(v. t.) To make otherwise; to change in some respect, either partially or wholly; to vary; to modify.
(v. t.) To agitate; to affect mentally.
(v. t.) To geld.
(v. i.) To become, in some respects, different; to vary; to change; as, the weather alters almost daily; rocks or minerals alter by exposure.
Example Sentences:
(1) Herpesviruses such as EBV, HSV, and human herpes virus-6 (HHV-6) have a marked tropism for cells of the immune system and therefore infection by these viruses may result in alterations of immune functions, leading at times to a state of immunosuppression.
(2) The process of sequence rearrangement appears to be a significant part of the evolution of the genome and may have a much greater effect on the evolution of the phenotype than sequence alteration by base substitution.
(3) The various evocational changes appear to form sets of interconnected systems and this complex network seems to embody some plasticity since it has been possible to suppress experimentally some of the most universal evocational events or alter their temporal order without impairing evocation itself.
(4) When chimeric animals were subjected to a lethal challenge of endotoxin, their response was markedly altered by the transferred lymphoid cells.
(5) Morphological alterations in the lungs of pheasants after prolonged high-dosage administration of bleomycin sulfate were studied by light and electron microscopy.
(6) Incubation with IFN alpha or IFN gamma for 24 h resulted in only modest cytokinetic alterations, and they did not modify the effects of FUra.
(7) We report a series of experiments designed to determine if agents and conditions that have been reported to alter sodium reabsorption, Na-K-ATPase activity or cellular structure in the rat distal nephron might also regulate the density or affinity of binding of 3H-metolazone to the putative thiazide receptor in the distal nephron.
(8) In dorsoventral (DV) reversed wings at both shoulder or flank level, the motor axons do not alter their course as they enter the graft.
(9) Neither spermidine nor spermine (0.5 mM) significantly altered [Ca2+]i.
(10) In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
(11) When the concentration of thrombin or fibrinogen was altered systematically, mu T and mup were found to mirror each other except when the fibrinogen concentration was increased at low thrombin concentrations.
(12) Arteries treated with atrial natriuretic peptide showed no alterations in relaxation or cGMP content after incubation with pertussis toxin.
(13) These results could be explained by altered tissue blood flow and a decreased metabolic capacity of the liver in obese subjects.
(14) The sequential histopathologic alterations in femorotibial joints of partial meniscectomized male and female guinea pigs were evaluated at 1, 2, 3, 6, and 12 weeks post-surgery.
(15) However, survival was closely related to the severity of the illness at the time of randomization and was not altered by shunting.
(16) Brain damage may be followed by a number of dynamic events including reactive synaptogenesis, rerouting of axons to unusual locations and altered axon retraction processes.
(17) Since the advance and return of sperm inside the tubes could facilitate the interaction of sperm with secretions participating in its maturation, the persistent infertility after vasectomy could be related to the contractile alteration that follows the excessive tubal distention.
(18) Sixteen patients (27%) manifested anomalies of the urinary tract: 12 had markedly altered kidneys, 8 of which were unilateral and ipsilateral to the diaphragmatic defect.
(19) Corticosterone (4 x 10(-5) M) did not alter the stimulation-evoked 3H-overflow at 1-30 Hz.
(20) The results show that the presence of histones does not alter the bimodal DNA binding process.
Irrevocable
Definition:
(a.) Incapable of being recalled or revoked; unchangeable; irreversible; unalterable; as, an irrevocable promise or decree; irrevocable fate.
Example Sentences:
(1) Continuing corporate concerns over the costs of health care, and recent changes in federal policies regarding Medicare and the taxation of employee benefit funds, threaten to alter the system of postretirement health benefits substantially and perhaps irrevocably for many.
(2) It took the first intifada (the largely unarmed, six-year uprising that preceded the current, far more violent one) to transform Yassin wholly and irrevocably, and to pitchfork him into the forefront of the Palestinian struggle as a serious rival to Arafat himself.
(3) The council had been politically unstable and divided, and although parents were voting with their feet – less than half were choosing to send their children to the borough's secondary schools – there was a widespread feeling that nothing could be done, that the borough's failings were irrevocable.
(4) Tsipras also emphasised that Greece is a “sovereign country with an irrevocable right to conduct a multi-faceted foreign policy”.
(5) Monocytic differentiation was reversible upon removal of CSF-1, implying that CSF-1 was required for maintenance of the monocyte phenotype but was not sufficient to induce an irrevocable commitment to differentiation.
(6) Fertility in women 40 years of age or older is decreased, and in those with ovarian failure it is thought to be irrevocably lost.
(7) Still, there's an upside to 007's monogamy, and it may just explain how this much-maligned film has wheedled its way so irrevocably into my affections: uniquely in the world of Bond, it allows a vein of romantic adventure to develop that's real, not illusory.
(8) The reason for King's change of view is simple: he believes the world changed irrevocably on 15 September last year when the collapse of Lehman Brothers set off a month of financial turmoil that plunged the global economy into a deep slump.
(9) In the first experiment, 14-day prenatal lung explants (14 + 0 days) containing macrophage precursors but not matured cells were exposed to individual CSFs for 7 days in an attempt to determine whether precursors are committed irrevocably to the macrophage line or can be altered by exposure to factors promoting significant granulocyte development.
(10) The team’s failure led to the immediate and “irrevocable” resignations of both the manager and the president of the Italian federation, Giancarlo Abete.
(11) Above all, he must face the increasing suggestion that his party is irrevocably on course to do significantly worse with him as its leader in the 2015 general election than it would do under someone new, specifically the business secretary Vince Cable .
(12) Lord Mandelson, the former Labour business secretary, has also said he is no longer a supporter and that Labour should "think twice before binding themselves irrevocably" to the project Patrick McLoughlin, the transport secretary, rejected Darling's claim that going ahead with HS2 could have "catastrophic" consequences for spending on other transport infrastructure.
(13) In a sworn affidavit accompanying the motion, Dershowitz states that Roberts’s lawyers “levelled totally false and outrageous charges against me that have been damaged around the world and threaten to damage my reputation irrevocably”.
(14) Without the presence and participation of those Jews, Europe irrevocably lost a crucial and invaluable element of its identity.
(15) "We, the people of the Azawad [desert region] proclaim the irrevocable independence of the state of the Azawad starting from this day, Friday 6 April 2012," the statement read.
(16) The irrevocable breakdown of leucine was estimated from the 3H-labelling of body water.
(17) Particularly grave in its consequences is the gastric stump carcinoma with its fateful and irrevocable course for patients with B II gastrectomy if regular gastroscopic and laboratory follow-up inspection do not take place (regardless of questionable operation indication).
(18) Do your own due diligence before making irrevocable choices.
(19) Michael Jacobs, senior adviser for the New Climate Economy project, says the long-term goals in the agreement send investors the clearest sign “that the world was on an irreversible and irrevocable downward trend in emissions”.
(20) But there are deep nerves in Whitehall that George Osborne is reaching the stage where voters will make an irrevocable judgment that he has failed to deliver his two key economic pledges made during the 2010 election.