten to mention.
(17) The structures of two crystal forms of Boc-Trp-Ile-Ala-Aib-Ile-Val-Aib-Leu-Aib-Pro-OMe have been determined.
(18) Daily intra-VTA injections of the mu opioid agonist Tyr-D-Ala-Gly-NMe-Phe-Gly-ol enhanced the behavioral stimulant effect of acute morphine.
(19) The (beta-chloro-, (beta, beta-dichloro-, and (beta, beta, beta-trichloro-alpha-aminoethyl)phosphonic acids have been synthesized and their inhibitory properties on the alanine racemases [EC 5.1.1.1] and the D-Ala:D-Ala ligases [EC 6.3.2.4] from Pseudomonas aeruginosa and Streptococcus faecalis have been evaluated.
(20) Angiotensin converting enzyme activity was measured in intact aortic rings utilizing the synthetic tripeptide [3H]-benzoyl-Phe-Ala-Pro as the substrate.
Woe
Definition:
(n.) A curse; a malediction.
(a.) Woeful; sorrowful.
(n.) Grief; sorrow; misery; heavy calamity.
Example Sentences:
(1) The disappointing weather at Easter left beaches deserted but some Britons, who were determined to enjoy the outdoors this time round, have already had their plans thwarted by the weather, taking to websites such as ukcampsite.co.uk to swap tales of woe, such as farmers calling to cancel bookings because sites were waterlogged.
(2) If I’m the bad guy because I’m not the guy they want me to be, then so be it.” Over the last year he resolved his promotional woes in court and has since signed with Jay Z’s Roc Nation Sports – along with Miguel Cotto the nascent sports agency’s highest-profile signing in boxing.
(3) While Chinese media have not spelt out Zhou's woes explicitly, the hints have grown more blatant by the month, with some identifying him via his family relationships.
(4) Asked if Aamer would talk publicly about his experiences, Crider said: “I think he will make up his own mind about it, and really, woe betide the person who tries to silence Shaker Aamer.” She added that it would be up to him “how much of his story and the terrible things he witnessed that he wants to tell”.
(5) Plummeting oil prices only added to economic woes in a country with the world’s fourth-largest oil reserves.
(6) To add to their woes, the cost of their dollar-denominated debt is rising; the US Federal Reserve said December’s rate hike is just the start of a “gradual” tightening cycle .
(7) It’s a seismic moment for the industry and particularly the big European manufacturers who have done a lot of work on diesel: technologically, they have they made the wrong bet.” Some analysts believe fears of brand damage in Europe are overstated but Bailey says: “In the US it’s very different: VW have killed their diesel market and it has left them in a very difficult position.” For British manufacturer Jaguar Land Rover, the timing of VW’s woes was ominous, as it unveiled two new diesels in America.
(8) The aluminium magnate's British-related woes do not stop there: a former business partner, Michael Cherney, is suing him for $4bn in the high court.
(9) We have to acknowledge that it's extremely hard to build a regular city from scratch.” Furthermore, some experts say that certified green buildings and pedestrian-friendly roads are a worthless patch for China’s environmental woes, not a solution.
(10) The woes of British industry were echoed right across Europe in November, as firms slashed production amid plunging demand from consumers in all the world's major markets.
(11) Clinton said her woes over her email server had been a “drip, drip, drip” that was impacting her.
(12) In an otherwise assured performance on Sunday’s Andrew Marr Show , Douglas Alexander – when urged to address Ed Miliband’s woes – resorted to the words of Harold Wilson.
(13) Buhari has presented himself as a born-again democrat who possesses the experience to steer the country through instability, currency woes and rampant corruption.
(14) Creative diplomacy is still much required in the Middle East, where it is hard to see how a dominantly military strategy against Islamic State can in itself, and even over time, bring a solution to the region’s woes.
(15) The unrest over rising petrol prices is only further adding to Nigeria's security woes: Jonathan already declared a state of emergency over the weekend in parts of the country hit by a growing Islamic insurgency that is fuelled in part by widespread poverty.
(16) But that may be the least of Ukip’s woes as it sups the bitter draught of victory.
(17) 7.31pm BST Nick Kyrgios's legs have gone to jelly and his heart is full of woe.
(18) It is not the cause of Spain's economic woes, but think of this: if everybody paid their dues, Spain's deficit would be zero.
(19) The result in some richer countries has been a political movement that blames globalisation for all woes and seeks somehow to wall off the economy from global trends rather than engage cooperatively with foreign nations.
(20) Probably... April 23, 2013 11.42am BST Analysts see little relief for Europe The continuing fall in Eurozone output this month ( see 9.19am ) led by Germany's shrinking private sector seconomy, shows that there's no improvement in Europe's woes.