(v. t.) To make otherwise; to change in some respect, either partially or wholly; to vary; to modify.
(v. t.) To agitate; to affect mentally.
(v. t.) To geld.
(v. i.) To become, in some respects, different; to vary; to change; as, the weather alters almost daily; rocks or minerals alter by exposure.
Example Sentences:
(1) Herpesviruses such as EBV, HSV, and human herpes virus-6 (HHV-6) have a marked tropism for cells of the immune system and therefore infection by these viruses may result in alterations of immune functions, leading at times to a state of immunosuppression.
(2) The process of sequence rearrangement appears to be a significant part of the evolution of the genome and may have a much greater effect on the evolution of the phenotype than sequence alteration by base substitution.
(3) The various evocational changes appear to form sets of interconnected systems and this complex network seems to embody some plasticity since it has been possible to suppress experimentally some of the most universal evocational events or alter their temporal order without impairing evocation itself.
(4) When chimeric animals were subjected to a lethal challenge of endotoxin, their response was markedly altered by the transferred lymphoid cells.
(5) Morphological alterations in the lungs of pheasants after prolonged high-dosage administration of bleomycin sulfate were studied by light and electron microscopy.
(6) Incubation with IFN alpha or IFN gamma for 24 h resulted in only modest cytokinetic alterations, and they did not modify the effects of FUra.
(7) We report a series of experiments designed to determine if agents and conditions that have been reported to alter sodium reabsorption, Na-K-ATPase activity or cellular structure in the rat distal nephron might also regulate the density or affinity of binding of 3H-metolazone to the putative thiazide receptor in the distal nephron.
(8) In dorsoventral (DV) reversed wings at both shoulder or flank level, the motor axons do not alter their course as they enter the graft.
(9) Neither spermidine nor spermine (0.5 mM) significantly altered [Ca2+]i.
(10) In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
(11) When the concentration of thrombin or fibrinogen was altered systematically, mu T and mup were found to mirror each other except when the fibrinogen concentration was increased at low thrombin concentrations.
(12) Arteries treated with atrial natriuretic peptide showed no alterations in relaxation or cGMP content after incubation with pertussis toxin.
(13) These results could be explained by altered tissue blood flow and a decreased metabolic capacity of the liver in obese subjects.
(14) The sequential histopathologic alterations in femorotibial joints of partial meniscectomized male and female guinea pigs were evaluated at 1, 2, 3, 6, and 12 weeks post-surgery.
(15) However, survival was closely related to the severity of the illness at the time of randomization and was not altered by shunting.
(16) Brain damage may be followed by a number of dynamic events including reactive synaptogenesis, rerouting of axons to unusual locations and altered axon retraction processes.
(17) Since the advance and return of sperm inside the tubes could facilitate the interaction of sperm with secretions participating in its maturation, the persistent infertility after vasectomy could be related to the contractile alteration that follows the excessive tubal distention.
(18) Sixteen patients (27%) manifested anomalies of the urinary tract: 12 had markedly altered kidneys, 8 of which were unilateral and ipsilateral to the diaphragmatic defect.
(19) Corticosterone (4 x 10(-5) M) did not alter the stimulation-evoked 3H-overflow at 1-30 Hz.
(20) The results show that the presence of histones does not alter the bimodal DNA binding process.
Duffer
Definition:
(n.) A peddler or hawker, especially of cheap, flashy articles, as sham jewelry; hence, a sham or cheat.
(n.) A stupid, awkward, inefficient person.
Example Sentences:
(1) They’re throwing everything they’ve got at this and, while there are bound to be a few duffers in the mix, you can bet that your mum will end up loving at least one of them.
(2) The West End debut of Keira Knightley will irresistibly get all the headlines and shift a lot of the tickets, though the rest of the cast of The Misanthrope – including Damian Lewis, Dominic Rowan and Tara Fitzgerald – are not exactly duffers.
(3) For the first time in years, the BBC has taken the contest seriously, stung by criticism from viewers and the rest of the continent that despite the UK's musical heritage it ends up entering duffers.
(4) Asked if the children may go on an adventurous sailing-and-camping expedition, the absent father replies, heartlessly: "Better drowned than duffers if not duffers will not drown."
(5) When the New York Times reporter Don Van Natta Jr played with Clinton in 2000, the duffer-in-chief simply replayed any of his stray shots, leading Van Natta to conclude that "[Clinton] followed the rules .
(6) Hardly anybody eats the stuff beyond a few old duffers nostalgic for the bad old days when protein was scarce, and a few ridiculous rump-imperialist uyoku.
(7) As a joke doing the rounds in Delhi put it, the three national-party candidates were a Duffer, a Bluffer and a Muffler.
(8) My hunch is that the old, badly informed duffers at the top of the BBC who took this perverse decision have yet to actually sit through Sun, Sex & Suspicious Parents .
(9) What says "This is my world now, you past-it old duffer" more than being tossed your child's defunct smartphone?
(10) Precocious rapid sleep duffers from usual one in an inclusion into the dream content the experimental situations and their emotional saturation.
(11) Firebrand lawyer and human rights campaigner Asma Jahangir caused a sensation by delivering a television tongue-lashing against "duffer" generals who, she said, were more interested in running wedding halls than defending their territory.
(12) The duffer was Rahul Gandhi; the muffler referred to third-party leader Arvind Kejriwal's habit of wrapping himself in a scarf.
(13) Katie Allen (@KatieAllenGdn) Carney on review post forex rigging stories: we can't come out of this with a shadow of doubt about the integrity of the Bank of England March 11, 2014 George Mudie MP, though, isn’t impressed -- accusing Carney of acting like his predecessor Sir Mervyn King by passing the buck onto other people; either the ‘old duffers’ on the Bank’s Court, or to FCA boss Martin Wheatley.
(14) It's good of you to put on a much more lavish show for us than you did for that old duffer, Gordo.
(15) Louis van Gaal is a duffer all over again after supervising three defeats in a row – the light aeroplane on duty at Anfield might soon be back here at this rate – while Tony Pulis is a genius once more for all but securing safety for his side at the most intimidating of venues.