(n.) An organic base, especially one of a class of substances occurring ready formed in the tissues of plants and the bodies of animals.
Example Sentences:
(1) Thus, alkaloid and insecticide modifications share many features but differ in how much the conducting properties of the pore are changed and whether the channel can close reversibly while the toxin remains bound.
(2) A clear structure-mutagenicity relationship was observed in a series of aporphine alkaloids (aporphine, dehydroaporphine, 7-oxoaporphine and 4,5-dioxoaporphine), and 10,11-non-substituted aporphines were suggested to exert their mutagenicity through metabolic activation of the 10,11 positions, possibly as the 10,11-epoxides.
(3) A radioactive, photoactive Vinca alkaloid, N-(p-azido-[3,5-3H]-benzoyl)-N'-beta-aminoethylvindesine [( 3H]NABV) with pharmacological and biological activities similar to vinblastine was synthesized and used to identify specific Vinca alkaloid macromolecular interactions in calf brain homogenate by photoaffinity labeling.
(4) The comparative metabolism of the pyrrolizidine alkaloid (PA) senecionine was studied in vitro in incubations of rat, guinea pig, cow, horse, and sheep hepatic microsomes.
(5) They also displayed negative correlation between activities of protein-inhibitors and the total content of protein and alkaloids.
(6) Methods have been reviewed for alkylating agents, platinum compounds, antitumour antibiotics, antimetabolites, alkaloids, suramin, 1-hydroxy-3-amino-propylidene-1,1-bisphosphonate and tamoxifen.
(7) The resistant strains exhibited cross resistance to anthracycline antibiotics, vinca alkaloids, actinomycin D, colchicine.
(8) In mice treated with cepharanthine (Cepha), a biscoclaurine alkaloid, the number of T cells was increased in the parathymic lymph nodes (PtLNs) which are considered to be the specialized lymph nodes in local differentiation of T cells.
(9) The alkaloid tubulosine inhibits the process of peptide chain elongation by eukaryotic polysomes by specifically preventing the elongation-factor-2-dependent step of translocation.
(10) Cultured roots of Stephania cepharantha, which are rich sources of bisbenzylisoquinoline alkaloids, were fed 14C-labelled tyrosine, tyramine or dopamine.
(11) As a possible mechanism underlying the alterations of DRP, the functional consequences of atrophic changes of primary central afferent terminals are being discussed in terms of the close correlation between structure and function and the possible inferences of the electrophysiological reaction to the therapeutic application of Vinca alkaloids in the iontophoretic treatment of chronic intractable pain.
(12) The poisonous principles in tansy ragwort are pyrrolizidine alkaloids, which cause gradual alteration and necrosis of liver cells with replacement by fibrous tissue.
(13) In this study, the roots of Tabernaemontana heyneana Wall were examined and the isolation and identification of additional indole alkaloids and some pharmacological properties of coronaridine are described.
(14) The area ratios of four alkaloids (tropacocaine, norcocaine, cis-cinnamoylcocaine, and trans-cinnamoylcocaine) to cocaine are calculated for each sample.
(15) The main drugs with specific action on migraine include ergot alkaloids (ergotamine, dihydroergotamine), agonists (sumatriptan) or partial agonists (methysergide) at a specific subtype of 5-HT1-like receptors, beta-adrenoceptor antagonists (propranolol, metoprolol), calcium antagonists (flunarizine) and anti-inflammatory agents (indomethacin).
(16) Effects of solution variables on the binding and self-association explain the wide variation of reported apparent binding constants for Vinca alkaloids to tubulin.
(17) The concomitance of five previously reported trans-2,5-dialkyl-pyrrolidines along with small amounts of the cis isomers and N-methyl analogues makes the venom of M. indicum the most qualitatively diverse blend of alkaloids reported from an ant to date.
(18) Strong enhancement of delayed-type hypersensitivity (DTH) was observed after treatment with the active cyclophosphamide (CY) derivative Z 7557 or the plant alkaloid VP-16 at the site of sensitization.
(19) A total alkaloid and two purified alkaloid extracts of Alangium Vitiense were revealed by our experimental screening to be oncostatic on L1210 leukemia and two other lymphoid neoplasias in Mice.
(20) Possible mechanisms underlying these effects of insecticides on alkaloid-dependent uptake are discussed in light of a qualitative model formulated from these results and previous biochemical and electrophysiological studies.
Opium
Definition:
(n.) The inspissated juice of the Papaver somniferum, or white poppy.
Example Sentences:
(1) The only entirely original stage work from this period was the spectacular one-man show Needles And Opium in 1991, which intermingled stories of love and addiction from the lives of Jean Cocteau and Miles Davis with an account of the meltdown of one of Lepage's own long-term relationships.
(2) Social changes going on in the society were reflected in choice of substance forms by younger people as compared to their elders (e.g., cigarettes vs pipes or cigars, heroin vs opium, manufactured vs village-produced alcohol).
(3) American frustrations burst into the open in October 2009 when serving and retired officials told the New York Times Karzai was a key player in Afghanistan's illegal opium trade, which helps fund the Taliban insurgency, while on the CIA payroll.
(4) A transformation of the corrupt economy could take up to two decades, and opium production is likely to climb beyond 2013's worrying levels before it falls again, said Jean-Luc Lemahieu, outgoing head of the UN office on drugs and crime in Afghanistan .
(5) Athletic elitism, the glorification of the human body, has succeeded religion as Marx's opium of the people.
(6) Cannabis and opium use has been in Nepal for centuries and in the past they did not pose much of a problem.
(7) In Henley, he encountered with interest the bookshop-owning lesbians who had taken opium with Cocteau, and a prim, elderly lady who had, in her youth, urinated regularly upon pioneering sexologist Havelock Ellis.
(8) But the ACMD research clearly found that the majority of people were not “parked” on opium substitution treatment for long periods of time, with only 10-15% receiving treatment for more than five years.
(9) With lots of water and fertile land, Sangin is perfect for growing the poppies currently being harvested for their opium sap.
(10) Subjects with a positive family history of opium use had an earlier age of onset than the subjects without a family history of opium use.
(11) Two ethnic groups in Laos were compared: the Hmong (or Meo), a tribal group with access to opium in their homes; and the Lao, a peasant people with more limited access, usually in opium dens.
(12) The time-course of changes in vegetative tests was studied in 47 men suffering from stage II opium dependence.
(13) Fifty-six addicted "world travelers" were studied at a treatment facility for opium addicts in Laos.
(14) Cash crops have diversified and replaced the former opium fields; the economy is moving away from a subsistence and cash economy to a mostly cash economy.
(15) They may well also be driving the Taliban effort in Helmand, since control of the opium-rich province would hand a major political advantage to whichever leader achieved it.
(16) Naltrexone blocked opioid-induced euphoria and decreased the craving for opium, but it did not inhibit drug usage.
(17) These studies contribute to the evidence that different cytochrome P-450-dependent mono-oxygenase systems are involved in the O- and N-dealkylation of opium alkaloids.
(18) Opium poppy latex contains a group of laticifer-specific, low-molecular-weight polypeptides called major latex proteins (MLPs).
(19) Communities raising opium poppy as a cash crop had highest crude rates of addiction (7.0-9.8 addicts per 100 people).
(20) The British prosecuted two opium wars in the cause of freedom to export and sell the produce of the East India Company's Bengal factories.