(v. t.) To make otherwise; to change in some respect, either partially or wholly; to vary; to modify.
(v. t.) To agitate; to affect mentally.
(v. t.) To geld.
(v. i.) To become, in some respects, different; to vary; to change; as, the weather alters almost daily; rocks or minerals alter by exposure.
Example Sentences:
(1) Herpesviruses such as EBV, HSV, and human herpes virus-6 (HHV-6) have a marked tropism for cells of the immune system and therefore infection by these viruses may result in alterations of immune functions, leading at times to a state of immunosuppression.
(2) The process of sequence rearrangement appears to be a significant part of the evolution of the genome and may have a much greater effect on the evolution of the phenotype than sequence alteration by base substitution.
(3) The various evocational changes appear to form sets of interconnected systems and this complex network seems to embody some plasticity since it has been possible to suppress experimentally some of the most universal evocational events or alter their temporal order without impairing evocation itself.
(4) When chimeric animals were subjected to a lethal challenge of endotoxin, their response was markedly altered by the transferred lymphoid cells.
(5) Morphological alterations in the lungs of pheasants after prolonged high-dosage administration of bleomycin sulfate were studied by light and electron microscopy.
(6) Incubation with IFN alpha or IFN gamma for 24 h resulted in only modest cytokinetic alterations, and they did not modify the effects of FUra.
(7) We report a series of experiments designed to determine if agents and conditions that have been reported to alter sodium reabsorption, Na-K-ATPase activity or cellular structure in the rat distal nephron might also regulate the density or affinity of binding of 3H-metolazone to the putative thiazide receptor in the distal nephron.
(8) In dorsoventral (DV) reversed wings at both shoulder or flank level, the motor axons do not alter their course as they enter the graft.
(9) Neither spermidine nor spermine (0.5 mM) significantly altered [Ca2+]i.
(10) In addition to the changes associated with blood group A, we also found a decrease in sugar content, alterations in other antigens, and changes in the levels of several glycosyltransferases in cancerous tissues.
(11) When the concentration of thrombin or fibrinogen was altered systematically, mu T and mup were found to mirror each other except when the fibrinogen concentration was increased at low thrombin concentrations.
(12) Arteries treated with atrial natriuretic peptide showed no alterations in relaxation or cGMP content after incubation with pertussis toxin.
(13) These results could be explained by altered tissue blood flow and a decreased metabolic capacity of the liver in obese subjects.
(14) The sequential histopathologic alterations in femorotibial joints of partial meniscectomized male and female guinea pigs were evaluated at 1, 2, 3, 6, and 12 weeks post-surgery.
(15) However, survival was closely related to the severity of the illness at the time of randomization and was not altered by shunting.
(16) Brain damage may be followed by a number of dynamic events including reactive synaptogenesis, rerouting of axons to unusual locations and altered axon retraction processes.
(17) Since the advance and return of sperm inside the tubes could facilitate the interaction of sperm with secretions participating in its maturation, the persistent infertility after vasectomy could be related to the contractile alteration that follows the excessive tubal distention.
(18) Sixteen patients (27%) manifested anomalies of the urinary tract: 12 had markedly altered kidneys, 8 of which were unilateral and ipsilateral to the diaphragmatic defect.
(19) Corticosterone (4 x 10(-5) M) did not alter the stimulation-evoked 3H-overflow at 1-30 Hz.
(20) The results show that the presence of histones does not alter the bimodal DNA binding process.
Modulation
Definition:
(n.) The act of modulating, or the state of being modulated; as, the modulation of the voice.
(n.) Sound modulated; melody.
(n.) A change of key, whether transient, or until the music becomes established in the new key; a shifting of the tonality of a piece, so that the harmonies all center upon a new keynote or tonic; the art of transition out of the original key into one nearly related, and so on, it may be, by successive changes, into a key quite remote. There are also sudden and unprepared modulations.
Example Sentences:
(1) The variation in thickness of the LLFL may modulate the species causing damage to the cells below it.
(2) These included bringing in the A* grade, reducing the number of modules from six to four, and a greater attempt to assess the whole course at the end.
(3) The vascular endothelium is capable of regulating tissue perfusion by the release of endothelium-derived relaxing factor to modulate vasomotor tone of the resistance vasculature.
(4) Quantitative determinations indicate that the amount of PBG-D mRNA is modulated both by the erythroid nature of the tissue and by cell proliferation, probably at the transcriptional level.
(5) Gel filtration of the 40,000 rpm supernatant fraction of a homogenate of rat cerebral cortex on a Sepharose 6B column yielded two fractions: fraction II with the "Ca(2+) plus Mg(2+)-dependent" phosphodiesterase activity and fraction III containing its modulator.
(6) This modulation results from repetitive, alternating bursts of excitatory and inhibitory postsynaptic potentials, which are caused at least in part by synaptic feedback to the command neurons from identified classes of neurons in the feeding network.
(7) Modulation of the voltage-gated K+ conductance in T-lymphocytes by substance P was examined.
(8) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(9) This study examines the role of sex hormones in modulating the expression of autoimmunity in NZB x NZW F1 mice.
(10) More needs to be known about the direct and indirect modulation of cytokine production by cyclosporin A in connective tissues, in order to understand its potential value in clinical disorders.
(11) We suggest that neuronal PACAP may serve to modulate motor activity and secretion in the lower esophageal sphincter region.
(12) Furthermore, modulation of the assay by prostaglandin E2 (PGE2) was used to increase its sensitivity.
(13) Masking experiments are demonstrated for electrical frequency-modulated tone bursts from 1,000 to 10,000 cps and from 10,000 to 1,000 cps with superimposed clicks.
(14) From these results, BM-Eo are naive and seem to be a good indicator for eosinophilotaxis and its modulation.
(15) Administration of modulators in combinations of threes resulted in still further reduction of tumor incidences to 22.2% (SS + MC + AA), 19.2% (SS + MC + RA), 16% (MC + AA + RA) and 23.1% (AA + RA + SS).
(16) These findings suggest that activation of protein kinase C may act as a feedback inhibitor to modulate ligand-mediated increases in [Ca2+]i.
(17) These studies demonstrate that vWF interaction with GP Ib may be modulated by botrocetin binding to a discontinuous site located within residues 539-643.
(18) This contrasts sharply with the reduction in both the frequency and surface area of sensory neuron active zones that accompanies long-term habituation, and suggests that modulation of active zone number and size may be an anatomical correlate that lies in the long-term domain.
(19) Thus, it appears that the modulation of the phosphorylation of these cytosolic proteins represents an essential step in the regulation of T lymphocyte activation.
(20) Energy conformational calculations on these compounds were also carried out using the empirical energy program called MOLMEC, in order to better understand how the 4-R substituents modulate receptor binding affinities and efficacies.