(n.) An oxidation product of uric acid. It is of a pale reddish color, readily soluble in water or alcohol.
Example Sentences:
(1) These and other results suggest that the experimental agents do not provide protection against alloxan inhibition by preventing the entry of alloxan into the intracellular space of the islet.
(2) From the present results it is concluded that secretion of extrapancreatic glucagon increased in response to arginine infusion in the diabetic state, both alloxan diabetic dogs and one-week post-pancreatectomized dogs.
(3) Exposure to alloxan completely abolished insulin response to 20 mM arginine, 1.6 mM glucose, and 11.1 mM glucose.
(4) The enhancement of long-chain fatty acid oxidation and ketogenesis in the perfused rat liver, whether induced acutely by treatment of fed animals with anti-insulin serum or glucagon, or over the longer term by starvation or the induction of alloxan diabetes, was found to ba accompanied by a proportional elevation in the tissue carnitine content.
(5) However, after the single injection of streptozotocin and alloxan, islet cell tumors developed in 42 and 11% of surviving rats, respectively.
(6) The islets, 3 000 to 5 000, were transplanted to alloxan diabetic recipients, in a territory, preferentially with portal-hepatic drainage (mesentery and spleen).
(7) The phenomenon is suggested to be brought about by a modulator substance circulating in the blood of alloxan diabetic and glucocorticoid-treated rats.
(8) When estron was administered to castrated rats with alloxan diabetes the mass of the uterus and the vagina and the height of the uterine endometrium, and of the epithelial layer of the vagina increased to the same degree as in rats with the intact pancreas; reactivity of diabetic rats to estrogen approached the sensitivity of animals with normal pancreatic functions.
(9) Volume densities of islet B cells (= volume density of islet cells immunostained for insulin per islet volume density) decreased and pyknotic nuclei appeared in the islets during the initial 48 hr after alloxan treatment.
(10) The results of this study suggest that the cat is resistant to the diabetogenic effect of alloxan, but is susceptible to its toxic side effects.
(11) Glutamine synthetase and gamma-glutamyltransferase activities of brain and liver homogenates of rats suffering from alloxan diabetes were determined in the soluble fraction (fraction 1) and in that obtained after treatment with 0.2 percent deoxycholate (fraction 2).
(12) Properties of insulin receptors were studied in rat fatty tissue and in plasmatic membranes of liver cells under conditions of alloxan diabetes (within 3 days) and in fasting (within 2 days) as well as under conditions of simultaneous effect of these factors.
(13) Alloxan diabetes and injections of hydrocortisone into intact animals for 5-7 days resulted in a sharp decrease of NADP-dependent malate dehydrogenase in rat epididymal adipose tissue.
(14) Conversely, in STZ-diabetic rats the stimulatory effect of alloxan was reduced to 22% of that elicited in nondiabetic rats.
(15) Oxidation of mitochondrial pyridine nucleotides by alloxan is not mediated by glutathione peroxidase and glutathione reductase and may occur largely nonenzymatically.
(16) Sorbitol metabolism of the endothelial cells of the aorta has been studied in normal and alloxan diabetic rats by the aid of a new time- and gradient governed elution method.
(17) A histochemical evaluation of the activity of chosen oxido-reductive enzymes of the cardiac muscle connected with the citric acid cycle, glycolysis and pentose shunt in the early experimental alloxan diabetes period in white rats has been carried out.
(18) Experimental diabetes, whether induced by alloxan or streptozotocin, decreased the incorporation of [U-14C]glucose into neutral lipids and phospholipids of both the surfactant fraction and the residual fraction of the lung by 60-80%.
(19) Insulin (and glucose) appeared to be specific in correcting the metabolic abnormalities found in the brains of animals with alloxan-induced diabetes.
(20) In the alloxan-diabetic animals no myocardial oedema developed and therefore no further increase of the originally elevated left ventricular diastolic stiffness could be observed.
Pancreatic
Definition:
(a.) Of or pertaining to the pancreas; as, the pancreatic secretion, digestion, ferments.
Example Sentences:
(1) Theophylline kinetics, as an in vivo probe for the potentially toxic cytochrome P-450I pathway of drug metabolism, were studied in 11 healthy volunteers and 11 patients with calcific chronic pancreatitis at Madras, South India.
(2) Histological studies showed that the resulting pancreatitis was usually mild to moderate, being severe only in association with sepsis.
(3) A 61-year-old man experienced four bouts of pancreatitis in 1 year.
(4) We have investigated a physiological role of endogenous insulin on exocrine pancreatic secretion stimulated by a liquid meal as well as exogenous secretin and cholecystokinin octapeptide (CCK-8) in conscious rats.
(5) Other approaches to the diagnosis of pancreatic pseudocysts are reviewed.
(6) The pancreatic changes are unlikely to be an artefact, but rather a direct toxic effect of the alcohol as confirmed by the biochemical changes.
(7) High mortality, severe destruction of pancreatic B-cells and presence of sporadic mononuclear infiltrations in islets and around excretory ducts were observed.
(8) In the present study, 125 oesophageal biopsies obtained under direct vision at endoscopy from 22 patients with Barrett's oesophagus were systematically studied using fluorescence and peroxidase antiperoxidase single and double-staining immunocytochemical methods employing highly specific antibodies to localize the following peptide-containing cell types in Barrett's mucosa: gastrin, somatostatin, gastric inhibitory polypeptide, motilin, neurotensin and pancreatic glucagon.
(9) No methionine-enkephalin-positive nerves could be detected in the common bile duct, pancreatic duct or gallbladder.
(10) As total pancreatectomy markedly reduces the pancreatic hormone level, leading to a mortal hypoglycaemia, we attempted to maintain plasma glucose within the normal range by constant I.V.
(11) In case of biliary and pancreatic duct obstruction with pure pancreatic reflux, both oedema and inflammatory infiltrations were evident, whereas, in the presence of biliary reflux too, more serious histological features were detected.
(12) The computer tomographic appearances of lesions of parenchymatous organs following blunt abdominal trauma are described in 13 patients (five liver, four renal, two splenic and two pancreatic injuries).
(13) These studies establish this preparation as a reproducible model for the direct examination of autonomic influences on endocrine pancreatic function.
(14) Particular attention has been paid to diabetes mellitus and chronic pancreatitis, but a firm conclusion cannot be drawn.
(15) The use of a major pancreatic resection for the surgical management of necrotizing pancreatitis should be excluded from treatment protocols.
(16) Preoperatively, the pancreatic glucagon response was suppressed, while the insulin response was comparable to that in normal control subjects.
(17) Most of the progressive cases were alcoholic, and some showed progression to advanced pancreatitis within 4 years.
(18) The study confirms that secretin influences pancreatic protein secretion and indicates in addition, that pharmacologic doses of the hormone, have the capacity to block acinar cell zymogen granule release.
(19) A study was conducted to assess the suppression of segmental pancreatic allograft rejection by cyclosporine (CSA) alone in baboons and dogs, and subtotal marrow irradiation (TL1) alone and TL 1 in combination with CSA in baboons.
(20) In 2 patients (25%), the preoperative diagnosis of pseudocyst associated with chronic pancreatitis was made.